Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Cobicistat> ?p ?o }
- Cobicistat abstract "Cobicistat, with trade name Tybost (formerly GS-9350) is a licensed drug for use in the treatment of human immunodeficiency virus infection (HIV/AIDS).Like ritonavir (Norvir), cobicistat is of interest for its ability to inhibit liver enzymes that metabolize other medications used to treat HIV, notably elvitegravir, an HIV integrase inhibitor. By combining cobicistat with elvitegravir, higher concentrations of the latter are achieved in the body with lower dosing, theoretically enhancing elvitegravir's viral suppression while diminishing its adverse side-effects. In contrast with ritonavir, the only other booster approved for use as a part of HAART, cobicistat has no anti-HIV activity of its own.Cobicistat is a component of two four-drug, fixed-dose combination HIV treatments. The first, elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil, is marketed as Stribild and was approved by the FDA in August 2012 for use in the United States. The second, elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide, is marketed as Genvoya and was approved by the FDA in November 2015 for use in the United States. Both Stribild and Genvoya are owned by Gilead Sciences.Additionally, in existence are a fixed-dose combination of cobicistat and protease inhibitor darunavir (darunavir/cobicistat; marketed as Prezcobix by Janssen Therapeutics), and a fixed-dose combination of cobicistat and protease inhibitor atazanavir (atazanavir/cobicistat; marketed as Evotaz by Bristol-Myers Squibb). Both Prezcobix and Evotaz were approved by the FDA in January 2015.Cobicistat is a potent inhibitor of cytochrome P450 3A enzymes, including the important CYP3A4 subtype. It also inhibits intestinal transport proteins, increasing the overall absorption of several HIV medications, including atazanavir, darunavir and tenofovir alafenamide.".
- Cobicistat atcPrefix "V03".
- Cobicistat atcSuffix "AX03".
- Cobicistat casNumber "1004316-88-4".
- Cobicistat chEBI "72291".
- Cobicistat fdaUniiCode "LW2E03M5PG".
- Cobicistat iupacName "1,3-thiazol-5-ylmethyl[(2R,5R)-5-{[(2S)-2-[(methyl{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}carbamoyl)amino]-4-(morpholin-4-yl)butanoyl]amino}-1,6-diphenylhexan-2-yl]carbamate".
- Cobicistat pubchem "25151504".
- Cobicistat thumbnail Cobicistat_structure.svg?width=300.
- Cobicistat wikiPageID "29240014".
- Cobicistat wikiPageLength "5855".
- Cobicistat wikiPageOutDegree "23".
- Cobicistat wikiPageRevisionID "702407537".
- Cobicistat wikiPageWikiLink Atazanavir.
- Cobicistat wikiPageWikiLink Bristol-Myers_Squibb.
- Cobicistat wikiPageWikiLink CYP3A4.
- Cobicistat wikiPageWikiLink Category:Carbamates.
- Cobicistat wikiPageWikiLink Category:Cytochrome_P450_inhibitors.
- Cobicistat wikiPageWikiLink Category:Morpholines.
- Cobicistat wikiPageWikiLink Category:Thiazoles.
- Cobicistat wikiPageWikiLink Category:Ureas.
- Cobicistat wikiPageWikiLink Cytochrome_P450.
- Cobicistat wikiPageWikiLink Darunavir.
- Cobicistat wikiPageWikiLink Elvitegravir.
- Cobicistat wikiPageWikiLink tenofovir.
- Cobicistat wikiPageWikiLink Gilead_Sciences.
- Cobicistat wikiPageWikiLink HIV.
- Cobicistat wikiPageWikiLink AIDS.
- Cobicistat wikiPageWikiLink Integrase_inhibitor.
- Cobicistat wikiPageWikiLink AIDS.
- Cobicistat wikiPageWikiLink Metabolism.
- Cobicistat wikiPageWikiLink Protease_inhibitor_(pharmacology).
- Cobicistat wikiPageWikiLink Ritonavir.
- Cobicistat wikiPageWikiLink Tenofovir_alafenamide.
- Cobicistat wikiPageWikiLinkText "Cobicistat".
- Cobicistat wikiPageWikiLinkText "Tybost".
- Cobicistat wikiPageWikiLinkText "cobicistat".
- Cobicistat atcPrefix "V03".
- Cobicistat atcSuffix "AX03".
- Cobicistat c "40".
- Cobicistat casNumber "1004316".
- Cobicistat chebi "72291".
- Cobicistat chembl "2095208".
- Cobicistat chemspiderid "25084912".
- Cobicistat h "53".
- Cobicistat iupacName "13".
- Cobicistat iupharLigand "7535".
- Cobicistat molecularWeight "776.023".
- Cobicistat n "7".
- Cobicistat o "5".
- Cobicistat pubchem "25151504".
- Cobicistat s "2".
- Cobicistat smiles "CCc1ncCNCNCCNCCc5ccccc5".
- Cobicistat stdinchi "1".
- Cobicistat stdinchikey "ZCIGNRJZKPOIKD-CQXVEOKZSA-N".
- Cobicistat tradename "Tybost".
- Cobicistat unii "LW2E03M5PG".
- Cobicistat verifiedfields "changed".
- Cobicistat verifiedrevid "451564721".
- Cobicistat watchedfields "changed".
- Cobicistat width "275".
- Cobicistat wikiPageUsesTemplate Template:Antiretroviral_drug.
- Cobicistat wikiPageUsesTemplate Template:Cascite.
- Cobicistat wikiPageUsesTemplate Template:Chemspidercite.
- Cobicistat wikiPageUsesTemplate Template:Drugbankcite.
- Cobicistat wikiPageUsesTemplate Template:Drugbox.
- Cobicistat wikiPageUsesTemplate Template:Ebicite.
- Cobicistat wikiPageUsesTemplate Template:Fdacite.
- Cobicistat wikiPageUsesTemplate Template:Reflist.
- Cobicistat wikiPageUsesTemplate Template:Stdinchicite.
- Cobicistat subject Category:Carbamates.
- Cobicistat subject Category:Cytochrome_P450_inhibitors.
- Cobicistat subject Category:Morpholines.
- Cobicistat subject Category:Thiazoles.
- Cobicistat subject Category:Ureas.
- Cobicistat hypernym Drug.
- Cobicistat type ChemicalSubstance.
- Cobicistat type Drug.
- Cobicistat type Amide.
- Cobicistat type Azole.
- Cobicistat type Carbamate.
- Cobicistat type Chemical.
- Cobicistat type Ester.
- Cobicistat type Ether.
- Cobicistat type Heterocycle.
- Cobicistat type Inhibitor.
- Cobicistat type Redirect.
- Cobicistat type ChemicalObject.
- Cobicistat type Thing.
- Cobicistat type Q8386.
- Cobicistat comment "Cobicistat, with trade name Tybost (formerly GS-9350) is a licensed drug for use in the treatment of human immunodeficiency virus infection (HIV/AIDS).Like ritonavir (Norvir), cobicistat is of interest for its ability to inhibit liver enzymes that metabolize other medications used to treat HIV, notably elvitegravir, an HIV integrase inhibitor.".
- Cobicistat label "Cobicistat".
- Cobicistat sameAs Q5138908.
- Cobicistat sameAs كوبيسيستات.
- Cobicistat sameAs Kobisistaatti.
- Cobicistat sameAs Kobicisztát.
- Cobicistat sameAs Cobicistat.
- Cobicistat sameAs m.0dlm3vk.
- Cobicistat sameAs Kobicistat.
- Cobicistat sameAs Kobicistat.