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- Cholangiocyte abstract "Cholangiocytes are the epithelial cells of the bile duct. They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts.In the healthy liver, cholangiocytes contribute to bile secretion via net release of bicarbonate and water. Several hormones and locally acting mediators are known to contribute to cholangiocyte fluid/electrolyte secretion. These include secretin, acetylcholine, ATP, and bombesin.Cholangiocytes act through bile-acid independent bile flow, which is driven by the active transport of electrolytes. In contrast, hepatocytes secrete bile through bile-acid dependent bile flow, which is coupled to canalicular secretion of bile acids via ATP-driven transporters. This results in passive transcellular and paracellular secretion of fluid and electrolytes through an osmotic effect.Importantly, cholangiocytes are the target of disease in a variety of conditions often known as \"cholangiopathies\". These diseases include primary biliary cirrhosis, primary sclerosing cholangitis, AIDS cholangiopathy, disappearing bile duct syndromes, Alagille's syndrome, cystic fibrosis, and biliary atresia. As a group, cholangiopathies account for approximately 18% of adult liver transplantations and the majority of pediatric liver transplantations.Active scientific investigation of cholangiocytes focuses on such diverse processes as mechanisms of fluid/electrolyte secretion, regulation of cholangiocyte proliferation, roles of cholangiocytes in the pathogenesis of liver fibrosis and cirrhosis, and cholangiocyte apoptosis. Specific investigation of individual cholangiopathies is also pursued actively.".
- Cholangiocyte wikiPageID "2730519".
- Cholangiocyte wikiPageLength "2624".
- Cholangiocyte wikiPageOutDegree "18".
- Cholangiocyte wikiPageRevisionID "609587613".
- Cholangiocyte wikiPageWikiLink AIDS_cholangiopathy.
- Cholangiocyte wikiPageWikiLink Acetylcholine.
- Cholangiocyte wikiPageWikiLink Adenosine_triphosphate.
- Cholangiocyte wikiPageWikiLink Alagille_syndrome.
- Cholangiocyte wikiPageWikiLink Bile.
- Cholangiocyte wikiPageWikiLink Bile_duct.
- Cholangiocyte wikiPageWikiLink Biliary_atresia.
- Cholangiocyte wikiPageWikiLink Bombesin.
- Cholangiocyte wikiPageWikiLink Category:Digestive_system.
- Cholangiocyte wikiPageWikiLink Category:Epithelial_cells.
- Cholangiocyte wikiPageWikiLink Category:Human_cells.
- Cholangiocyte wikiPageWikiLink Cystic_fibrosis.
- Cholangiocyte wikiPageWikiLink Epithelium.
- Cholangiocyte wikiPageWikiLink Hepatocyte.
- Cholangiocyte wikiPageWikiLink Primary_biliary_cirrhosis.
- Cholangiocyte wikiPageWikiLink Primary_sclerosing_cholangitis.
- Cholangiocyte wikiPageWikiLink Secretin.
- Cholangiocyte wikiPageWikiLink Terminologia_Histologica.
- Cholangiocyte wikiPageWikiLinkText "Cholangiocyte".
- Cholangiocyte wikiPageWikiLinkText "biliary epithelial cells".
- Cholangiocyte wikiPageWikiLinkText "cholangiocyte".
- Cholangiocyte code "TH H3.04.05.0.00011".
- Cholangiocyte latin "cholangiocytus".
- Cholangiocyte name "Cholangiocyte".
- Cholangiocyte wikiPageUsesTemplate Template:Infobox_anatomy.
- Cholangiocyte wikiPageUsesTemplate Template:Refimprove.
- Cholangiocyte wikiPageUsesTemplate Template:Reflist.
- Cholangiocyte subject Category:Digestive_system.
- Cholangiocyte subject Category:Epithelial_cells.
- Cholangiocyte subject Category:Human_cells.
- Cholangiocyte hypernym Cells.
- Cholangiocyte type AnatomicalStructure.
- Cholangiocyte type Cell.
- Cholangiocyte type Thing.
- Cholangiocyte type Q4936952.
- Cholangiocyte comment "Cholangiocytes are the epithelial cells of the bile duct. They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts.In the healthy liver, cholangiocytes contribute to bile secretion via net release of bicarbonate and water. Several hormones and locally acting mediators are known to contribute to cholangiocyte fluid/electrolyte secretion.".
- Cholangiocyte label "Cholangiocyte".
- Cholangiocyte sameAs Q5104283.
- Cholangiocyte sameAs m.07_jsr.
- Cholangiocyte sameAs Q5104283.
- Cholangiocyte wasDerivedFrom Cholangiocyte?oldid=609587613.
- Cholangiocyte isPrimaryTopicOf Cholangiocyte.
- Cholangiocyte name "Cholangiocyte".