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- DM_domain abstract "In molecular biology the DM domain is a protein domain first discovered in the doublesex proteins of Drosophila melanogaster and is also seen in proteins from Caenorhabditis elegans. In D. melanogaster the doublesex gene controls somatic sexual differentiation by producing alternatively spliced mRNAs encoding related sex-specific polypeptides. These proteins are believed to function as transcription factors on downstream sex-determination genes, especially on neuroblast differentiation and yolk protein genes transcription. The DM domain binds DNA as a dimer, allowing the recognition of pseudopalindromic sequences . The NMR analysis of the DSX DM domain revealed a novel zinc module containing 'intertwined' CCHC and HCCC zinc-binding sites. The recognition of the DNA requires the carboxy-terminal basic tail which contacts the minor groove of the target sequence.".
- DM_domain symbol "DM".
- DM_domain thumbnail PDB_1lpv_EBI.jpg?width=300.
- DM_domain wikiPageID "31890027".
- DM_domain wikiPageLength "3838".
- DM_domain wikiPageOutDegree "21".
- DM_domain wikiPageRevisionID "591035127".
- DM_domain wikiPageWikiLink Alternative_splicing.
- DM_domain wikiPageWikiLink Category:Protein_domains.
- DM_domain wikiPageWikiLink Category:Protein_families.
- DM_domain wikiPageWikiLink Cellular_differentiation.
- DM_domain wikiPageWikiLink Domain_(biology).
- DM_domain wikiPageWikiLink Doublesex.
- DM_domain wikiPageWikiLink Drosophila_melanogaster.
- DM_domain wikiPageWikiLink Gene.
- DM_domain wikiPageWikiLink Molecular_binding.
- DM_domain wikiPageWikiLink Nucleic_acid_double_helix.
- DM_domain wikiPageWikiLink Peptide.
- DM_domain wikiPageWikiLink Protein.
- DM_domain wikiPageWikiLink Sequence.
- DM_domain wikiPageWikiLink Sequence_(biology).
- DM_domain wikiPageWikiLink Transcription_(genetics).
- DM_domain wikiPageWikiLink Upstream_and_downstream_(DNA).
- DM_domain wikiPageWikiLink Zinc.
- DM_domain wikiPageWikiLinkText "DM domain".
- DM_domain caption "drosophila melanogaster doublesex , nmr, 18 structures".
- DM_domain interpro "IPR001275".
- DM_domain name "DM domain".
- DM_domain pfam "PF00751".
- DM_domain scop "1".
- DM_domain smart "SM00718".
- DM_domain symbol "DM".
- DM_domain wikiPageUsesTemplate Template:Infobox_protein_family.
- DM_domain wikiPageUsesTemplate Template:InterPro_content.
- DM_domain wikiPageUsesTemplate Template:Reflist.
- DM_domain subject Category:Protein_domains.
- DM_domain subject Category:Protein_families.
- DM_domain hypernym Domain.
- DM_domain type Biomolecule.
- DM_domain type Protein.
- DM_domain type Chemical.
- DM_domain type Domain.
- DM_domain type Thing.
- DM_domain type Q206229.
- DM_domain type Q8054.
- DM_domain comment "In molecular biology the DM domain is a protein domain first discovered in the doublesex proteins of Drosophila melanogaster and is also seen in proteins from Caenorhabditis elegans. In D. melanogaster the doublesex gene controls somatic sexual differentiation by producing alternatively spliced mRNAs encoding related sex-specific polypeptides.".
- DM_domain label "DM domain".
- DM_domain sameAs Q5205666.
- DM_domain sameAs m.0gvsmk2.
- DM_domain sameAs Q5205666.
- DM_domain wasDerivedFrom DM_domain?oldid=591035127.
- DM_domain depiction PDB_1lpv_EBI.jpg.
- DM_domain isPrimaryTopicOf DM_domain.