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- Citrullination abstract "Citrullination or deimination is the conversion of the amino acid arginine in a protein into the amino acid citrulline. Enzymes called peptidylarginine deiminases (PADs) replace the primary ketimine group (=NH) by a ketone group (=O).Citrullination controls the expression of genes, particularly in the developing embryo. The immune system often attacks citrullinated proteins, leading to autoimmune diseases such as rheumatoid arthritis and multiple sclerosis.Citrulline is not one of the 20 standard amino acids encoded by DNA in the genetic code. Instead, it is the result of a post-translational modification.Citrullination is distinct from the formation of the free amino acid citrulline as part of the urea cycle or as a byproduct of enzymes of the nitric oxide synthase family.Arginine is positively charged at a neutral pH, whereas citrulline is uncharged. This increases the hydrophobicity of the protein, leading to changes in protein folding. Therefore, citrullination can change the structure and function of proteins.Proteins that normally contain citrulline residues include myelin basic protein (MBP), filaggrin, and several histone proteins, while other proteins, like fibrin and vimentin, can get citrullinated during cell-death and tissue inflammation.Fibrin and fibrinogen may be favored sites for arginine deimination within rheumatoid joints. Test for presence of anti-citrullinated protein (ACP) antibodies are highly specific (88-96%) for rheumatoid arthritis (RA), about as sensitive as rheumatoid factor (70-78%) for diagnosis of RA, and are detectable from even before the onset of clinical disease.Citrullinated vimentin may be an autoantigen in RA and other autoimmune diseases, and is used to study RA. Moreover, antibodies against mutated citrullinated vimentin (MCV) may be useful for monitoring effects of RA therapy. An ELISA system utilises genetically modified citrullinated vimentin (MCV), a naturally occurring isoform of vimentin to improve the performance of the test.In the reaction from arginine to citrulline, one of the terminal nitrogen atoms of the arginine side chain is replaced by an oxygen. The reaction uses one water molecule and yields ammonia as a side-product:".
- Citrullination thumbnail Citrullination.svg?width=300.
- Citrullination wikiPageID "4649353".
- Citrullination wikiPageLength "11030".
- Citrullination wikiPageOutDegree "48".
- Citrullination wikiPageRevisionID "690733287".
- Citrullination wikiPageWikiLink Alzheimers_disease.
- Citrullination wikiPageWikiLink Amino_acid.
- Citrullination wikiPageWikiLink Ammonia.
- Citrullination wikiPageWikiLink Anti–citrullinated_protein_antibody.
- Citrullination wikiPageWikiLink Arginine.
- Citrullination wikiPageWikiLink Astrocyte.
- Citrullination wikiPageWikiLink Category:Posttranslational_modification.
- Citrullination wikiPageWikiLink Category:Protein_structure.
- Citrullination wikiPageWikiLink Central_nervous_system.
- Citrullination wikiPageWikiLink Citrulline.
- Citrullination wikiPageWikiLink Demyelinating_disease.
- Citrullination wikiPageWikiLink ELISA.
- Citrullination wikiPageWikiLink Epigenetics.
- Citrullination wikiPageWikiLink Filaggrin.
- Citrullination wikiPageWikiLink Genetic_code.
- Citrullination wikiPageWikiLink Histone.
- Citrullination wikiPageWikiLink Imine.
- Citrullination wikiPageWikiLink Ketone.
- Citrullination wikiPageWikiLink Methylation.
- Citrullination wikiPageWikiLink Microglia.
- Citrullination wikiPageWikiLink Multiple_sclerosis.
- Citrullination wikiPageWikiLink Mutated_citrullinated_vimentin.
- Citrullination wikiPageWikiLink Myelin.
- Citrullination wikiPageWikiLink Myelin_basic_protein.
- Citrullination wikiPageWikiLink Myelinogenesis.
- Citrullination wikiPageWikiLink Neuron.
- Citrullination wikiPageWikiLink Nitric_oxide_synthase.
- Citrullination wikiPageWikiLink Nitrogen.
- Citrullination wikiPageWikiLink Oligodendrocyte.
- Citrullination wikiPageWikiLink Oxygen.
- Citrullination wikiPageWikiLink Phosphorylation.
- Citrullination wikiPageWikiLink Photoreceptor_cell.
- Citrullination wikiPageWikiLink Post-translational_modification.
- Citrullination wikiPageWikiLink Protein_folding.
- Citrullination wikiPageWikiLink Retina.
- Citrullination wikiPageWikiLink Rheumatoid_arthritis.
- Citrullination wikiPageWikiLink Rheumatoid_factor.
- Citrullination wikiPageWikiLink Schwann_cell.
- Citrullination wikiPageWikiLink Side_chain.
- Citrullination wikiPageWikiLink Urea_cycle.
- Citrullination wikiPageWikiLink Vimentin.
- Citrullination wikiPageWikiLink Water.
- Citrullination wikiPageWikiLink File:Citrullination.svg.
- Citrullination wikiPageWikiLinkText "Citrullination".
- Citrullination wikiPageWikiLinkText "citrullination".
- Citrullination wikiPageWikiLinkText "deamination".
- Citrullination wikiPageWikiLinkText "deimination".
- Citrullination wikiPageUsesTemplate Template:Protein_primary_structure.
- Citrullination wikiPageUsesTemplate Template:Reflist.
- Citrullination subject Category:Posttranslational_modification.
- Citrullination subject Category:Protein_structure.
- Citrullination hypernym Conversion.
- Citrullination type VideoGame.
- Citrullination type Biophysic.
- Citrullination comment "Citrullination or deimination is the conversion of the amino acid arginine in a protein into the amino acid citrulline. Enzymes called peptidylarginine deiminases (PADs) replace the primary ketimine group (=NH) by a ketone group (=O).Citrullination controls the expression of genes, particularly in the developing embryo.".
- Citrullination label "Citrullination".
- Citrullination sameAs Q68581.
- Citrullination sameAs Citrulinación.
- Citrullination sameAs シトルリン化.
- Citrullination sameAs Citrullinatie.
- Citrullination sameAs m.0cffml.
- Citrullination sameAs Citrulinacija.
- Citrullination sameAs Citrulinacija.
- Citrullination sameAs Q68581.
- Citrullination wasDerivedFrom Citrullination?oldid=690733287.
- Citrullination depiction Citrullination.svg.
- Citrullination isPrimaryTopicOf Citrullination.