Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/DFFA> ?p ?o }
Showing triples 1 to 66 of
66
with 100 triples per page.
- DFFA abstract "DNA fragmentation factor subunit alpha (DFFA), also known as Inhibitor of caspase-activated DNase (ICAD), is a protein that in humans is encoded by the DFFA gene.Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.The C-terminal domain of DFFA (DFF-C) consists of four alpha-helices, which are folded in a helix-packing arrangement, with alpha-2 and alpha-3 packing against a long C-terminal helix (alpha-4). The main function of this domain is the inhibition of DFFB by binding to its C-terminal catalytic domain through ionic interactions, thereby inhibiting the fragmentation of DNA in the apoptotic process. In addition to blocking the DNase activity of DFFB, the C-terminal region of DFFA is also important for the DFFB-specific folding chaperone activity, as demonstrated by the ability of DFFA to refold DFFB.".
- DFFA entrezgene "1676".
- DFFA symbol "DFF-C".
- DFFA thumbnail PDB_1koy_EBI.jpg?width=300.
- DFFA wikiPageID "14754828".
- DFFA wikiPageLength "11423".
- DFFA wikiPageOutDegree "16".
- DFFA wikiPageRevisionID "678271118".
- DFFA wikiPageWikiLink Alpha_helix.
- DFFA wikiPageWikiLink Apoptosis.
- DFFA wikiPageWikiLink C-terminus.
- DFFA wikiPageWikiLink Catalysis.
- DFFA wikiPageWikiLink Category:Protein_domains.
- DFFA wikiPageWikiLink Chaperone_(protein).
- DFFA wikiPageWikiLink DFFB.
- DFFA wikiPageWikiLink DNA.
- DFFA wikiPageWikiLink Deoxyribonuclease.
- DFFA wikiPageWikiLink Gene.
- DFFA wikiPageWikiLink Helix.
- DFFA wikiPageWikiLink Protein.
- DFFA wikiPageWikiLink Protein_domain.
- DFFA wikiPageWikiLink Protein_folding.
- DFFA wikiPageWikiLink Protein–protein_interaction.
- DFFA wikiPageWikiLinkText "DFFA".
- DFFA wikiPageWikiLinkText "ICAD".
- DFFA wikiPageWikiLinkText "Inhibitor of caspase-activated DNase (ICAD)".
- DFFA wikiPageWikiLinkText "inhibitor of caspase-activated DNase".
- DFFA caption "nmr structure of dff-c domain".
- DFFA interpro "IPR015121".
- DFFA name "DNA Fragmentation factor 45kDa, C terminal domain".
- DFFA pfam "PF09033".
- DFFA requireManualInspection "no".
- DFFA summaryText "Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor is a heterodimeric protein of 40-kD and 45-kD subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.".
- DFFA symbol "DFF-C".
- DFFA updateCitations "yes".
- DFFA updatePage "yes".
- DFFA updateProteinBox "yes".
- DFFA updateSummary "yes".
- DFFA wikiPageUsesTemplate Template:Cite_journal.
- DFFA wikiPageUsesTemplate Template:Infobox_protein_family.
- DFFA wikiPageUsesTemplate Template:InterPro_content.
- DFFA wikiPageUsesTemplate Template:PBB.
- DFFA wikiPageUsesTemplate Template:PBB_Controls.
- DFFA wikiPageUsesTemplate Template:PBB_Further_reading.
- DFFA wikiPageUsesTemplate Template:PBB_Summary.
- DFFA wikiPageUsesTemplate Template:PDB_Gallery.
- DFFA wikiPageUsesTemplate Template:Refbegin.
- DFFA wikiPageUsesTemplate Template:Refend.
- DFFA wikiPageUsesTemplate Template:Reflist.
- DFFA subject Category:Protein_domains.
- DFFA hypernym Protein.
- DFFA type Biomolecule.
- DFFA type Protein.
- DFFA type Chemical.
- DFFA type Domain.
- DFFA type Thing.
- DFFA type Q206229.
- DFFA type Q8054.
- DFFA comment "DNA fragmentation factor subunit alpha (DFFA), also known as Inhibitor of caspase-activated DNase (ICAD), is a protein that in humans is encoded by the DFFA gene.Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units.".
- DFFA label "DFFA".
- DFFA sameAs Q17913956.
- DFFA sameAs m.03gwrvf.
- DFFA sameAs Q17913956.
- DFFA wasDerivedFrom DFFA?oldid=678271118.
- DFFA depiction PDB_1koy_EBI.jpg.
- DFFA isPrimaryTopicOf DFFA.