Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Cortisone_reductase_deficiency> ?p ?o }
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- Cortisone_reductase_deficiency abstract "Cortisone reductase deficiency is caused by dysregulation of the 11β-hydroxysteroid dehydrogenase type 1 enzyme (11β-HSD1), otherwise known as cortisone reductase, a bi-directional enzyme, which catalyzes the interconversion of cortisone to cortisol in the presence of NADH as a co-factor. If levels of NADH are low, the enzyme catalyses the reverse reaction, from cortisol to cortisone, using NAD+ as a co-factor. Cortisol is a glucocorticoid that plays a variety of roles in many different biochemical pathways, including, but not limited to: gluconeogenesis, suppressing immune system responses and carbohydrate metabolism. One of the symptoms of cortisone reductase deficiency is hyperandrogenism, resulting from activation of the Hypothalamic–pituitary–adrenal axis.The deficiency has been known to exhibit symptoms of other disorders such as Polycystic Ovary Syndrome in women. Cortisone Reductase Deficiency alone has been reported in fewer than ten cases in total, all but one case were women. Elevated activity of 11β-HSD1 can lead to obesity or Type II Diabetes, because of the role of cortisol in carbohydrate metabolism and gluconeogenesis.".
- Cortisone_reductase_deficiency thumbnail PDB_1xu7_EBI.jpg?width=300.
- Cortisone_reductase_deficiency wikiPageID "41245210".
- Cortisone_reductase_deficiency wikiPageLength "9746".
- Cortisone_reductase_deficiency wikiPageOutDegree "23".
- Cortisone_reductase_deficiency wikiPageRevisionID "682866245".
- Cortisone_reductase_deficiency wikiPageWikiLink 11β-hydroxysteroid_dehydrogenase_type_1.
- Cortisone_reductase_deficiency wikiPageWikiLink Adrenocorticotropic_hormone.
- Cortisone_reductase_deficiency wikiPageWikiLink Antiandrogen.
- Cortisone_reductase_deficiency wikiPageWikiLink Category:Articles_created_via_the_Article_Wizard.
- Cortisone_reductase_deficiency wikiPageWikiLink Category:Enzyme_defects.
- Cortisone_reductase_deficiency wikiPageWikiLink Cortisol.
- Cortisone_reductase_deficiency wikiPageWikiLink Cortisone.
- Cortisone_reductase_deficiency wikiPageWikiLink Gonadotropin.
- Cortisone_reductase_deficiency wikiPageWikiLink H6PD.
- Cortisone_reductase_deficiency wikiPageWikiLink Hyperandrogenism.
- Cortisone_reductase_deficiency wikiPageWikiLink Hypothalamic–pituitary–adrenal_axis.
- Cortisone_reductase_deficiency wikiPageWikiLink Luteinizing_hormone.
- Cortisone_reductase_deficiency wikiPageWikiLink Polycystic_ovary_syndrome.
- Cortisone_reductase_deficiency wikiPageWikiLink File:Cortisone_Reductase_Deficiency_effects_on_HPA_and_body.png.
- Cortisone_reductase_deficiency wikiPageWikiLink File:Cortisone_Reductase_Deficiency_effects_on_HPA_and_body_in_presence_of_deficient_H6PD.png.
- Cortisone_reductase_deficiency wikiPageWikiLink File:PDB_1xu7_EBI.jpg.
- Cortisone_reductase_deficiency wikiPageWikiLinkText "Cortisone reductase deficiency".
- Cortisone_reductase_deficiency wikiPageUsesTemplate Template:Reflist.
- Cortisone_reductase_deficiency subject Category:Articles_created_via_the_Article_Wizard.
- Cortisone_reductase_deficiency subject Category:Enzyme_defects.
- Cortisone_reductase_deficiency comment "Cortisone reductase deficiency is caused by dysregulation of the 11β-hydroxysteroid dehydrogenase type 1 enzyme (11β-HSD1), otherwise known as cortisone reductase, a bi-directional enzyme, which catalyzes the interconversion of cortisone to cortisol in the presence of NADH as a co-factor. If levels of NADH are low, the enzyme catalyses the reverse reaction, from cortisol to cortisone, using NAD+ as a co-factor.".
- Cortisone_reductase_deficiency label "Cortisone reductase deficiency".
- Cortisone_reductase_deficiency sameAs Q17084678.
- Cortisone_reductase_deficiency sameAs m.0zg71vh.
- Cortisone_reductase_deficiency sameAs Q17084678.
- Cortisone_reductase_deficiency wasDerivedFrom Cortisone_reductase_deficiency?oldid=682866245.
- Cortisone_reductase_deficiency depiction PDB_1xu7_EBI.jpg.
- Cortisone_reductase_deficiency isPrimaryTopicOf Cortisone_reductase_deficiency.