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- Citrate_synthase abstract "The enzyme citrate synthase [E.C. 2.3.3.1 (previously 4.1.3.7)] exists in nearly all living cells and stands as a pace-making enzyme in the first step of the Citric Acid Cycle (or Krebs Cycle). Citrate synthase is localized within eukaryotic cells in the mitochondrial matrix, but is encoded by nuclear DNA rather than mitochondrial. It is synthesized using cytoplasmic ribosomes, then transported into the mitochondrial matrix. Citrate synthase is commonly used as a quantitative enzyme marker for the presence of intact mitochondria.Citrate synthase catalyzes the condensation reaction of the two-carbon acetate residue from acetyl coenzyme A and a molecule of four-carbon oxaloacetate to form the six-carbon citrate: acetyl-CoA + oxaloacetate + H2O → citrate + CoA-SH\t\t\t\tOxaloacetate is regenerated after the completion of one round of the Krebs Cycle.Oxaloacetate is the first substrate to bind to the enzyme. This induces the enzyme to change its conformation, and creates a binding site for the acetyl-CoA. Only when this citroyl-CoA has formed will another conformational change cause thioester hydrolysis and release coenzyme A. This ensures that the energy released from the thioester bond cleavage will drive the condensation.".
- Citrate_synthase entrezgene "1431".
- Citrate_synthase thumbnail Citrate_Synthase_(open_form).png?width=300.
- Citrate_synthase wikiPageID "3830525".
- Citrate_synthase wikiPageLength "7720".
- Citrate_synthase wikiPageOutDegree "51".
- Citrate_synthase wikiPageRevisionID "699059380".
- Citrate_synthase wikiPageWikiLink Acetate.
- Citrate_synthase wikiPageWikiLink Acetyl-CoA.
- Citrate_synthase wikiPageWikiLink Active_site.
- Citrate_synthase wikiPageWikiLink Adenosine_diphosphate.
- Citrate_synthase wikiPageWikiLink Adenosine_triphosphate.
- Citrate_synthase wikiPageWikiLink Aldol_condensation.
- Citrate_synthase wikiPageWikiLink Allosteric_regulation.
- Citrate_synthase wikiPageWikiLink Amino_acid.
- Citrate_synthase wikiPageWikiLink Biomolecular_structure.
- Citrate_synthase wikiPageWikiLink Carbonyl.
- Citrate_synthase wikiPageWikiLink Catalysis.
- Citrate_synthase wikiPageWikiLink Catalytic_triad.
- Citrate_synthase wikiPageWikiLink Category:Cell_biology.
- Citrate_synthase wikiPageWikiLink Category:EC_2.3.3.
- Citrate_synthase wikiPageWikiLink Citric_acid.
- Citrate_synthase wikiPageWikiLink Citric_acid_cycle.
- Citrate_synthase wikiPageWikiLink Citroyl-CoA.
- Citrate_synthase wikiPageWikiLink Coenzyme_A.
- Citrate_synthase wikiPageWikiLink Condensation_reaction.
- Citrate_synthase wikiPageWikiLink DNA.
- Citrate_synthase wikiPageWikiLink Deprotonation.
- Citrate_synthase wikiPageWikiLink Enol.
- Citrate_synthase wikiPageWikiLink Enzyme.
- Citrate_synthase wikiPageWikiLink Eukaryote.
- Citrate_synthase wikiPageWikiLink Hydrolysis.
- Citrate_synthase wikiPageWikiLink Mitochondrial_matrix.
- Citrate_synthase wikiPageWikiLink Mitochondrion.
- Citrate_synthase wikiPageWikiLink Morpheein.
- Citrate_synthase wikiPageWikiLink Nicotinamide_adenine_dinucleotide.
- Citrate_synthase wikiPageWikiLink Nucleophile.
- Citrate_synthase wikiPageWikiLink Nucleophilic_addition.
- Citrate_synthase wikiPageWikiLink Oxaloacetic_acid.
- Citrate_synthase wikiPageWikiLink Properties_of_water.
- Citrate_synthase wikiPageWikiLink Ribosome.
- Citrate_synthase wikiPageWikiLink Succinyl-CoA.
- Citrate_synthase wikiPageWikiLink File:Citrate_Synthase_Mechanism_Drew_Beck_revised_OH.png.
- Citrate_synthase wikiPageWikiLinkText "Citrate synthase".
- Citrate_synthase wikiPageWikiLinkText "citrate synthase".
- Citrate_synthase caption "The Active Site of Citrate Synthase".
- Citrate_synthase casNumber "9027".
- Citrate_synthase ecNumber "2.3".
- Citrate_synthase goCode "4108".
- Citrate_synthase image "Citrate Synthase .png".
- Citrate_synthase image "Citrate synthase Closed form.png".
- Citrate_synthase name "Citrate -synthase".
- Citrate_synthase wikiPageUsesTemplate Template:Acyltransferases.
- Citrate_synthase wikiPageUsesTemplate Template:Citric_acid_cycle_enzymes.
- Citrate_synthase wikiPageUsesTemplate Template:Enzymes.
- Citrate_synthase wikiPageUsesTemplate Template:Infobox_enzyme.
- Citrate_synthase wikiPageUsesTemplate Template:MeshName.
- Citrate_synthase wikiPageUsesTemplate Template:Mitochondrial_enzymes.
- Citrate_synthase wikiPageUsesTemplate Template:Multiple_image.
- Citrate_synthase wikiPageUsesTemplate Template:PBB.
- Citrate_synthase wikiPageUsesTemplate Template:Portal_bar.
- Citrate_synthase wikiPageUsesTemplate Template:Reflist.
- Citrate_synthase subject Category:Cell_biology.
- Citrate_synthase subject Category:EC_2.3.3.
- Citrate_synthase type Biomolecule.
- Citrate_synthase type Protein.
- Citrate_synthase type Thing.
- Citrate_synthase type Q206229.
- Citrate_synthase type Q8054.
- Citrate_synthase comment "The enzyme citrate synthase [E.C. 2.3.3.1 (previously 4.1.3.7)] exists in nearly all living cells and stands as a pace-making enzyme in the first step of the Citric Acid Cycle (or Krebs Cycle). Citrate synthase is localized within eukaryotic cells in the mitochondrial matrix, but is encoded by nuclear DNA rather than mitochondrial. It is synthesized using cytoplasmic ribosomes, then transported into the mitochondrial matrix.".
- Citrate_synthase label "Citrate synthase".
- Citrate_synthase sameAs Q416426.
- Citrate_synthase sameAs Citrat_sintasa.
- Citrate_synthase sameAs Citrátsyntáza.
- Citrate_synthase sameAs Citrat-Synthase.
- Citrate_synthase sameAs Citrato_sintasa.
- Citrate_synthase sameAs Sitraattisyntaasi.
- Citrate_synthase sameAs Citrate_synthase.
- Citrate_synthase sameAs Citrato_sintase.
- Citrate_synthase sameAs Citrát-szintáz.
- Citrate_synthase sameAs Citrato_(Si)-sintasi.
- Citrate_synthase sameAs クエン酸シンターゼ.
- Citrate_synthase sameAs Citraatsynthase.
- Citrate_synthase sameAs Citrato_sintase.
- Citrate_synthase sameAs m.0b25yd.
- Citrate_synthase sameAs Цитратсинтаза.
- Citrate_synthase sameAs Citrat_(Si)-sintaza.
- Citrate_synthase sameAs Citrat_(Si)-sintaza.
- Citrate_synthase sameAs Q416426.
- Citrate_synthase sameAs 柠檬酸合酶.
- Citrate_synthase wasDerivedFrom Citrate_synthase?oldid=699059380.
- Citrate_synthase depiction Citrate_Synthase_(open_form).png.
- Citrate_synthase isPrimaryTopicOf Citrate_synthase.