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- Clinical_equipoise abstract "Clinical equipoise, also known as the principle of equipoise, provides the ethical basis for medical research that involves assigning patients to different treatment arms of a clinical trial. The term was first used by Benjamin Freedman in 1987. In short, clinical equipoise means that there is genuine uncertainty in the expert medical community over whether a treatment will be beneficial. This applies also for off-label treatments performed before or during their required clinical trials.An ethical dilemma arises in a clinical trial when the investigator(s) begin to believe that the treatment or intervention administered in one arm of the trial is significantly outperforming the other arms. A trial should begin with a null hypothesis, and there should exist no decisive evidence that the intervention or drug being tested will be superior to existing treatments or effective at all. As the trial progresses, the findings may provide sufficient evidence to convince the investigator of the intervention or drug’s efficacy. Once a certain threshold of evidence is passed, there is no longer genuine uncertainty about the most beneficial treatment, so there is an ethical imperative for the investigator to provide the superior intervention to all participants. Ethicists contest the location of this evidentiary threshold, with some suggesting that investigators should only continue the study until they are convinced that one of the treatments is better, and with others arguing that the study should continue until the evidence convinces the entire expert medical community.The extent to which major research ethics policies endorse clinical equipoise varies. For instance, the Canadian Tri-Council Policy Statement endorses it; whereas, the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) does not. With regard to clinical equipoise in practice, there is evidence that industry-funded studies disproportionately favor the industry product, suggesting unfavorable conditions for clinical equipoise. In contrast, a series of studies of national cancer institute funded trials suggests an outcome pattern consistent with clinical equipoise.".
- Clinical_equipoise wikiPageExternalLink PRA3-PT349,M1.
- Clinical_equipoise wikiPageExternalLink 756.
- Clinical_equipoise wikiPageExternalLink ,.
- Clinical_equipoise wikiPageID "5431669".
- Clinical_equipoise wikiPageLength "7485".
- Clinical_equipoise wikiPageOutDegree "11".
- Clinical_equipoise wikiPageRevisionID "643518123".
- Clinical_equipoise wikiPageWikiLink Category:Ethical_principles.
- Clinical_equipoise wikiPageWikiLink Category:Medical_ethics.
- Clinical_equipoise wikiPageWikiLink Category:Medical_research.
- Clinical_equipoise wikiPageWikiLink Clinical_trial.
- Clinical_equipoise wikiPageWikiLink Empirical_evidence.
- Clinical_equipoise wikiPageWikiLink International_Council_on_Harmonisation_of_Technical_Requirements_for_Registration_of_Pharmaceuticals_for_Human_Use.
- Clinical_equipoise wikiPageWikiLink Null_hypothesis.
- Clinical_equipoise wikiPageWikiLink Randomized_controlled_trial.
- Clinical_equipoise wikiPageWikiLink Robert_M._Veatch.
- Clinical_equipoise wikiPageWikiLink Surgery.
- Clinical_equipoise wikiPageWikiLink Therapeutic_misconception.
- Clinical_equipoise wikiPageWikiLinkText "Clinical Equipoise".
- Clinical_equipoise wikiPageWikiLinkText "Clinical equipoise".
- Clinical_equipoise wikiPageWikiLinkText "clinical equipoise".
- Clinical_equipoise wikiPageUsesTemplate Template:Citation_needed.
- Clinical_equipoise wikiPageUsesTemplate Template:Reflist.
- Clinical_equipoise subject Category:Ethical_principles.
- Clinical_equipoise subject Category:Medical_ethics.
- Clinical_equipoise subject Category:Medical_research.
- Clinical_equipoise comment "Clinical equipoise, also known as the principle of equipoise, provides the ethical basis for medical research that involves assigning patients to different treatment arms of a clinical trial. The term was first used by Benjamin Freedman in 1987. In short, clinical equipoise means that there is genuine uncertainty in the expert medical community over whether a treatment will be beneficial.".
- Clinical_equipoise label "Clinical equipoise".
- Clinical_equipoise sameAs Q2919796.
- Clinical_equipoise sameAs Equilibri_clínic.
- Clinical_equipoise sameAs Indeterminación_clínica.
- Clinical_equipoise sameAs שיווי_משקל_קליני.
- Clinical_equipoise sameAs m.0dlky0.
- Clinical_equipoise sameAs Q2919796.
- Clinical_equipoise wasDerivedFrom Clinical_equipoise?oldid=643518123.
- Clinical_equipoise isPrimaryTopicOf Clinical_equipoise.