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- Comparative_genomic_hybridization abstract "Comparative genomic hybridization is a molecular cytogenetic method for analysing copy number variations (CNVs) relative to ploidy level in the DNA of a test sample compared to a reference sample, without the need for culturing cells. The aim of this technique is to quickly and efficiently compare two genomic DNA samples arising from two sources, which are most often closely related, because it is suspected that they contain differences in terms of either gains or losses of either whole chromosomes or subchromosomal regions (a portion of a whole chromosome). This technique was originally developed for the evaluation of the differences between the chromosomal complements of solid tumor and normal tissue, and has an improved resoIution of 5-10 megabases compared to the more traditional cytogenetic analysis techniques of giemsa banding and fluorescence in situ hybridization (FISH) which are limited by the resolution of the microscope utilized.This is achieved through the use of competitive fluorescence in situ hybridization. In short, this involves the isolation of DNA from the two sources to be compared, most commonly a test and reference source, independent labelling of each DNA sample with a different fluorophores (fluorescent molecules) of different colours (usually red and green), denaturation of the DNA so that it is single stranded, and the hybridization of the two resultant samples in a 1:1 ratio to a normal metaphase spread of chromosomes, to which the labelled DNA samples will bind at their locus of origin. Using a fluorescence microscope and computer software, the differentially coloured fluorescent signals are then compared along the length of each chromosome for identification of chromosomal differences between the two sources. A higher intensity of the test sample colour in a specific region of a chromosome indicates the gain of material of that region in the corresponding source sample, while a higher intensity of the reference sample colour indicates the loss of material in the test sample in that specific region. A neutral colour (yellow when the fluorophore labels are red and green) indicates no difference between the two samples in that location.CGH is only able to detect unbalanced chromosomal abnormalities. This is because balanced chromosomal abnormalities such as reciprocal translocations, inversions or ring chromosomes do not affect copy number, which is what is detected by CGH technologies. CGH does, however, allow for the exploration of all 46 human chromosomes in single test and the discovery of deletions and duplications, even on the microscopic scale which may lead to the identification of candidate genes to be further explored by other cytological techniques.Through the use of DNA microarrays in conjunction with CGH techniques, the more specific form of array CGH (aCGH) has been developed, allowing for a locus-by-locus measure of CNV with increased resolution as low as 100 kilobases. This improved technique allows for the aetiology of known and unknown conditions to be discovered.".
- Comparative_genomic_hybridization thumbnail CGH_schema.jpg?width=300.
- Comparative_genomic_hybridization wikiPageExternalLink ?tech_m=cCGH,aCGH.
- Comparative_genomic_hybridization wikiPageExternalLink www.arraymap.org.
- Comparative_genomic_hybridization wikiPageExternalLink CMA.
- Comparative_genomic_hybridization wikiPageExternalLink CGH-Microarray-Service.html.
- Comparative_genomic_hybridization wikiPageExternalLink query.fcgi?db=cancerchromosomes.
- Comparative_genomic_hybridization wikiPageExternalLink www.progenetix.org.
- Comparative_genomic_hybridization wikiPageID "983601".
- Comparative_genomic_hybridization wikiPageLength "40720".
- Comparative_genomic_hybridization wikiPageOutDegree "132".
- Comparative_genomic_hybridization wikiPageRevisionID "696084862".
- Comparative_genomic_hybridization wikiPageWikiLink Acetic_acid.
- Comparative_genomic_hybridization wikiPageWikiLink Affinity_chromatography.
- Comparative_genomic_hybridization wikiPageWikiLink Aneuploidy.
- Comparative_genomic_hybridization wikiPageWikiLink Antibody.
- Comparative_genomic_hybridization wikiPageWikiLink Apochromat.
- Comparative_genomic_hybridization wikiPageWikiLink Aqueous_solution.
- Comparative_genomic_hybridization wikiPageWikiLink Bacterial_artificial_chromosome.
- Comparative_genomic_hybridization wikiPageWikiLink Base_pair.
- Comparative_genomic_hybridization wikiPageWikiLink Cancer.
- Comparative_genomic_hybridization wikiPageWikiLink Candidate_gene.
- Comparative_genomic_hybridization wikiPageWikiLink Category:Cytogenetics.
- Comparative_genomic_hybridization wikiPageWikiLink Category:Gene_tests.
- Comparative_genomic_hybridization wikiPageWikiLink Category:Molecular_genetics.
- Comparative_genomic_hybridization wikiPageWikiLink Centromere.
- Comparative_genomic_hybridization wikiPageWikiLink Chromatid.
- Comparative_genomic_hybridization wikiPageWikiLink Chromosomal_inversion.
- Comparative_genomic_hybridization wikiPageWikiLink Chromosomal_translocation.
- Comparative_genomic_hybridization wikiPageWikiLink Chromosome.
- Comparative_genomic_hybridization wikiPageWikiLink Chromosome_abnormality.
- Comparative_genomic_hybridization wikiPageWikiLink Comparative_genomic_hybridization.
- Comparative_genomic_hybridization wikiPageWikiLink Complementary_DNA.
- Comparative_genomic_hybridization wikiPageWikiLink Confidence_interval.
- Comparative_genomic_hybridization wikiPageWikiLink Congenital_disorder.
- Comparative_genomic_hybridization wikiPageWikiLink Copy-number_variation.
- Comparative_genomic_hybridization wikiPageWikiLink Covalent_bond.
- Comparative_genomic_hybridization wikiPageWikiLink Cri_du_chat.
- Comparative_genomic_hybridization wikiPageWikiLink Cyanine.
- Comparative_genomic_hybridization wikiPageWikiLink Cytogenetics.
- Comparative_genomic_hybridization wikiPageWikiLink DAPI.
- Comparative_genomic_hybridization wikiPageWikiLink DNA.
- Comparative_genomic_hybridization wikiPageWikiLink DNA_microarray.
- Comparative_genomic_hybridization wikiPageWikiLink Degeneracy_(biology).
- Comparative_genomic_hybridization wikiPageWikiLink Deletion_(genetics).
- Comparative_genomic_hybridization wikiPageWikiLink Denaturation_(biochemistry).
- Comparative_genomic_hybridization wikiPageWikiLink Diatonic_and_chromatic.
- Comparative_genomic_hybridization wikiPageWikiLink Down_syndrome.
- Comparative_genomic_hybridization wikiPageWikiLink Ethanol_precipitation.
- Comparative_genomic_hybridization wikiPageWikiLink Ether.
- Comparative_genomic_hybridization wikiPageWikiLink Ethylenediaminetetraacetic_acid.
- Comparative_genomic_hybridization wikiPageWikiLink Fetus.
- Comparative_genomic_hybridization wikiPageWikiLink File:CGH_schema.jpg.
- Comparative_genomic_hybridization wikiPageWikiLink Flow_cytometry.
- Comparative_genomic_hybridization wikiPageWikiLink Fluorescence_in_situ_hybridization.
- Comparative_genomic_hybridization wikiPageWikiLink Fluorescence_microscope.
- Comparative_genomic_hybridization wikiPageWikiLink Fluorophore.
- Comparative_genomic_hybridization wikiPageWikiLink G_banding.
- Comparative_genomic_hybridization wikiPageWikiLink Gel_electrophoresis.
- Comparative_genomic_hybridization wikiPageWikiLink Genetic_imbalance.
- Comparative_genomic_hybridization wikiPageWikiLink Genome.
- Comparative_genomic_hybridization wikiPageWikiLink HR-CGH.
- Comparative_genomic_hybridization wikiPageWikiLink High-resolution_CGH.
- Comparative_genomic_hybridization wikiPageWikiLink Human_Genome_Project.
- Comparative_genomic_hybridization wikiPageWikiLink Hybridization_probe.
- Comparative_genomic_hybridization wikiPageWikiLink In_vitro_fertilisation.
- Comparative_genomic_hybridization wikiPageWikiLink Infant.
- Comparative_genomic_hybridization wikiPageWikiLink Karyotype.
- Comparative_genomic_hybridization wikiPageWikiLink Library_(biology).
- Comparative_genomic_hybridization wikiPageWikiLink Locus_(genetics).
- Comparative_genomic_hybridization wikiPageWikiLink Metaphase.
- Comparative_genomic_hybridization wikiPageWikiLink Metastasis.
- Comparative_genomic_hybridization wikiPageWikiLink Methanol.
- Comparative_genomic_hybridization wikiPageWikiLink Molecular_cloning.
- Comparative_genomic_hybridization wikiPageWikiLink Mosaic_(genetics).
- Comparative_genomic_hybridization wikiPageWikiLink Nick_translation.
- Comparative_genomic_hybridization wikiPageWikiLink Nitrogen.
- Comparative_genomic_hybridization wikiPageWikiLink Normalization_(statistics).
- Comparative_genomic_hybridization wikiPageWikiLink Nucleic_acid.
- Comparative_genomic_hybridization wikiPageWikiLink Nucleic_acid_hybridization.
- Comparative_genomic_hybridization wikiPageWikiLink Oligonucleotide.
- Comparative_genomic_hybridization wikiPageWikiLink Phenol.
- Comparative_genomic_hybridization wikiPageWikiLink Phenol_extraction.
- Comparative_genomic_hybridization wikiPageWikiLink Plasmid.
- Comparative_genomic_hybridization wikiPageWikiLink Ploidy.
- Comparative_genomic_hybridization wikiPageWikiLink Polymerase_chain_reaction.
- Comparative_genomic_hybridization wikiPageWikiLink Potassium_chloride.
- Comparative_genomic_hybridization wikiPageWikiLink Prader–Willi_syndrome.
- Comparative_genomic_hybridization wikiPageWikiLink Ring_chromosome.
- Comparative_genomic_hybridization wikiPageWikiLink Rolling_circle_replication.
- Comparative_genomic_hybridization wikiPageWikiLink Silicon_dioxide.
- Comparative_genomic_hybridization wikiPageWikiLink Structural_variation.
- Comparative_genomic_hybridization wikiPageWikiLink T-cell_prolymphocytic_leukemia.
- Comparative_genomic_hybridization wikiPageWikiLink Telomere.
- Comparative_genomic_hybridization wikiPageWikiLink Tris.
- Comparative_genomic_hybridization wikiPageWikiLink Virtual_karyotype.
- Comparative_genomic_hybridization wikiPageWikiLink File:ACGH_profile_of_the_IMR32_neuroblastoma_cell_line.svg.
- Comparative_genomic_hybridization wikiPageWikiLink File:Array-CGH_protocol.svg.
- Comparative_genomic_hybridization wikiPageWikiLinkText "CGH".
- Comparative_genomic_hybridization wikiPageWikiLinkText "Comparative genomic hybridization".