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- Contrabiotic abstract "Contrabiotics are soluble plant fibers that have a beneficial effect on the gut by blocking potentially harmful interactions between microbes and/or their components and the intestinal epithelium. This is distinct from and unrelated to any prebiotic effect, ie an effect that is mediated by promotion of the growth of “healthy” probiotic bacteria. A contrabiotic effect was first noted for plantain (banana ie Musa spp) fiber which inhibited the adherence of Crohn’s disease mucosal E. coli isolates to intestinal epithelial cells. It was later shown to be an effect of some but not all soluble fibers from other dietary sources – eg broccoli is also contrabiotic but leek and apple fibers are probably not. The contrabiotic effect was shown not only to block bacterial adherence to the epithelium but also to block bacterial translocation across the specialized M (microfold) cells that overlie Peyer’s patches. The effect has been confirmed with a range of commensal and pathogenic bacteria including E. coli, Salmonella Typhimurium, Shigella sonnei, and Clostridium difficile. Studies have shown that the contrabiotic effect results from interaction between the soluble fiber and the gut epithelial cell and that it is the pectin component of the fiber that has most activity. The only direct in vivo study to confirm this to date has been a demonstration that addition of soluble plantain (banana) fiber to chicken feed significantly protected the chickens from invasion by Salmonella. In humans there is also indirect evidence (from the Nurses Health Study in the USA) that a diet high in fruit fiber (but not vegetable or cereal fiber) is protective against subsequent development of Crohn’s disease. It is plausible but unproven that the same contrabiotic effect may be partly responsible for the protective effect of fiber against colorectal cancer, since there is growing evidence for a role of bacteria-epithelial interaction in this cancer.".
- Contrabiotic wikiPageID "49635244".
- Contrabiotic wikiPageLength "7541".
- Contrabiotic wikiPageOutDegree "15".
- Contrabiotic wikiPageRevisionID "708258758".
- Contrabiotic wikiPageWikiLink Category:Medicinal_plants.
- Contrabiotic wikiPageWikiLink Clostridium_difficile_(bacteria).
- Contrabiotic wikiPageWikiLink Colorectal_cancer.
- Contrabiotic wikiPageWikiLink Cooking_plantain.
- Contrabiotic wikiPageWikiLink Crohns_disease.
- Contrabiotic wikiPageWikiLink Escherichia_coli.
- Contrabiotic wikiPageWikiLink Gut.
- Contrabiotic wikiPageWikiLink Intestinal_epithelium.
- Contrabiotic wikiPageWikiLink Pectin.
- Contrabiotic wikiPageWikiLink Prebiotic.
- Contrabiotic wikiPageWikiLink Probiotic.
- Contrabiotic wikiPageWikiLink Salmonella_enterica_subsp._enterica.
- Contrabiotic wikiPageWikiLink Shigella_sonnei.
- Contrabiotic wikiPageWikiLinkText "contrabiotic".
- Contrabiotic wikiPageUsesTemplate Template:Reflist.
- Contrabiotic subject Category:Medicinal_plants.
- Contrabiotic hypernym Fibers.
- Contrabiotic type Brain.
- Contrabiotic comment "Contrabiotics are soluble plant fibers that have a beneficial effect on the gut by blocking potentially harmful interactions between microbes and/or their components and the intestinal epithelium. This is distinct from and unrelated to any prebiotic effect, ie an effect that is mediated by promotion of the growth of “healthy” probiotic bacteria. A contrabiotic effect was first noted for plantain (banana ie Musa spp) fiber which inhibited the adherence of Crohn’s disease mucosal E.".
- Contrabiotic label "Contrabiotic".
- Contrabiotic wasDerivedFrom Contrabiotic?oldid=708258758.
- Contrabiotic isPrimaryTopicOf Contrabiotic.