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- CspA_mRNA_5_UTR abstract "cspA mRNA 5' UTR is the untranslated region of the cspA gene, which is important in the cold shock response in Enterobacteriales such as E. coli. The 5' UTR element acts as an RNA thermometer, regulating the expression of cspA in response to temperature. By regulating temperature, cspA proteins carry out the vital function of homeostasis. The 5' UTR was first suspected to be significant when mutations within this region of cspA significantly increased the stability of the transcript at 37°C.The secondary structure of cspA mRNA changes in response to temperature; at 37°C the transcript is unstable and less efficiently translated than at lower temperatures. Unlike other RNA thermometers (such as FourU), the secondary structure is not reliant on the melting of a hairpin in order to affect gene expression. Instead, in temperatures below 20°C a cis-regulatory region of ncRNA in the 5' UTR of cspA presents the Shine-Dalgarno sequence and AUG start codon to the ribosome in a more accessible way. The precise mechanism for changing the mRNA conformation is unknown. cspA protein is then produced in significantly higher quantities, making up over 2% of the cell's proteome during cold shock. cspA protein binds Hfq, which upregulates production of sigma factors which mediate a stress response.".
- CspA_mRNA_5_UTR thumbnail CspA_5UTR.png?width=300.
- CspA_mRNA_5_UTR wikiPageExternalLink S0022283603007320.
- CspA_mRNA_5_UTR wikiPageExternalLink 1250378.
- CspA_mRNA_5_UTR wikiPageExternalLink pmidlookup?view=long&pmid=2404279.
- CspA_mRNA_5_UTR wikiPageExternalLink openurl?genre=article&sid=nlm:pubmed&issn=0168-6445&date=2006&volume=30&issue=1&spage=3.
- CspA_mRNA_5_UTR wikiPageID "28126754".
- CspA_mRNA_5_UTR wikiPageLength "5505".
- CspA_mRNA_5_UTR wikiPageOutDegree "27".
- CspA_mRNA_5_UTR wikiPageRevisionID "694474118".
- CspA_mRNA_5_UTR wikiPageWikiLink Category:Cis-regulatory_RNA_elements.
- CspA_mRNA_5_UTR wikiPageWikiLink Category:Non-coding_RNA.
- CspA_mRNA_5_UTR wikiPageWikiLink Cis-Regulatory_element.
- CspA_mRNA_5_UTR wikiPageWikiLink Cold_shock_response.
- CspA_mRNA_5_UTR wikiPageWikiLink Enterobacteriales.
- CspA_mRNA_5_UTR wikiPageWikiLink Escherichia_coli.
- CspA_mRNA_5_UTR wikiPageWikiLink Five_prime_untranslated_region.
- CspA_mRNA_5_UTR wikiPageWikiLink FourU_thermometer.
- CspA_mRNA_5_UTR wikiPageWikiLink Gene_expression.
- CspA_mRNA_5_UTR wikiPageWikiLink Hfq_binding_sRNA.
- CspA_mRNA_5_UTR wikiPageWikiLink Hfq_protein.
- CspA_mRNA_5_UTR wikiPageWikiLink Homeostasis.
- CspA_mRNA_5_UTR wikiPageWikiLink Messenger_RNA.
- CspA_mRNA_5_UTR wikiPageWikiLink Mutant.
- CspA_mRNA_5_UTR wikiPageWikiLink Proteome.
- CspA_mRNA_5_UTR wikiPageWikiLink RNA_thermometer.
- CspA_mRNA_5_UTR wikiPageWikiLink Repression_of_heat_shock_gene_expression_(ROSE)_element.
- CspA_mRNA_5_UTR wikiPageWikiLink Ribosome.
- CspA_mRNA_5_UTR wikiPageWikiLink Shine-Dalgarno_sequence.
- CspA_mRNA_5_UTR wikiPageWikiLink Sigma_factor.
- CspA_mRNA_5_UTR wikiPageWikiLink Start_codon.
- CspA_mRNA_5_UTR wikiPageWikiLink Stem-loop.
- CspA_mRNA_5_UTR wikiPageWikiLink Thermoregulation.
- CspA_mRNA_5_UTR wikiPageWikiLink Translation_(biology).
- CspA_mRNA_5_UTR wikiPageWikiLinkText "CspA mRNA 5' UTR".
- CspA_mRNA_5_UTR wikiPageWikiLinkText "CspA mRNA".
- CspA_mRNA_5_UTR caption "300.0".
- CspA_mRNA_5_UTR id "RF01766".
- CspA_mRNA_5_UTR name "300.0".
- CspA_mRNA_5_UTR name "cspA thermoregulator".
- CspA_mRNA_5_UTR rfam "RF01766".
- CspA_mRNA_5_UTR rnaType "Cis-reg; Thermoregulator;".
- CspA_mRNA_5_UTR symbol "cspA 5'UTR".
- CspA_mRNA_5_UTR taxDomain Enterobacteriales.
- CspA_mRNA_5_UTR wikiPageUsesTemplate Template:Cite_journal.
- CspA_mRNA_5_UTR wikiPageUsesTemplate Template:Infobox_rfam.
- CspA_mRNA_5_UTR wikiPageUsesTemplate Template:Refbegin.
- CspA_mRNA_5_UTR wikiPageUsesTemplate Template:Refend.
- CspA_mRNA_5_UTR wikiPageUsesTemplate Template:Reflist.
- CspA_mRNA_5_UTR wikiPageUsesTemplate Template:Rfam.
- CspA_mRNA_5_UTR subject Category:Cis-regulatory_RNA_elements.
- CspA_mRNA_5_UTR subject Category:Non-coding_RNA.
- CspA_mRNA_5_UTR hypernym Region.
- CspA_mRNA_5_UTR type Settlement.
- CspA_mRNA_5_UTR type Element.
- CspA_mRNA_5_UTR comment "cspA mRNA 5' UTR is the untranslated region of the cspA gene, which is important in the cold shock response in Enterobacteriales such as E. coli. The 5' UTR element acts as an RNA thermometer, regulating the expression of cspA in response to temperature. By regulating temperature, cspA proteins carry out the vital function of homeostasis.".
- CspA_mRNA_5_UTR label "CspA mRNA 5' UTR".
- CspA_mRNA_5_UTR sameAs Q5191592.
- CspA_mRNA_5_UTR sameAs m.0cm8qwv.
- CspA_mRNA_5_UTR sameAs Q5191592.
- CspA_mRNA_5_UTR wasDerivedFrom CspA_mRNA_5_UTR?oldid=694474118.
- CspA_mRNA_5_UTR depiction CspA_5UTR.png.
- CspA_mRNA_5_UTR isPrimaryTopicOf CspA_mRNA_5_UTR.