Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Cytokine_release_syndrome> ?p ?o }
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- Cytokine_release_syndrome abstract "Cytokine release syndrome is a common immediate complication occurring with the use of anti-T cell antibody infusions such as ATG, OKT3, and TGN1412, but also with the CD-20 antibody rituximab. Severe cases are known as cytokine storms.The pathogenesis is that the antibodies bind to the T cell receptor, activating the T cells before they are destroyed. The cytokines released by the activated T cells produce a type of systemic inflammatory response similar to that found in severe infection characterised by hypotension, pyrexia, and rigors. The patient feels very unwell, as if in a high fever – indeed, the cytokine release syndrome is effectively a type of non-infective fever.Deaths due to cytokine release syndrome with OKT3 (muromonab-CD3) have been reported, and it can cause life-threatening pulmonary edema if the patient is fluid overloaded. However, if treated appropriately it is usually not dangerous, just extremely unpleasant for the patient.The effect is greatly reduced by using low dose OKT3, e.g. 2 mg instead of 5 mg, slow infusion instead of rapid injection, intravenous administration of an anti-histamine (such as chlorphenamine) and a corticosteroid (such as hydrocortisone) prior to starting the ATG/OKT3 infusion, with further doses of anti-histamine and steroid given during the infusion if necessary, acetaminophen 500 mg by mouth 1 hour before infusion to prevent fever. Moreover, it is recommended that any overhydration to be corrected before the administration of the first dose either by dialysis or with intravenous furosemide, to prevent the possible development of pulmonary oedema.".
- Cytokine_release_syndrome wikiPageID "530657".
- Cytokine_release_syndrome wikiPageLength "2363".
- Cytokine_release_syndrome wikiPageOutDegree "24".
- Cytokine_release_syndrome wikiPageRevisionID "705704605".
- Cytokine_release_syndrome wikiPageWikiLink Anti-thymocyte_globulin.
- Cytokine_release_syndrome wikiPageWikiLink Antibody.
- Cytokine_release_syndrome wikiPageWikiLink Antihistamine.
- Cytokine_release_syndrome wikiPageWikiLink Category:Immune_system_disorders.
- Cytokine_release_syndrome wikiPageWikiLink Chlorphenamine.
- Cytokine_release_syndrome wikiPageWikiLink Corticosteroid.
- Cytokine_release_syndrome wikiPageWikiLink Cortisol.
- Cytokine_release_syndrome wikiPageWikiLink Cytokine.
- Cytokine_release_syndrome wikiPageWikiLink Cytokine_storm.
- Cytokine_release_syndrome wikiPageWikiLink Fever.
- Cytokine_release_syndrome wikiPageWikiLink Hypotension.
- Cytokine_release_syndrome wikiPageWikiLink Infection.
- Cytokine_release_syndrome wikiPageWikiLink Muromonab-CD3.
- Cytokine_release_syndrome wikiPageWikiLink Paracetamol.
- Cytokine_release_syndrome wikiPageWikiLink Pulmonary_edema.
- Cytokine_release_syndrome wikiPageWikiLink Rituximab.
- Cytokine_release_syndrome wikiPageWikiLink Shivering.
- Cytokine_release_syndrome wikiPageWikiLink Systemic_inflammatory_response_syndrome.
- Cytokine_release_syndrome wikiPageWikiLink TGN1412.
- Cytokine_release_syndrome wikiPageWikiLink T_cell.
- Cytokine_release_syndrome wikiPageWikiLinkText "Cytokine release syndrome".
- Cytokine_release_syndrome wikiPageWikiLinkText "cytokine release syndrome".
- Cytokine_release_syndrome diseasesdb "34296".
- Cytokine_release_syndrome name "Cytokine release syndrome".
- Cytokine_release_syndrome wikiPageUsesTemplate Template:Infobox_disease.
- Cytokine_release_syndrome wikiPageUsesTemplate Template:Unreferenced.
- Cytokine_release_syndrome subject Category:Immune_system_disorders.
- Cytokine_release_syndrome hypernym Complication.
- Cytokine_release_syndrome type Disease.
- Cytokine_release_syndrome type Disorder.
- Cytokine_release_syndrome type Thing.
- Cytokine_release_syndrome type Q12136.
- Cytokine_release_syndrome comment "Cytokine release syndrome is a common immediate complication occurring with the use of anti-T cell antibody infusions such as ATG, OKT3, and TGN1412, but also with the CD-20 antibody rituximab. Severe cases are known as cytokine storms.The pathogenesis is that the antibodies bind to the T cell receptor, activating the T cells before they are destroyed.".
- Cytokine_release_syndrome label "Cytokine release syndrome".
- Cytokine_release_syndrome sameAs Q3961647.
- Cytokine_release_syndrome sameAs متلازمة_إفراز_السيتوكين.
- Cytokine_release_syndrome sameAs Síndrome_de_liberación_de_citoquinas.
- Cytokine_release_syndrome sameAs Sindrome_da_rilascio_di_citochine.
- Cytokine_release_syndrome sameAs m.02m427.
- Cytokine_release_syndrome sameAs Q3961647.
- Cytokine_release_syndrome wasDerivedFrom Cytokine_release_syndrome?oldid=705704605.
- Cytokine_release_syndrome isPrimaryTopicOf Cytokine_release_syndrome.
- Cytokine_release_syndrome name "Cytokine release syndrome (CRS)".