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- Creb_binding_domain abstract "In molecular biology, the creb binding domain is a protein domain. It is the interlocking domain of the eukaryotic nuclear receptor coactivators CREBBP and P300. This interlocking domain forms a 3-helical non-globular array that forms interlocked heterodimers with its target.Nuclear receptors are ligand-activated transcription factors involved in the regulation of many processes, including development, reproduction and homeostasis. Nuclear receptor coactivators act to modulate the function of nuclear receptors. Coactivators associate with promoters and enhancers primarily through protein-protein contacts to facilitate the interaction between DNA-bound transcription factors and the transcription machinery. Many of these coactivators are structurally related, including CBP (CREB-binding protein, CREBBP) and P300. CBP and P300 both have histone acetyltransferase activity. CBP/P300 proteins function synergistically to activate transcription, acting to remodel chromatin and to recruit RNA polymerase II and the basal transcription machinery. CBP is required for proper cell cycle control, differentiation and apoptosis. The interaction of CBP/P300 with transcription factors involves several small domains. The IBiD domain in the C-terminal of CBP is responsible for CBP interaction with IRF-3, as well as with the adenoviral oncoprotein E1A, TIF-2 coactivator, and the IRF homologue KSHV IRF-1.".
- Creb_binding_domain symbol "Creb_binding".
- Creb_binding_domain thumbnail PDB_1zoq_EBI.jpg?width=300.
- Creb_binding_domain wikiPageID "32345601".
- Creb_binding_domain wikiPageLength "3061".
- Creb_binding_domain wikiPageOutDegree "37".
- Creb_binding_domain wikiPageRevisionID "593871637".
- Creb_binding_domain wikiPageWikiLink Adenoviridae.
- Creb_binding_domain wikiPageWikiLink Apoptosis.
- Creb_binding_domain wikiPageWikiLink CREB-binding_protein.
- Creb_binding_domain wikiPageWikiLink Category:Protein_domains.
- Creb_binding_domain wikiPageWikiLink Cell_cycle.
- Creb_binding_domain wikiPageWikiLink Cell_nucleus.
- Creb_binding_domain wikiPageWikiLink Cellular_differentiation.
- Creb_binding_domain wikiPageWikiLink Chromatin.
- Creb_binding_domain wikiPageWikiLink DNA.
- Creb_binding_domain wikiPageWikiLink EP300.
- Creb_binding_domain wikiPageWikiLink Enhancer_(genetics).
- Creb_binding_domain wikiPageWikiLink Eukaryote.
- Creb_binding_domain wikiPageWikiLink Histone_acetyltransferase.
- Creb_binding_domain wikiPageWikiLink Homeostasis.
- Creb_binding_domain wikiPageWikiLink Homology_(biology).
- Creb_binding_domain wikiPageWikiLink IRF1.
- Creb_binding_domain wikiPageWikiLink IRF3.
- Creb_binding_domain wikiPageWikiLink Interlocking.
- Creb_binding_domain wikiPageWikiLink Ligand.
- Creb_binding_domain wikiPageWikiLink Nuclear_receptor_coactivator_2.
- Creb_binding_domain wikiPageWikiLink Oncogene.
- Creb_binding_domain wikiPageWikiLink Promoter_(genetics).
- Creb_binding_domain wikiPageWikiLink Protein.
- Creb_binding_domain wikiPageWikiLink Protein_dimer.
- Creb_binding_domain wikiPageWikiLink Protein_domain.
- Creb_binding_domain wikiPageWikiLink Protein–protein_interaction.
- Creb_binding_domain wikiPageWikiLink RNA_polymerase_II.
- Creb_binding_domain wikiPageWikiLink Receptor_(biochemistry).
- Creb_binding_domain wikiPageWikiLink Regulation.
- Creb_binding_domain wikiPageWikiLink Synergy.
- Creb_binding_domain wikiPageWikiLink Transcription_(genetics).
- Creb_binding_domain wikiPageWikiLink Transcription_factor.
- Creb_binding_domain caption "irf3-cbp complex".
- Creb_binding_domain interpro "IPR014744".
- Creb_binding_domain name "Creb binding".
- Creb_binding_domain pfam "PF09030".
- Creb_binding_domain symbol "Creb_binding".
- Creb_binding_domain wikiPageUsesTemplate Template:Infobox_protein_family.
- Creb_binding_domain wikiPageUsesTemplate Template:InterPro_content.
- Creb_binding_domain wikiPageUsesTemplate Template:Orphan.
- Creb_binding_domain wikiPageUsesTemplate Template:Reflist.
- Creb_binding_domain subject Category:Protein_domains.
- Creb_binding_domain hypernym Domain.
- Creb_binding_domain type Biomolecule.
- Creb_binding_domain type Protein.
- Creb_binding_domain type Chemical.
- Creb_binding_domain type Domain.
- Creb_binding_domain type Thing.
- Creb_binding_domain type Q206229.
- Creb_binding_domain type Q8054.
- Creb_binding_domain comment "In molecular biology, the creb binding domain is a protein domain. It is the interlocking domain of the eukaryotic nuclear receptor coactivators CREBBP and P300. This interlocking domain forms a 3-helical non-globular array that forms interlocked heterodimers with its target.Nuclear receptors are ligand-activated transcription factors involved in the regulation of many processes, including development, reproduction and homeostasis.".
- Creb_binding_domain label "Creb binding domain".
- Creb_binding_domain sameAs Q5183674.
- Creb_binding_domain sameAs m.0gyrqbq.
- Creb_binding_domain sameAs Q5183674.
- Creb_binding_domain wasDerivedFrom Creb_binding_domain?oldid=593871637.
- Creb_binding_domain depiction PDB_1zoq_EBI.jpg.
- Creb_binding_domain isPrimaryTopicOf Creb_binding_domain.