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- Cytolethal_distending_toxin abstract "Cytolethal distending toxins (abbreviated CDTs) are a class of heterotrimeric toxins produced by certain gram-negative bacteria that display DNase activity. These toxins trigger G2/M cell cycle arrest in specific mammalian cell lines, leading to the enlarged or distended cells for which these toxins are named. Affected cells die by apoptosis.Each toxin consists of three distinct subunits named alphabetically in the order that their coding genes appear in the cdt operon. Cytolethal distending toxins are classified as AB toxins, with an active (\"A\") subunit that directly damages DNA and a binding (\"B\") subunit that helps the toxin attach to the target cells. CdtB is the active subunit and a homolog to mammalian DNase I, whereas CdtA and CdtC make up the binding subunit.Cytolethal distending toxins are produced by gram-negative pathogenic bacteria from the phylum Proteobacteria. Many of these bacteria, including Shigella dysenteriae, Haemophilus ducreyi, and Escherichia coli, infect humans. Bacteria that produce CDTs often persistently colonize their host.".
- Cytolethal_distending_toxin symbol "CDT".
- Cytolethal_distending_toxin thumbnail PDB_protein_1sr4_(HdCDT).jpg?width=300.
- Cytolethal_distending_toxin wikiPageID "32240777".
- Cytolethal_distending_toxin wikiPageLength "16036".
- Cytolethal_distending_toxin wikiPageOutDegree "65".
- Cytolethal_distending_toxin wikiPageRevisionID "678773325".
- Cytolethal_distending_toxin wikiPageWikiLink AB_toxin.
- Cytolethal_distending_toxin wikiPageWikiLink Aggregatibacter_actinomycetemcomitans.
- Cytolethal_distending_toxin wikiPageWikiLink Apoptosis.
- Cytolethal_distending_toxin wikiPageWikiLink Campylobacter_jejuni.
- Cytolethal_distending_toxin wikiPageWikiLink Campylobacter_upsaliensis.
- Cytolethal_distending_toxin wikiPageWikiLink Category:Toxins.
- Cytolethal_distending_toxin wikiPageWikiLink Cell_cycle.
- Cytolethal_distending_toxin wikiPageWikiLink Chancroids.
- Cytolethal_distending_toxin wikiPageWikiLink Deoxyribonuclease.
- Cytolethal_distending_toxin wikiPageWikiLink Deoxyribonuclease_I.
- Cytolethal_distending_toxin wikiPageWikiLink Dysentery.
- Cytolethal_distending_toxin wikiPageWikiLink Endothelium.
- Cytolethal_distending_toxin wikiPageWikiLink Enterocolitis.
- Cytolethal_distending_toxin wikiPageWikiLink Epithelium.
- Cytolethal_distending_toxin wikiPageWikiLink Escherichia_coli.
- Cytolethal_distending_toxin wikiPageWikiLink Fibroblast.
- Cytolethal_distending_toxin wikiPageWikiLink Genotoxicity.
- Cytolethal_distending_toxin wikiPageWikiLink Gram-negative_bacteria.
- Cytolethal_distending_toxin wikiPageWikiLink Haemophilus_ducreyi.
- Cytolethal_distending_toxin wikiPageWikiLink Heterosexuality.
- Cytolethal_distending_toxin wikiPageWikiLink Homology_(biology).
- Cytolethal_distending_toxin wikiPageWikiLink Immortalised_cell_line.
- Cytolethal_distending_toxin wikiPageWikiLink In_vitro.
- Cytolethal_distending_toxin wikiPageWikiLink In_vivo.
- Cytolethal_distending_toxin wikiPageWikiLink Keratinocyte.
- Cytolethal_distending_toxin wikiPageWikiLink Lymphocyte.
- Cytolethal_distending_toxin wikiPageWikiLink Mitosis.
- Cytolethal_distending_toxin wikiPageWikiLink Molecular_microbiology.
- Cytolethal_distending_toxin wikiPageWikiLink Operon.
- Cytolethal_distending_toxin wikiPageWikiLink Pathogen.
- Cytolethal_distending_toxin wikiPageWikiLink Peptide.
- Cytolethal_distending_toxin wikiPageWikiLink Periodontitis.
- Cytolethal_distending_toxin wikiPageWikiLink Phosphatase.
- Cytolethal_distending_toxin wikiPageWikiLink Phosphodiester_bond.
- Cytolethal_distending_toxin wikiPageWikiLink Phylum.
- Cytolethal_distending_toxin wikiPageWikiLink Point_mutation.
- Cytolethal_distending_toxin wikiPageWikiLink Protein_trimer.
- Cytolethal_distending_toxin wikiPageWikiLink Proteobacteria.
- Cytolethal_distending_toxin wikiPageWikiLink Salmonella_enterica.
- Cytolethal_distending_toxin wikiPageWikiLink Shigella.
- Cytolethal_distending_toxin wikiPageWikiLink Shigella_dysenteriae.
- Cytolethal_distending_toxin wikiPageWikiLink Toxin.
- Cytolethal_distending_toxin wikiPageWikiLink Typhoid_fever.
- Cytolethal_distending_toxin wikiPageWikiLink Wikt:tripartite.
- Cytolethal_distending_toxin wikiPageWikiLinkText "Cytolethal distending toxin".
- Cytolethal_distending_toxin wikiPageWikiLinkText "cytolethal distending toxin".
- Cytolethal_distending_toxin caption "Crystal structure of the fully assembled Haemophilus ducreyi cytolethal distending toxin".
- Cytolethal_distending_toxin interpro "IPR003558".
- Cytolethal_distending_toxin name "Cytolethal distending toxin".
- Cytolethal_distending_toxin pfam "PF03498".
- Cytolethal_distending_toxin pfamClan "CL0066".
- Cytolethal_distending_toxin symbol "CDT".
- Cytolethal_distending_toxin wikiPageUsesTemplate Template:Infobox_protein_family.
- Cytolethal_distending_toxin wikiPageUsesTemplate Template:Reflist.
- Cytolethal_distending_toxin subject Category:Toxins.
- Cytolethal_distending_toxin hypernym Toxins.
- Cytolethal_distending_toxin type Biomolecule.
- Cytolethal_distending_toxin type Protein.
- Cytolethal_distending_toxin type Biomolecule.
- Cytolethal_distending_toxin type Chemical.
- Cytolethal_distending_toxin type Toxin.
- Cytolethal_distending_toxin type Thing.
- Cytolethal_distending_toxin type Q206229.
- Cytolethal_distending_toxin type Q8054.
- Cytolethal_distending_toxin comment "Cytolethal distending toxins (abbreviated CDTs) are a class of heterotrimeric toxins produced by certain gram-negative bacteria that display DNase activity. These toxins trigger G2/M cell cycle arrest in specific mammalian cell lines, leading to the enlarged or distended cells for which these toxins are named. Affected cells die by apoptosis.Each toxin consists of three distinct subunits named alphabetically in the order that their coding genes appear in the cdt operon.".
- Cytolethal_distending_toxin label "Cytolethal distending toxin".
- Cytolethal_distending_toxin sameAs Q5201358.
- Cytolethal_distending_toxin sameAs m.0gy086n.
- Cytolethal_distending_toxin sameAs Q5201358.
- Cytolethal_distending_toxin wasDerivedFrom Cytolethal_distending_toxin?oldid=678773325.
- Cytolethal_distending_toxin depiction PDB_protein_1sr4_(HdCDT).jpg.
- Cytolethal_distending_toxin isPrimaryTopicOf Cytolethal_distending_toxin.