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- Corticotropin-releasing_hormone_antagonist abstract "A Corticotropin-releasing hormone antagonist is a specific type of receptor antagonist that blocks the receptor sites for Corticotropin-releasing hormone (also known as Corticotropin-releasing factor (CRF)), thereby blocking the consequent secretions of ACTH and cortisol. There are four subtypes of this receptor known at present, defined as CRF-1, CRF-2a, CRF-2b, and CRF-2g. Three of these receptors are expressed only in the brain, CRF-1 in the cortex and cerebrum, CRF-2a in the lateral septum and hypothalamus, and CRF-2g in the amygdala. CRF-2b is expressed in the choroid plexus and cerebral arterioles in the brain, but is expressed mainly peripherally on the heart and skeletal muscle tissue.The main research into CRF antagonists to date has focused on antagonists selective for the CRF-1 subtype. Several antagonists for this receptor have been developed and are widely used in research, with the best-known agents being the selective CRF-1 antagonist antalarmin and a newer drug pexacerfont, although several other ligands for this receptor are used in research, such as LWH-234, CP-154,526, NBI-27914 and R-121,919. Antagonists acting at CRF-2 have also been developed, such as the peptide Astressin-B, but so far no highly selective agents for the different CRF-2 subtypes are available.It's been shown that \"the effect of footshock on reinstatement of alcohol seeking is block by systemic, ventricular, or intra-median raphe injections of CRF receptor antagonists.\",mnk,".
- Corticotropin-releasing_hormone_antagonist wikiPageID "16455074".
- Corticotropin-releasing_hormone_antagonist wikiPageLength "2597".
- Corticotropin-releasing_hormone_antagonist wikiPageOutDegree "10".
- Corticotropin-releasing_hormone_antagonist wikiPageRevisionID "707650741".
- Corticotropin-releasing_hormone_antagonist wikiPageWikiLink Adrenocorticotropic_hormone.
- Corticotropin-releasing_hormone_antagonist wikiPageWikiLink Antalarmin.
- Corticotropin-releasing_hormone_antagonist wikiPageWikiLink Astressin-B.
- Corticotropin-releasing_hormone_antagonist wikiPageWikiLink CP-154,526.
- Corticotropin-releasing_hormone_antagonist wikiPageWikiLink Category:CRF-1_antagonists.
- Corticotropin-releasing_hormone_antagonist wikiPageWikiLink Category:Corticotropin-releasing_hormone.
- Corticotropin-releasing_hormone_antagonist wikiPageWikiLink Corticotropin-releasing_hormone.
- Corticotropin-releasing_hormone_antagonist wikiPageWikiLink Cortisol.
- Corticotropin-releasing_hormone_antagonist wikiPageWikiLink Pexacerfont.
- Corticotropin-releasing_hormone_antagonist wikiPageWikiLink Receptor_antagonist.
- Corticotropin-releasing_hormone_antagonist wikiPageWikiLinkText "Corticotropin-releasing hormone antagonist".
- Corticotropin-releasing_hormone_antagonist wikiPageWikiLinkText "corticotropin-releasing hormone antagonist".
- Corticotropin-releasing_hormone_antagonist wikiPageUsesTemplate Template:Biochemistry-stub.
- Corticotropin-releasing_hormone_antagonist wikiPageUsesTemplate Template:Hormone_antagonists.
- Corticotropin-releasing_hormone_antagonist wikiPageUsesTemplate Template:Neuropeptidergics.
- Corticotropin-releasing_hormone_antagonist subject Category:CRF-1_antagonists.
- Corticotropin-releasing_hormone_antagonist subject Category:Corticotropin-releasing_hormone.
- Corticotropin-releasing_hormone_antagonist hypernym Type.
- Corticotropin-releasing_hormone_antagonist type Antagonist.
- Corticotropin-releasing_hormone_antagonist type Neuropeptide.
- Corticotropin-releasing_hormone_antagonist comment "A Corticotropin-releasing hormone antagonist is a specific type of receptor antagonist that blocks the receptor sites for Corticotropin-releasing hormone (also known as Corticotropin-releasing factor (CRF)), thereby blocking the consequent secretions of ACTH and cortisol. There are four subtypes of this receptor known at present, defined as CRF-1, CRF-2a, CRF-2b, and CRF-2g.".
- Corticotropin-releasing_hormone_antagonist label "Corticotropin-releasing hormone antagonist".
- Corticotropin-releasing_hormone_antagonist sameAs Q5173294.
- Corticotropin-releasing_hormone_antagonist sameAs m.03y6c2l.
- Corticotropin-releasing_hormone_antagonist sameAs Q5173294.
- Corticotropin-releasing_hormone_antagonist wasDerivedFrom Corticotropin-releasing_hormone_antagonist?oldid=707650741.
- Corticotropin-releasing_hormone_antagonist isPrimaryTopicOf Corticotropin-releasing_hormone_antagonist.