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- Continuous_erythropoietin_receptor_activator abstract "Continuous erythropoietin receptor activator (CERA) is the generic term for drugs in a new class of third-generation erythropoiesis-stimulating agents (ESAs). In the media, these agents are commonly referred to as 'EPO', short for erythropoietin. CERAs have an extended half-life and a mechanism of action that promotes increased stimulation of erythropoietin receptors compared with other ESAs.Under the trade name Mircera, Roche Pharmaceuticals received approval from the U.S. FDA in January 2008 to market a continuous erythropoiesis receptor activator (methoxy polyethylene glycol-epoetin beta) for the treatment of anemia in patients with chronic kidney disease, including in those undergoing dialysis. (Patent disputes between Amgen, which owns several patents relating to recombinant EPO variants, and Roche are blocking distribution of Mircera in the U.S. This issue appears to have been resolved since Fresenius Medical dialysis clinics in the US are now administering this drug.)Methoxy polyethylene glycol-epoetin beta previously was approved by the European Commission in August 2007, and was made available in Europe at the start of 2008.In terms of its structure, Mircera is similar to the previous synthetic EPO drugs, except that it is connected to a chemical called polyethylene glycol (PEG), which makes it last longer in the body. According to Roche, the product has the longest half-life of all FDA-approved erythropoiesis-stimulating agents (ESAs): up to 6 times longer than darbepoetin alfa and up to 20 times longer than epoetin. CERAs thus promise both lower dosing—significant owing to the high inherent cost of manufacturing recombinant protein drugs—and less frequent injections for patients. ESAs are administered via subcutaneous injections, often in doctor's offices for patients who lack the skill or dexterity to inject themselves, so the once- or twice-monthly dosing regimen for CERAs promises fewer costly, inconvenient office visits for patients requiring constant hemoglobin level maintenance for chronic kidney disease.In clinical trials, CERA dosed every 3 to 4 weeks demonstrated efficacy similar to that of epoetin alfa and darbepoetin alfa in maintaining hemoglobin concentrations within the target hemoglobin range. CERA has generally been well tolerated in clinical trials.".
- Continuous_erythropoietin_receptor_activator wikiPageID "18486827".
- Continuous_erythropoietin_receptor_activator wikiPageLength "5792".
- Continuous_erythropoietin_receptor_activator wikiPageOutDegree "33".
- Continuous_erythropoietin_receptor_activator wikiPageRevisionID "687546570".
- Continuous_erythropoietin_receptor_activator wikiPageWikiLink 2008_Summer_Olympics.
- Continuous_erythropoietin_receptor_activator wikiPageWikiLink 2008_Tour_de_France.
- Continuous_erythropoietin_receptor_activator wikiPageWikiLink Anemia.
- Continuous_erythropoietin_receptor_activator wikiPageWikiLink Bernhard_Kohl.
- Continuous_erythropoietin_receptor_activator wikiPageWikiLink Category:Erythropoiesis-stimulating_agents.
- Continuous_erythropoietin_receptor_activator wikiPageWikiLink Chronic_kidney_disease.
- Continuous_erythropoietin_receptor_activator wikiPageWikiLink Danilo_Di_Luca.
- Continuous_erythropoietin_receptor_activator wikiPageWikiLink Davide_Rebellin.
- Continuous_erythropoietin_receptor_activator wikiPageWikiLink Dialysis.
- Continuous_erythropoietin_receptor_activator wikiPageWikiLink Don_Catlin.
- Continuous_erythropoietin_receptor_activator wikiPageWikiLink Doping_in_sport.
- Continuous_erythropoietin_receptor_activator wikiPageWikiLink Equine_drug_testing.
- Continuous_erythropoietin_receptor_activator wikiPageWikiLink Erik_Tysse.
- Continuous_erythropoietin_receptor_activator wikiPageWikiLink Erythropoiesis-stimulating_agent.
- Continuous_erythropoietin_receptor_activator wikiPageWikiLink Erythropoietin.
- Continuous_erythropoietin_receptor_activator wikiPageWikiLink European_Commission.
- Continuous_erythropoietin_receptor_activator wikiPageWikiLink Giro_dItalia.
- Continuous_erythropoietin_receptor_activator wikiPageWikiLink Hemoglobin.
- Continuous_erythropoietin_receptor_activator wikiPageWikiLink Hoffmann-La_Roche.
- Continuous_erythropoietin_receptor_activator wikiPageWikiLink International_Association_of_Athletics_Federations.
- Continuous_erythropoietin_receptor_activator wikiPageWikiLink International_Olympic_Committee.
- Continuous_erythropoietin_receptor_activator wikiPageWikiLink Leonardo_Piepoli.
- Continuous_erythropoietin_receptor_activator wikiPageWikiLink Methoxy_polyethylene_glycol-epoetin_beta.
- Continuous_erythropoietin_receptor_activator wikiPageWikiLink Non-governmental_organization.
- Continuous_erythropoietin_receptor_activator wikiPageWikiLink Polka_dot.
- Continuous_erythropoietin_receptor_activator wikiPageWikiLink Polyethylene_glycol.
- Continuous_erythropoietin_receptor_activator wikiPageWikiLink Rashid_Ramzi.
- Continuous_erythropoietin_receptor_activator wikiPageWikiLink Riccardo_Riccò.
- Continuous_erythropoietin_receptor_activator wikiPageWikiLink Stefan_Schumacher.
- Continuous_erythropoietin_receptor_activator wikiPageWikiLink Union_Cycliste_Internationale.
- Continuous_erythropoietin_receptor_activator wikiPageWikiLinkText "CERA".
- Continuous_erythropoietin_receptor_activator wikiPageWikiLinkText "Cera".
- Continuous_erythropoietin_receptor_activator wikiPageWikiLinkText "Continuous erythropoietin receptor activator".
- Continuous_erythropoietin_receptor_activator wikiPageWikiLinkText "continuous erythropoietin receptor activator".
- Continuous_erythropoietin_receptor_activator wikiPageUsesTemplate Template:Citation_needed.
- Continuous_erythropoietin_receptor_activator wikiPageUsesTemplate Template:Empty_section.
- Continuous_erythropoietin_receptor_activator wikiPageUsesTemplate Template:Reflist.
- Continuous_erythropoietin_receptor_activator subject Category:Erythropoiesis-stimulating_agents.
- Continuous_erythropoietin_receptor_activator hypernym Term.
- Continuous_erythropoietin_receptor_activator type Agent.
- Continuous_erythropoietin_receptor_activator type Drug.
- Continuous_erythropoietin_receptor_activator type Agent.
- Continuous_erythropoietin_receptor_activator type Drug.
- Continuous_erythropoietin_receptor_activator comment "Continuous erythropoietin receptor activator (CERA) is the generic term for drugs in a new class of third-generation erythropoiesis-stimulating agents (ESAs). In the media, these agents are commonly referred to as 'EPO', short for erythropoietin. CERAs have an extended half-life and a mechanism of action that promotes increased stimulation of erythropoietin receptors compared with other ESAs.Under the trade name Mircera, Roche Pharmaceuticals received approval from the U.S.".
- Continuous_erythropoietin_receptor_activator label "Continuous erythropoietin receptor activator".
- Continuous_erythropoietin_receptor_activator sameAs Q2914445.
- Continuous_erythropoietin_receptor_activator sameAs CERA.
- Continuous_erythropoietin_receptor_activator sameAs CERA_(fármaco).
- Continuous_erythropoietin_receptor_activator sameAs Cera.
- Continuous_erythropoietin_receptor_activator sameAs CERA.
- Continuous_erythropoietin_receptor_activator sameAs CERA.
- Continuous_erythropoietin_receptor_activator sameAs 持続性エリスロポエチン受容体活性化剤.
- Continuous_erythropoietin_receptor_activator sameAs Cera_(epovariant).
- Continuous_erythropoietin_receptor_activator sameAs Continuous_erythropoietin_receptor_activator.
- Continuous_erythropoietin_receptor_activator sameAs m.04f0mdq.
- Continuous_erythropoietin_receptor_activator sameAs Q2914445.
- Continuous_erythropoietin_receptor_activator wasDerivedFrom Continuous_erythropoietin_receptor_activator?oldid=687546570.
- Continuous_erythropoietin_receptor_activator isPrimaryTopicOf Continuous_erythropoietin_receptor_activator.