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- DAB1 abstract "The Disabled-1 (Dab1) gene encodes a key regulator of Reelin signaling. Reelin is a large glycoprotein secreted by neurons of the developing brain, particularly Cajal-Retzius cells. DAB1 functions downstream of Reln in a signaling pathwaythat controls cell positioning in the developing brain and during adult neurogenesis. It docks to the intracellular part of the Reelin very low density lipoprotein receptor (VLDLR) and apoE receptor type 2 (ApoER2) and becomes tyrosine-phosphorylated following binding of Reelin to cortical neurons. In mice, mutations of Dab1 and Reelin generate identical phenotypes. In humans, Reelin mutations are associated with brain malformations and mental retardation. In mice, Dab1 mutation results in the scrambler mouse phenotype.With a genomic length of 1.1 Mbp for a coding region of 5.5 kb, DAB1 provides a rare example of genomic complexity, which will impede the identification of human mutations.".
- DAB1 entrezgene "1600".
- DAB1 wikiPageExternalLink h_reelinPathway.asp.
- DAB1 wikiPageID "5139079".
- DAB1 wikiPageLength "13842".
- DAB1 wikiPageOutDegree "44".
- DAB1 wikiPageRevisionID "660999873".
- DAB1 wikiPageWikiLink ASPM_(gene).
- DAB1 wikiPageWikiLink Apolipoprotein.
- DAB1 wikiPageWikiLink Autism.
- DAB1 wikiPageWikiLink Cajal–Retzius_cell.
- DAB1 wikiPageWikiLink Category:Central_nervous_system.
- DAB1 wikiPageWikiLink Category:Human_genes.
- DAB1 wikiPageWikiLink Category:Molecular_neuroscience.
- DAB1 wikiPageWikiLink Category:Peripheral_membrane_proteins.
- DAB1 wikiPageWikiLink Category:Phosphoproteins.
- DAB1 wikiPageWikiLink Cell_signaling.
- DAB1 wikiPageWikiLink Central_nervous_system_disease.
- DAB1 wikiPageWikiLink Cerebellum.
- DAB1 wikiPageWikiLink Cerebral_cortex.
- DAB1 wikiPageWikiLink Cognition.
- DAB1 wikiPageWikiLink Cornell_University.
- DAB1 wikiPageWikiLink Downregulation_and_upregulation.
- DAB1 wikiPageWikiLink Dr._Scott_Williamson.
- DAB1 wikiPageWikiLink Gene_knockout.
- DAB1 wikiPageWikiLink Glycoprotein.
- DAB1 wikiPageWikiLink Han_Chinese.
- DAB1 wikiPageWikiLink Hippocampus.
- DAB1 wikiPageWikiLink In_situ_hybridization.
- DAB1 wikiPageWikiLink Intellectual_disability.
- DAB1 wikiPageWikiLink LDL_receptor.
- DAB1 wikiPageWikiLink Lissencephaly.
- DAB1 wikiPageWikiLink Low-density_lipoprotein_receptor-related_protein_8.
- DAB1 wikiPageWikiLink Mutation.
- DAB1 wikiPageWikiLink Neurogenesis.
- DAB1 wikiPageWikiLink Phenotype.
- DAB1 wikiPageWikiLink Phosphoprotein.
- DAB1 wikiPageWikiLink Pioneer_neuron.
- DAB1 wikiPageWikiLink Purkinje_cell.
- DAB1 wikiPageWikiLink Receptor_(biochemistry).
- DAB1 wikiPageWikiLink Reeler.
- DAB1 wikiPageWikiLink Reelin.
- DAB1 wikiPageWikiLink Schizophrenia.
- DAB1 wikiPageWikiLink Scrambler_mouse.
- DAB1 wikiPageWikiLink Signal_transduction.
- DAB1 wikiPageWikiLink Tyrosine_kinase.
- DAB1 wikiPageWikiLink VLDL_receptor.
- DAB1 wikiPageWikiLink Very_low-density_lipoprotein.
- DAB1 wikiPageWikiLink Yotari.
- DAB1 wikiPageWikiLinkText "DAB1".
- DAB1 wikiPageWikiLinkText "Dab1".
- DAB1 wikiPageWikiLinkText "disabled 1".
- DAB1 wikiPageWikiLinkText "key intracellular adaptor".
- DAB1 wikiPageUsesTemplate Template:Cite_journal.
- DAB1 wikiPageUsesTemplate Template:MeshName.
- DAB1 wikiPageUsesTemplate Template:PBB.
- DAB1 wikiPageUsesTemplate Template:Refbegin.
- DAB1 wikiPageUsesTemplate Template:Refend.
- DAB1 wikiPageUsesTemplate Template:Reflist.
- DAB1 wikiPageUsesTemplate Template:UMichOPM.
- DAB1 subject Category:Central_nervous_system.
- DAB1 subject Category:Human_genes.
- DAB1 subject Category:Molecular_neuroscience.
- DAB1 subject Category:Peripheral_membrane_proteins.
- DAB1 subject Category:Phosphoproteins.
- DAB1 type Biomolecule.
- DAB1 type Protein.
- DAB1 type Thing.
- DAB1 type Q206229.
- DAB1 type Q8054.
- DAB1 comment "The Disabled-1 (Dab1) gene encodes a key regulator of Reelin signaling. Reelin is a large glycoprotein secreted by neurons of the developing brain, particularly Cajal-Retzius cells. DAB1 functions downstream of Reln in a signaling pathwaythat controls cell positioning in the developing brain and during adult neurogenesis.".
- DAB1 label "DAB1".
- DAB1 sameAs Q14916487.
- DAB1 sameAs m.0d4k9k.
- DAB1 sameAs DAB1.
- DAB1 sameAs DAB1.
- DAB1 sameAs Q14916487.
- DAB1 wasDerivedFrom DAB1?oldid=660999873.
- DAB1 isPrimaryTopicOf DAB1.