Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Cyclotraxin_B> ?p ?o }
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- Cyclotraxin_B abstract "Cyclotraxin B (CTX-B) is a small (1200 Da) cyclic peptide and highly potent, selective non-competitive antagonist or negative allosteric modulator of TrkB (IC50 = 0.30 nM), the main receptor of brain-derived neurotrophic factor (BDNF), which itself was derived from BDNF. It crosses the blood-brain-barrier with systemic administration and produces anxiolytic-like effects in animals, though notably not antidepressant-like effects. The compound has also been found to produce analgesic effects in animal models of neuropathic pain. In addition to TrkB, CTX-B has been found to be an allosteric modulator of VEGFR2, one of the receptors of vascular endothelial growth factor (VEGF).".
- Cyclotraxin_B atcPrefix "None".
- Cyclotraxin_B casNumber "1203586-72-4".
- Cyclotraxin_B iupacName "(3S,6R,11R,17S,20S,23S,26S,32S,35S)-6-Amino-20-(4-aminobutyl)-3-(2-amino-2-oxoethyl)-17-(2-carboxyethyl)-23-[(1R)-1-hydroxyethyl]-26-[(4-hydroxyphenyl)methyl]-32-(2-methylsulfanylethyl)-2,5,13,16,19,22,25,28,31,34-decaoxo-8,9-dithia-1,4,12,15,18,21,24,27,30,33-decazabicyclo[33.3.0]octatriacontane-11-carboxylic acid".
- Cyclotraxin_B pubchem "90489002".
- Cyclotraxin_B thumbnail Cyclotraxin_B.svg?width=300.
- Cyclotraxin_B wikiPageID "49040338".
- Cyclotraxin_B wikiPageLength "5582".
- Cyclotraxin_B wikiPageOutDegree "25".
- Cyclotraxin_B wikiPageRevisionID "698983063".
- Cyclotraxin_B wikiPageWikiLink 7,8-Dihydroxyflavone.
- Cyclotraxin_B wikiPageWikiLink ANA-12.
- Cyclotraxin_B wikiPageWikiLink Allosteric_modulator.
- Cyclotraxin_B wikiPageWikiLink Analgesic.
- Cyclotraxin_B wikiPageWikiLink Antidepressant.
- Cyclotraxin_B wikiPageWikiLink Anxiolytic.
- Cyclotraxin_B wikiPageWikiLink Blood–brain_barrier.
- Cyclotraxin_B wikiPageWikiLink Brain-derived_neurotrophic_factor.
- Cyclotraxin_B wikiPageWikiLink Category:Anxiolytics.
- Cyclotraxin_B wikiPageWikiLink Category:Cyclic_peptides.
- Cyclotraxin_B wikiPageWikiLink Category:TrkB_antagonists.
- Cyclotraxin_B wikiPageWikiLink Cyclic_peptide.
- Cyclotraxin_B wikiPageWikiLink Deoxygedunin.
- Cyclotraxin_B wikiPageWikiLink HIOC.
- Cyclotraxin_B wikiPageWikiLink K252a.
- Cyclotraxin_B wikiPageWikiLink Kinase_insert_domain_receptor.
- Cyclotraxin_B wikiPageWikiLink LM22A-4.
- Cyclotraxin_B wikiPageWikiLink Model_organism.
- Cyclotraxin_B wikiPageWikiLink Neuropathic_pain.
- Cyclotraxin_B wikiPageWikiLink Non-competitive_antagonist.
- Cyclotraxin_B wikiPageWikiLink Receptor_(biochemistry).
- Cyclotraxin_B wikiPageWikiLink Systemic_administration.
- Cyclotraxin_B wikiPageWikiLink Tropomyosin_receptor_kinase_B.
- Cyclotraxin_B wikiPageWikiLink Vascular_endothelial_growth_factor.
- Cyclotraxin_B wikiPageWikiLinkText "Cyclotraxin B".
- Cyclotraxin_B atcPrefix "None".
- Cyclotraxin_B c "48".
- Cyclotraxin_B casNumber "1203586".
- Cyclotraxin_B chemspiderid "29785020".
- Cyclotraxin_B h "73".
- Cyclotraxin_B inchi "InChI=1S/C48H73N13O17S3/c1-2439-4658-284356-294152-21-3755-3323-81-80-22-274059-324761-16-5-7-344557-304253-20-3654-3118-25-8-10-2611-9-25/h8-11,24,27-34,39,62-63H,3-7,12-23,49-50H2,1-2H3,/t24-,27+,28+,29+,30+,31+,32+,33+,34+,39+/m1/s1".
- Cyclotraxin_B inchikey "JLBMMJHZUYBFGX-ZHTCEXBHSA-N".
- Cyclotraxin_B iupacName "-6".
- Cyclotraxin_B molecularWeight "1200.36512".
- Cyclotraxin_B n "13".
- Cyclotraxin_B o "17".
- Cyclotraxin_B pubchem "90489002".
- Cyclotraxin_B s "3".
- Cyclotraxin_B smiles "CCO".
- Cyclotraxin_B stdinchi "1".
- Cyclotraxin_B stdinchikey "JLBMMJHZUYBFGX-ZHTCEXBHSA-N".
- Cyclotraxin_B wikiPageUsesTemplate Template:Drugbox.
- Cyclotraxin_B wikiPageUsesTemplate Template:Nervous-system-drug-stub.
- Cyclotraxin_B wikiPageUsesTemplate Template:Neurotrophinergics.
- Cyclotraxin_B wikiPageUsesTemplate Template:Reflist.
- Cyclotraxin_B subject Category:Anxiolytics.
- Cyclotraxin_B subject Category:Cyclic_peptides.
- Cyclotraxin_B subject Category:TrkB_antagonists.
- Cyclotraxin_B hypernym Peptide.
- Cyclotraxin_B type ChemicalCompound.
- Cyclotraxin_B type ChemicalSubstance.
- Cyclotraxin_B type Drug.
- Cyclotraxin_B type ChemicalObject.
- Cyclotraxin_B type Thing.
- Cyclotraxin_B type Q8386.
- Cyclotraxin_B comment "Cyclotraxin B (CTX-B) is a small (1200 Da) cyclic peptide and highly potent, selective non-competitive antagonist or negative allosteric modulator of TrkB (IC50 = 0.30 nM), the main receptor of brain-derived neurotrophic factor (BDNF), which itself was derived from BDNF. It crosses the blood-brain-barrier with systemic administration and produces anxiolytic-like effects in animals, though notably not antidepressant-like effects.".
- Cyclotraxin_B label "Cyclotraxin B".
- Cyclotraxin_B wasDerivedFrom Cyclotraxin_B?oldid=698983063.
- Cyclotraxin_B depiction Cyclotraxin_B.svg.
- Cyclotraxin_B isPrimaryTopicOf Cyclotraxin_B.