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- DNA_condensation abstract "DNA condensation refers to the process of compacting DNA molecules in vitro or in vivo. Mechanistic details of DNA packing are essential for its functioning in the process of gene regulation in living systems. Condensed DNA often has surprising properties, which one would not predict from classical concepts of dilute solutions. Therefore DNA condensation in vitro serves as a model system for many processes of physics, biochemistry and biology. In addition, DNA condensation has many potential applications in medicine and biotechnology.DNA diameter is about 2 nm, while the length of a stretched single molecule may be up to several dozens of centimetres depending on the organism. Many features of the DNA double helix contribute to its large stiffness, including the mechanical properties of the sugar-phosphate backbone, electrostatic repulsion between phosphates (DNA bears on average one elementary negative charge per each 0.17 nm of the double helix), stacking interactions between the bases of each individual strand, and strand-strand interactions. DNA is one of the stiffest natural polymers, yet it is also one of the longest molecules. This means that at large distances DNA can be considered as a flexible rope, and on a short scale as a stiff rod. Like a garden hose, unpacked DNA would randomly occupy a much larger volume than when it is orderly packed. Mathematically, for a non-interacting flexible chain randomly diffusing in 3D, the end-to-end distance would scale as a square root of the polymer length. For real polymers such as DNA, this gives only a very rough estimate; what is important, is that the space available for the DNA in vivo is much smaller than the space that it would occupy in the case of a free diffusion in the solution. In order to cope with the volume constraints, DNA has a striking property to pack itself in the appropriate solution conditions with the help of ions and other molecules. Usually, DNA condensation is defined as \"the collapse of extended DNA chains into compact, orderly particles containing only one or a few molecules\". This definition applies to many situations in vitro and is also close to the definition of DNA condensation in bacteria as \"adoption of relatively concentrated, compact state occupying a fraction of the volume available\". In eukaryotes, the DNA size and the number of other participating players are much larger, and a DNA molecule forms millions of ordered nucleoprotein particles, the nucleosomes, which is just the first of many levels of DNA packing.".
- DNA_condensation wikiPageID "28268694".
- DNA_condensation wikiPageLength "11864".
- DNA_condensation wikiPageOutDegree "61".
- DNA_condensation wikiPageRevisionID "701142830".
- DNA_condensation wikiPageWikiLink Bacteriophage.
- DNA_condensation wikiPageWikiLink Biochemistry.
- DNA_condensation wikiPageWikiLink Biology.
- DNA_condensation wikiPageWikiLink Biotechnology.
- DNA_condensation wikiPageWikiLink Capsid.
- DNA_condensation wikiPageWikiLink Category:Biotechnology.
- DNA_condensation wikiPageWikiLink Category:DNA.
- DNA_condensation wikiPageWikiLink Category:Epigenetics.
- DNA_condensation wikiPageWikiLink Category:Molecular_biology.
- DNA_condensation wikiPageWikiLink Category:Molecular_genetics.
- DNA_condensation wikiPageWikiLink Category:Nuclear_substructures.
- DNA_condensation wikiPageWikiLink Chloroplast.
- DNA_condensation wikiPageWikiLink Cholesteric_liquid_crystal.
- DNA_condensation wikiPageWikiLink Chromatin.
- DNA_condensation wikiPageWikiLink Chromosome.
- DNA_condensation wikiPageWikiLink Counterion_correlation.
- DNA_condensation wikiPageWikiLink DNA.
- DNA_condensation wikiPageWikiLink Dinoflagellate.
- DNA_condensation wikiPageWikiLink Equilibrium_binding.
- DNA_condensation wikiPageWikiLink Euchromatin.
- DNA_condensation wikiPageWikiLink Eukaryote.
- DNA_condensation wikiPageWikiLink Gene.
- DNA_condensation wikiPageWikiLink Heterochromatin.
- DNA_condensation wikiPageWikiLink Hexagon.
- DNA_condensation wikiPageWikiLink Histone.
- DNA_condensation wikiPageWikiLink Histone_H1.
- DNA_condensation wikiPageWikiLink Histone_H2A.
- DNA_condensation wikiPageWikiLink Histone_H2B.
- DNA_condensation wikiPageWikiLink Histone_H3.
- DNA_condensation wikiPageWikiLink Histone_H4.
- DNA_condensation wikiPageWikiLink Hydration_forces.
- DNA_condensation wikiPageWikiLink In_vitro.
- DNA_condensation wikiPageWikiLink In_vivo.
- DNA_condensation wikiPageWikiLink Ion.
- DNA_condensation wikiPageWikiLink Isotropy.
- DNA_condensation wikiPageWikiLink Lipid.
- DNA_condensation wikiPageWikiLink Liposome.
- DNA_condensation wikiPageWikiLink Liquid_crystal.
- DNA_condensation wikiPageWikiLink Medicine.
- DNA_condensation wikiPageWikiLink Membrane.
- DNA_condensation wikiPageWikiLink Metal.
- DNA_condensation wikiPageWikiLink Mitochondrion.
- DNA_condensation wikiPageWikiLink Nucleic_acid_double_helix.
- DNA_condensation wikiPageWikiLink Nucleoprotein.
- DNA_condensation wikiPageWikiLink Nucleosome.
- DNA_condensation wikiPageWikiLink Peptide.
- DNA_condensation wikiPageWikiLink Phase_transition.
- DNA_condensation wikiPageWikiLink Phosphate.
- DNA_condensation wikiPageWikiLink Physics.
- DNA_condensation wikiPageWikiLink Polyamine.
- DNA_condensation wikiPageWikiLink Protamine.
- DNA_condensation wikiPageWikiLink Protein.
- DNA_condensation wikiPageWikiLink Regulation_of_gene_expression.
- DNA_condensation wikiPageWikiLink Scientific_modelling.
- DNA_condensation wikiPageWikiLink Solution.
- DNA_condensation wikiPageWikiLink Virus.
- DNA_condensation wikiPageWikiLink File:Chromatin_chromosome.png.
- DNA_condensation wikiPageWikiLinkText "DNA condensation".
- DNA_condensation wikiPageWikiLinkText "DNA condensing agents".
- DNA_condensation wikiPageWikiLinkText "condensation".
- DNA_condensation wikiPageUsesTemplate Template:Chromo.
- DNA_condensation wikiPageUsesTemplate Template:Citation_needed.
- DNA_condensation wikiPageUsesTemplate Template:Cite_journal.
- DNA_condensation wikiPageUsesTemplate Template:Molecular_Biology.
- DNA_condensation wikiPageUsesTemplate Template:Nucleus.
- DNA_condensation wikiPageUsesTemplate Template:Reflist.
- DNA_condensation subject Category:Biotechnology.
- DNA_condensation subject Category:DNA.
- DNA_condensation subject Category:Epigenetics.
- DNA_condensation subject Category:Molecular_biology.
- DNA_condensation subject Category:Molecular_genetics.
- DNA_condensation subject Category:Nuclear_substructures.
- DNA_condensation type Epigenetic.
- DNA_condensation comment "DNA condensation refers to the process of compacting DNA molecules in vitro or in vivo. Mechanistic details of DNA packing are essential for its functioning in the process of gene regulation in living systems. Condensed DNA often has surprising properties, which one would not predict from classical concepts of dilute solutions. Therefore DNA condensation in vitro serves as a model system for many processes of physics, biochemistry and biology.".
- DNA_condensation label "DNA condensation".
- DNA_condensation sameAs Q3646716.
- DNA_condensation sameAs تكثيف_الحمض_النووي.
- DNA_condensation sameAs Кандэнсацыя_ДНК.
- DNA_condensation sameAs Kondenzace_DNA.
- DNA_condensation sameAs فشردگی_دیانای.
- DNA_condensation sameAs m.0cn_ql7.
- DNA_condensation sameAs Kondenzacija_DNK.
- DNA_condensation sameAs Kondenzacija_DNK.
- DNA_condensation sameAs Q3646716.
- DNA_condensation wasDerivedFrom DNA_condensation?oldid=701142830.
- DNA_condensation isPrimaryTopicOf DNA_condensation.