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- Complexin abstract "In molecular biology, complexin (also known as synaphin), a eukaryotic specific protein, is a cytoplasmic neuronal protein which binds to the SNARE protein complex (SNAREpin) with a high affinity. In the presence of Ca2+, the transport vesicle protein synaptotagmin displaces complexin, allowing the SNARE protein complex to bind the transport vesicle to the presynaptic membrane.Complexin acts as both an inhibitor and a facilitator of synaptic vesicle fusion and neurotransmitter release. In one conformation, it clamps SNAREpin complexes, preventing vesicle fusion, while in a different conformation it releases the SNAREpins, allowing synaptotagmin to trigger fusion.Whereas complexin is not necessary for synaptic vesicle exocytosis, it does increase neurotransmitter release by 60–70% as demonstrated by complexin gene knockout in mice. A number of human neurological diseases have been linked to a deficiency of complexin.".
- Complexin wikiPageID "12409082".
- Complexin wikiPageLength "10253".
- Complexin wikiPageOutDegree "26".
- Complexin wikiPageRevisionID "678243992".
- Complexin wikiPageWikiLink Alpha_helix.
- Complexin wikiPageWikiLink Category:Proteins.
- Complexin wikiPageWikiLink Depolarization.
- Complexin wikiPageWikiLink Eukaryote.
- Complexin wikiPageWikiLink Exocytosis.
- Complexin wikiPageWikiLink Molecular_biology.
- Complexin wikiPageWikiLink N-terminus.
- Complexin wikiPageWikiLink Neuron.
- Complexin wikiPageWikiLink Neurotransmitter.
- Complexin wikiPageWikiLink Protein.
- Complexin wikiPageWikiLink SNARE_(protein).
- Complexin wikiPageWikiLink Synapse.
- Complexin wikiPageWikiLink Synaptic_vesicle.
- Complexin wikiPageWikiLink Synaptotagmin_1.
- Complexin wikiPageWikiLink Vesicle_(biology_and_chemistry).
- Complexin wikiPageWikiLinkText "Complexin".
- Complexin wikiPageWikiLinkText "complexin".
- Complexin wikiPageUsesTemplate Template:Gene.
- Complexin subject Category:Proteins.
- Complexin hypernym Protein.
- Complexin type Biomolecule.
- Complexin type Protein.
- Complexin type Biomolecule.
- Complexin type Nutrient.
- Complexin type Page.
- Complexin comment "In molecular biology, complexin (also known as synaphin), a eukaryotic specific protein, is a cytoplasmic neuronal protein which binds to the SNARE protein complex (SNAREpin) with a high affinity. In the presence of Ca2+, the transport vesicle protein synaptotagmin displaces complexin, allowing the SNARE protein complex to bind the transport vesicle to the presynaptic membrane.Complexin acts as both an inhibitor and a facilitator of synaptic vesicle fusion and neurotransmitter release.".
- Complexin label "Complexin".
- Complexin sameAs Q5156621.
- Complexin sameAs m.02w41kr.
- Complexin sameAs Q5156621.
- Complexin wasDerivedFrom Complexin?oldid=678243992.
- Complexin isPrimaryTopicOf Complexin.