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- Codrug abstract "A codrug or mutual prodrug consists of two synergistic drugs chemically linked together, in order to improve the drug delivery properties of one or both drugs. The constituent drugs are indicated for the same disease, but may exert different therapeutic effects via disparate mechanisms of action.Some examples of codrugs include: Sulfasalazine, which is a combination of sulfapyridine and 5-aminosalicylic acid coupled with an azo linkage Benorylate, which is an esterified product of paracetamol and acetylsalicylic acid Sultamicillin, which is an ester of ampicillin and sulbactam Fenethylline, which is a combination of amphetamine and theophyllineAn effective codrug should be pharmacologically inactive in its own right, but should release the constituent drugs upon biochemical breakage of the chemical linkage at the target tissue where their therapeutic effects are needed. As such, the chemical linkage (usually a covalent bond) should be subjectable to biodegradation, such as hydrolysis, by an enzymatic or non-enzymatic mechanism. The differential distribution of enzymes capable of catalyzing the breakage of the chemical linkage in different tissues may be exploited to achieve tissue-specific metabolism of the codrug to release the constituent drugs.".
- Codrug wikiPageID "27608975".
- Codrug wikiPageLength "1819".
- Codrug wikiPageOutDegree "15".
- Codrug wikiPageRevisionID "692536465".
- Codrug wikiPageWikiLink Amphetamine.
- Codrug wikiPageWikiLink Ampicillin.
- Codrug wikiPageWikiLink Aspirin.
- Codrug wikiPageWikiLink Benorilate.
- Codrug wikiPageWikiLink Category:Codrugs.
- Codrug wikiPageWikiLink Covalent_bond.
- Codrug wikiPageWikiLink Fenethylline.
- Codrug wikiPageWikiLink Mesalazine.
- Codrug wikiPageWikiLink Paracetamol.
- Codrug wikiPageWikiLink Prodrug.
- Codrug wikiPageWikiLink Sulbactam.
- Codrug wikiPageWikiLink Sulfapyridine.
- Codrug wikiPageWikiLink Sulfasalazine.
- Codrug wikiPageWikiLink Sultamicillin.
- Codrug wikiPageWikiLink Theophylline.
- Codrug wikiPageWikiLinkText "Codrug".
- Codrug wikiPageWikiLinkText "codrug".
- Codrug wikiPageUsesTemplate Template:Pharm-stub.
- Codrug wikiPageUsesTemplate Template:Reflist.
- Codrug subject Category:Codrugs.
- Codrug type Drug.
- Codrug type Drug.
- Codrug type Concept.
- Codrug comment "A codrug or mutual prodrug consists of two synergistic drugs chemically linked together, in order to improve the drug delivery properties of one or both drugs.".
- Codrug label "Codrug".
- Codrug sameAs Q5140373.
- Codrug sameAs m.0c3x5fq.
- Codrug sameAs Q5140373.
- Codrug wasDerivedFrom Codrug?oldid=692536465.
- Codrug isPrimaryTopicOf Codrug.