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- Chromosomal_rearrangement abstract "In genetics, a chromosomal rearrangement is a type of chromosome abnormality involving a change in the structure of the native chromosome. Such changes may involve several different classes of events, like deletions, duplications, inversions, and translocations. Usually, these events are caused by a breakage in the DNA double helices at two different locations, followed by a rejoining of the broken ends to produce a new chromosomal arrangement of genes, different from the gene order of the chromosomes before they were broken. Structural chromosomal abnormalities are estimated to occur in around 0.5% of newborn infants.Some chromosomal regions are more prone to rearrangement than others and thus are the source of genetic diseases and cancer. This instability is usually due to the propensity of these regions to misalign during DNA repair, exacerbated by defects of the appearance of replication proteins (like FEN1 or Pol δ) that ubiquitously affect the integrity of the genome.Complex chromosomal rearrangements (CCR) are rarely seen in the general population and are defined as structural chromosomal rearrangements with at least three breakpoints with exchange of genetic material between two or more chromosomes. Some forms of campomelic dysplasia, for example, result from CCRs.It is possible that speciation frequently occurs when a population becomes fixed for one or more chromosomal rearrangements that reduce fitness when they are heterozygous. This theory is lacking in theoretical support because mutations that cause a large reduction in fitness can only be fixed through genetic drift in small, inbred populations, and the effects of chromosomal rearrangements on fitness are unpredictable and vary greatly in plant and animal species. However, a potential mechanism that could promote speciation is that rearrangements reduce gene flow more by suppressing recombination (and extending the effects of linked isolation genes) than by reducing fitness.".
- Chromosomal_rearrangement wikiPageID "12632610".
- Chromosomal_rearrangement wikiPageLength "4455".
- Chromosomal_rearrangement wikiPageOutDegree "21".
- Chromosomal_rearrangement wikiPageRevisionID "676618133".
- Chromosomal_rearrangement wikiPageWikiLink Campomelic_dysplasia.
- Chromosomal_rearrangement wikiPageWikiLink Category:Chromosomal_abnormalities.
- Chromosomal_rearrangement wikiPageWikiLink Category:Cytogenetics.
- Chromosomal_rearrangement wikiPageWikiLink Chromosomal_inversion.
- Chromosomal_rearrangement wikiPageWikiLink Chromosomal_translocation.
- Chromosomal_rearrangement wikiPageWikiLink Chromosome_abnormality.
- Chromosomal_rearrangement wikiPageWikiLink DNA_polymerase_delta.
- Chromosomal_rearrangement wikiPageWikiLink DNA_repair.
- Chromosomal_rearrangement wikiPageWikiLink Deletion_(genetics).
- Chromosomal_rearrangement wikiPageWikiLink Fitness_(biology).
- Chromosomal_rearrangement wikiPageWikiLink Fixation_(population_genetics).
- Chromosomal_rearrangement wikiPageWikiLink Flap_structure-specific_endonuclease_1.
- Chromosomal_rearrangement wikiPageWikiLink Gene.
- Chromosomal_rearrangement wikiPageWikiLink Gene_duplication.
- Chromosomal_rearrangement wikiPageWikiLink Genetic_drift.
- Chromosomal_rearrangement wikiPageWikiLink Genetic_recombination.
- Chromosomal_rearrangement wikiPageWikiLink Genetics.
- Chromosomal_rearrangement wikiPageWikiLink Inbreeding.
- Chromosomal_rearrangement wikiPageWikiLink Nucleic_acid_double_helix.
- Chromosomal_rearrangement wikiPageWikiLink Speciation.
- Chromosomal_rearrangement wikiPageWikiLink Zygosity.
- Chromosomal_rearrangement wikiPageWikiLinkText "Chromosomal rearrangement".
- Chromosomal_rearrangement wikiPageWikiLinkText "Rearrangement".
- Chromosomal_rearrangement wikiPageWikiLinkText "chromosomal rearrangement".
- Chromosomal_rearrangement wikiPageWikiLinkText "rearrangement".
- Chromosomal_rearrangement wikiPageWikiLinkText "rearrangements".
- Chromosomal_rearrangement wikiPageUsesTemplate Template:Chromo.
- Chromosomal_rearrangement wikiPageUsesTemplate Template:Chromosomal_abnormalities.
- Chromosomal_rearrangement wikiPageUsesTemplate Template:Reflist.
- Chromosomal_rearrangement subject Category:Chromosomal_abnormalities.
- Chromosomal_rearrangement subject Category:Cytogenetics.
- Chromosomal_rearrangement hypernym Abnormality.
- Chromosomal_rearrangement type Disease.
- Chromosomal_rearrangement type Disorder.
- Chromosomal_rearrangement comment "In genetics, a chromosomal rearrangement is a type of chromosome abnormality involving a change in the structure of the native chromosome. Such changes may involve several different classes of events, like deletions, duplications, inversions, and translocations.".
- Chromosomal_rearrangement label "Chromosomal rearrangement".
- Chromosomal_rearrangement sameAs Q5113909.
- Chromosomal_rearrangement sameAs m.0pcghgf.
- Chromosomal_rearrangement sameAs Q5113909.
- Chromosomal_rearrangement wasDerivedFrom Chromosomal_rearrangement?oldid=676618133.
- Chromosomal_rearrangement isPrimaryTopicOf Chromosomal_rearrangement.