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- DNA_gyrase abstract "DNA gyrase, also known as topoisomerase II or simply as gyrase, is an enzyme that relieves strain while double-stranded DNA is being unwound by helicase. This causes negative supercoiling of the DNA. The gyrase supercoils (or relaxes positive supercoils) into DNA by looping the template so as to form a crossing, then cutting one of the double helices and passing the other through it before releasing the break, changing the linking number by two in each enzymatic step. This process occurs in prokaryotes (in particular, in bacteria), whose single circular DNA is cut by DNA gyrase and the two ends are then twisted around each other to form supercoils. Gyrase has been found in the apicoplast of the malarial parasite Plasmodium falciparum, a unicellular eukaryote. Bacterial DNA gyrase is the target of many antibiotics, including nalidixic acid, novobiocin, and ciprofloxacin.The unique ability of gyrase to introduce negative supercoils into DNA is what allows bacterial DNA to have free negative supercoils. The ability of gyrase to relax positive supercoils comes into play during DNA replication and prokaryotic transcription. The right-handed nature of the DNA double helix causes positive supercoils to accumulate ahead of a translocating enzyme, in the case of DNA replication, a DNA polymerase. The ability of gyrase (and topoisomerase IV) to relax positive supercoils allows superhelical tension ahead of the polymerase to be released so that replication can continue.".
- DNA_gyrase ecNumber "5.99.1.3".
- DNA_gyrase wikiPageID "988524".
- DNA_gyrase wikiPageLength "6955".
- DNA_gyrase wikiPageOutDegree "28".
- DNA_gyrase wikiPageRevisionID "703823277".
- DNA_gyrase wikiPageWikiLink Adenosine_triphosphate.
- DNA_gyrase wikiPageWikiLink Aminocoumarin.
- DNA_gyrase wikiPageWikiLink Antibiotics.
- DNA_gyrase wikiPageWikiLink Apicoplast.
- DNA_gyrase wikiPageWikiLink Bacteria.
- DNA_gyrase wikiPageWikiLink Category:DNA.
- DNA_gyrase wikiPageWikiLink Category:EC_5.99.1.
- DNA_gyrase wikiPageWikiLink Ciprofloxacin.
- DNA_gyrase wikiPageWikiLink Competitive_inhibition.
- DNA_gyrase wikiPageWikiLink DNA.
- DNA_gyrase wikiPageWikiLink DNA_polymerase.
- DNA_gyrase wikiPageWikiLink DNA_replication.
- DNA_gyrase wikiPageWikiLink DNA_supercoil.
- DNA_gyrase wikiPageWikiLink Enzyme.
- DNA_gyrase wikiPageWikiLink Helicase.
- DNA_gyrase wikiPageWikiLink Linking_number.
- DNA_gyrase wikiPageWikiLink Nalidixic_acid.
- DNA_gyrase wikiPageWikiLink Novobiocin.
- DNA_gyrase wikiPageWikiLink Nucleic_acid_double_helix.
- DNA_gyrase wikiPageWikiLink Plasmodium_falciparum.
- DNA_gyrase wikiPageWikiLink Prokaryote.
- DNA_gyrase wikiPageWikiLink Quinolone.
- DNA_gyrase wikiPageWikiLink Topoisomerase_IV.
- DNA_gyrase wikiPageWikiLink Transcription_(genetics).
- DNA_gyrase wikiPageWikiLink Wikt:decatenation.
- DNA_gyrase wikiPageWikiLinkText "'''G'''yrase".
- DNA_gyrase wikiPageWikiLinkText "''gyr''B".
- DNA_gyrase wikiPageWikiLinkText "DNA gyrase".
- DNA_gyrase wikiPageWikiLinkText "dna gyrase".
- DNA_gyrase ecNumber "5.99".
- DNA_gyrase name "DNA gyrase".
- DNA_gyrase wikiPageUsesTemplate Template:DNA_replication.
- DNA_gyrase wikiPageUsesTemplate Template:Enzymes.
- DNA_gyrase wikiPageUsesTemplate Template:Infobox_enzyme.
- DNA_gyrase wikiPageUsesTemplate Template:Portal_bar.
- DNA_gyrase wikiPageUsesTemplate Template:Reflist.
- DNA_gyrase wikiPageUsesTemplate Template:Topoisomerases.
- DNA_gyrase subject Category:DNA.
- DNA_gyrase subject Category:EC_5.99.1.
- DNA_gyrase hypernym Enzyme.
- DNA_gyrase type Biomolecule.
- DNA_gyrase type Enzyme.
- DNA_gyrase type Protein.
- DNA_gyrase type Redirect.
- DNA_gyrase type Thing.
- DNA_gyrase type Q206229.
- DNA_gyrase type Q8047.
- DNA_gyrase comment "DNA gyrase, also known as topoisomerase II or simply as gyrase, is an enzyme that relieves strain while double-stranded DNA is being unwound by helicase. This causes negative supercoiling of the DNA. The gyrase supercoils (or relaxes positive supercoils) into DNA by looping the template so as to form a crossing, then cutting one of the double helices and passing the other through it before releasing the break, changing the linking number by two in each enzymatic step.".
- DNA_gyrase label "DNA gyrase".
- DNA_gyrase sameAs Q420548.
- DNA_gyrase sameAs Gyrase.
- DNA_gyrase sameAs ADN_girasa.
- DNA_gyrase sameAs ADN_gyrase.
- DNA_gyrase sameAs ADN_xirase.
- DNA_gyrase sameAs DNA_girasi.
- DNA_gyrase sameAs DNAジャイレース.
- DNA_gyrase sameAs Gyraza_DNA.
- DNA_gyrase sameAs m.028cgf3.
- DNA_gyrase sameAs m.0vxf15j.
- DNA_gyrase sameAs ДНК-гираза.
- DNA_gyrase sameAs DNK_giraza.
- DNA_gyrase sameAs DNK_giraza.
- DNA_gyrase sameAs Q420548.
- DNA_gyrase sameAs DNA旋转酶.
- DNA_gyrase wasDerivedFrom DNA_gyrase?oldid=703823277.
- DNA_gyrase isPrimaryTopicOf DNA_gyrase.