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- Clathrin_adaptor_proteins abstract "Proteins synthesized on the ribosome and processed in the endoplasmic reticulum are transported from the Golgi apparatus to the trans-Golgi network (TGN), and from there via small carrier vesicles to their final destination compartment. These vesicles have specific coat proteins (such as clathrin or coatomer) that are important for cargo selection and direction of transport. Clathrin coats contain both clathrin (acts as a scaffold) and adaptor complexes that link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. The two major types of clathrin adaptor complexes are the heterotetrameric adaptor protein (AP) complexes, and the monomeric GGA (Golgi-localising, Gamma-adaptin ear domain homology, ARF-binding proteins) adaptors.AP (adaptor protein) complexes are found in coated vesicles and clathrin-coated pits. AP complexes connect cargo proteins and lipids to clathrin at vesicle budding sites, as well as binding accessory proteins that regulate coat assembly and disassembly (such as AP180, epsins and auxilin). There are different AP complexes in mammals. AP1 is responsible for the transport of lysosomal hydrolases between the TGN and endosomes. AP2 adaptor complex associates with the plasma membrane and is responsible for endocytosis. AP3 is responsible for protein trafficking to lysosomes and other related organelles. AP4 is less well characterised. AP complexes are heterotetramers composed of two large subunits (adaptins), a medium subunit (mu) and a small subunit (sigma). For example, in AP1 these subunits are gamma-1-adaptin, beta-1-adaptin, mu-1 and sigma-1, while in AP2 they are alpha-adaptin, beta-2-adaptin, mu-2 and sigma-2. Each subunit has a specific function. Adaptins recognise and bind to clathrin through their hinge region (clathrin box), and recruit accessory proteins that modulate AP function through their C-terminal ear (appendage) domains. Mu recognises tyrosine-based sorting signals within the cytoplasmic domains of transmembrane cargo proteins. One function of clathrin and AP2 complex-mediated endocytosis is to regulate the number of GABA(A) receptors available at the cell surface .".
- Clathrin_adaptor_proteins symbol "Clat_adaptor_s".
- Clathrin_adaptor_proteins wikiPageID "35666519".
- Clathrin_adaptor_proteins wikiPageLength "6185".
- Clathrin_adaptor_proteins wikiPageOutDegree "48".
- Clathrin_adaptor_proteins wikiPageRevisionID "662158457".
- Clathrin_adaptor_proteins wikiPageWikiLink AP2_adaptor_complex.
- Clathrin_adaptor_proteins wikiPageWikiLink Ap180.
- Clathrin_adaptor_proteins wikiPageWikiLink Auxilin.
- Clathrin_adaptor_proteins wikiPageWikiLink Budding.
- Clathrin_adaptor_proteins wikiPageWikiLink Category:Peripheral_membrane_proteins.
- Clathrin_adaptor_proteins wikiPageWikiLink Category:Protein_families.
- Clathrin_adaptor_proteins wikiPageWikiLink Cell_(biology).
- Clathrin_adaptor_proteins wikiPageWikiLink Cell_membrane.
- Clathrin_adaptor_proteins wikiPageWikiLink Clathrin.
- Clathrin_adaptor_proteins wikiPageWikiLink Concentration.
- Clathrin_adaptor_proteins wikiPageWikiLink Cytoplasm.
- Clathrin_adaptor_proteins wikiPageWikiLink Domain_(biology).
- Clathrin_adaptor_proteins wikiPageWikiLink Endocytosis.
- Clathrin_adaptor_proteins wikiPageWikiLink Endoplasmic_reticulum.
- Clathrin_adaptor_proteins wikiPageWikiLink Endosome.
- Clathrin_adaptor_proteins wikiPageWikiLink Epsin.
- Clathrin_adaptor_proteins wikiPageWikiLink Golgi_apparatus.
- Clathrin_adaptor_proteins wikiPageWikiLink Hydrolase.
- Clathrin_adaptor_proteins wikiPageWikiLink Lipid.
- Clathrin_adaptor_proteins wikiPageWikiLink Lysosome.
- Clathrin_adaptor_proteins wikiPageWikiLink Mammal.
- Clathrin_adaptor_proteins wikiPageWikiLink Molecular_binding.
- Clathrin_adaptor_proteins wikiPageWikiLink Organelle.
- Clathrin_adaptor_proteins wikiPageWikiLink Protein.
- Clathrin_adaptor_proteins wikiPageWikiLink Protein_domain.
- Clathrin_adaptor_proteins wikiPageWikiLink Protein_kinase.
- Clathrin_adaptor_proteins wikiPageWikiLink Protein_subunit.
- Clathrin_adaptor_proteins wikiPageWikiLink Protein–protein_interaction.
- Clathrin_adaptor_proteins wikiPageWikiLink Receptor_(biochemistry).
- Clathrin_adaptor_proteins wikiPageWikiLink Ribosome.
- Clathrin_adaptor_proteins wikiPageWikiLink Signal_transducing_adaptor_protein.
- Clathrin_adaptor_proteins wikiPageWikiLink Signal_transduction.
- Clathrin_adaptor_proteins wikiPageWikiLink Transcriptional_regulation.
- Clathrin_adaptor_proteins wikiPageWikiLink Transport.
- Clathrin_adaptor_proteins wikiPageWikiLink Vesicle_(biology_and_chemistry).
- Clathrin_adaptor_proteins wikiPageWikiLinkText "clathrin box".
- Clathrin_adaptor_proteins wikiPageWikiLinkText "clathrin-adaptor complex".
- Clathrin_adaptor_proteins wikiPageWikiLinkText "clathrin-adaptor".
- Clathrin_adaptor_proteins interpro "IPR022775".
- Clathrin_adaptor_proteins name "Clathrin adaptor complex small chain".
- Clathrin_adaptor_proteins pfam "PF01217".
- Clathrin_adaptor_proteins symbol "Clat_adaptor_s".
- Clathrin_adaptor_proteins wikiPageUsesTemplate Template:ELM.
- Clathrin_adaptor_proteins wikiPageUsesTemplate Template:Infobox_protein_family.
- Clathrin_adaptor_proteins wikiPageUsesTemplate Template:InterPro_content.
- Clathrin_adaptor_proteins wikiPageUsesTemplate Template:Merge.
- Clathrin_adaptor_proteins wikiPageUsesTemplate Template:Reflist.
- Clathrin_adaptor_proteins wikiPageUsesTemplate Template:Vesicular_transport_proteins.
- Clathrin_adaptor_proteins subject Category:Peripheral_membrane_proteins.
- Clathrin_adaptor_proteins subject Category:Protein_families.
- Clathrin_adaptor_proteins type Biomolecule.
- Clathrin_adaptor_proteins type Protein.
- Clathrin_adaptor_proteins type Thing.
- Clathrin_adaptor_proteins type Q206229.
- Clathrin_adaptor_proteins type Q8054.
- Clathrin_adaptor_proteins comment "Proteins synthesized on the ribosome and processed in the endoplasmic reticulum are transported from the Golgi apparatus to the trans-Golgi network (TGN), and from there via small carrier vesicles to their final destination compartment. These vesicles have specific coat proteins (such as clathrin or coatomer) that are important for cargo selection and direction of transport.".
- Clathrin_adaptor_proteins label "Clathrin adaptor proteins".
- Clathrin_adaptor_proteins sameAs Q5128484.
- Clathrin_adaptor_proteins sameAs m.0jl1fb5.
- Clathrin_adaptor_proteins sameAs Q5128484.
- Clathrin_adaptor_proteins wasDerivedFrom Clathrin_adaptor_proteins?oldid=662158457.
- Clathrin_adaptor_proteins isPrimaryTopicOf Clathrin_adaptor_proteins.