Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Chlorotrianisene> ?p ?o }
- Chlorotrianisene abstract "Chlorotrianisene (CTA) (INN, USAN, BAN) (brand names Tace, Estregur, Anisene, Clorotrisin, Merbentyl, Triagen, many others), also known as tri-p-anisylchloroethylene (TACE) or as tris(p-methoxyphenyl)chloroethylene, is a synthetic, non-steroidal estrogen of the triphenylethylene group that was formerly used for the treatment of menopausal symptoms, estrogen deficiency, and prostate cancer before being discontinued. It was approved in the United States as TACE in 1952, and was introduced throughout Europe subsequently. CTA was the first estrogenic compound of the triphenylethylene series to be introduced.CTA was derived from estrobin (DBE), a derivative of the very weakly estrogenic compound triphenylethylene (TPE), which in turn was derived from structural modification of diethylstilbestrol (DES). CTA is a relatively weak estrogen, with about one-eighth the potency of DES. However, it is highly lipophilic and is stored in fat tissue for prolonged periods of time, with its slow release from fat resulting in a very long duration of action. CTA itself is inactive; it behaves as a prodrug to a weak estrogen that is formed as a metabolite via degradation of CTA in the liver. As such, the potency of CTA is reduced if it is given parenterally instead of orally.Although it is referred to as a weak estrogen and was used solely as an estrogen in clinical practice, CTA is actually a partial agonist of the estrogen receptor. As such, it is a selective estrogen receptor modulator (SERM), with predominantly estrogenic but also antiestrogenic effects, and was arguably the first SERM to ever be introduced. CTA can antagonize estradiol at the level of the hypothalamus, resulting in a disinhibition of the hypothalamic-pituitary-gonadal axis and an increase in estrogen levels. Clomifene and tamoxifen were both derived from CTA via structural modification, and are much weaker partial agonists than CTA and hence much more antiestrogenic in comparison. As an example, chlorotrianisene produces gynecomastia in men, albeit reportedly to a lesser extent than other estrogens, while clomifene and tamoxifen do not and can actually be used to treat gynecomastia.".
- Chlorotrianisene atcPrefix "G03".
- Chlorotrianisene atcSuffix "CA06".
- Chlorotrianisene casNumber "569-57-3".
- Chlorotrianisene chEBI "3641".
- Chlorotrianisene drugbank "DB00269".
- Chlorotrianisene fdaUniiCode "6V5034L121".
- Chlorotrianisene iupacName "1,1',1-(2-chloroethene-1,1,2-triyl)tris(4-methoxybenzene); 11-chloro-4,13-dimethoxy-12-(p''-methoxyphenyl)stilbene".
- Chlorotrianisene pubchem "11289".
- Chlorotrianisene thumbnail Chlorotrianisene.svg?width=300.
- Chlorotrianisene wikiPageID "6662470".
- Chlorotrianisene wikiPageLength "8836".
- Chlorotrianisene wikiPageOutDegree "42".
- Chlorotrianisene wikiPageRevisionID "698851395".
- Chlorotrianisene wikiPageWikiLink Adipose_tissue.
- Chlorotrianisene wikiPageWikiLink Antiestrogen.
- Chlorotrianisene wikiPageWikiLink British_Approved_Name.
- Chlorotrianisene wikiPageWikiLink Broparestrol.
- Chlorotrianisene wikiPageWikiLink Category:Organochlorides.
- Chlorotrianisene wikiPageWikiLink Category:Phenol_ethers.
- Chlorotrianisene wikiPageWikiLink Category:Prodrugs.
- Chlorotrianisene wikiPageWikiLink Category:Selective_estrogen_receptor_modulators.
- Chlorotrianisene wikiPageWikiLink Category:Synthetic_estrogens.
- Chlorotrianisene wikiPageWikiLink Clomifene.
- Chlorotrianisene wikiPageWikiLink Derivative_(chemistry).
- Chlorotrianisene wikiPageWikiLink Diethylstilbestrol.
- Chlorotrianisene wikiPageWikiLink Estradiol.
- Chlorotrianisene wikiPageWikiLink Estrobin.
- Chlorotrianisene wikiPageWikiLink Estrogen.
- Chlorotrianisene wikiPageWikiLink Estrogen_receptor.
- Chlorotrianisene wikiPageWikiLink Ethamoxytriphetol.
- Chlorotrianisene wikiPageWikiLink Europe.
- Chlorotrianisene wikiPageWikiLink Gynecomastia.
- Chlorotrianisene wikiPageWikiLink Hypoestrogenism.
- Chlorotrianisene wikiPageWikiLink Hypothalamic–pituitary–gonadal_axis.
- Chlorotrianisene wikiPageWikiLink Hypothalamus.
- Chlorotrianisene wikiPageWikiLink International_nonproprietary_name.
- Chlorotrianisene wikiPageWikiLink Lipophilicity.
- Chlorotrianisene wikiPageWikiLink Liver.
- Chlorotrianisene wikiPageWikiLink Menopause.
- Chlorotrianisene wikiPageWikiLink Metabolite.
- Chlorotrianisene wikiPageWikiLink Methallenestril.
- Chlorotrianisene wikiPageWikiLink Nonsteroidal.
- Chlorotrianisene wikiPageWikiLink Oral_administration.
- Chlorotrianisene wikiPageWikiLink Organic_compound.
- Chlorotrianisene wikiPageWikiLink Partial_agonist.
- Chlorotrianisene wikiPageWikiLink Prodrug.
- Chlorotrianisene wikiPageWikiLink Prostate_cancer.
- Chlorotrianisene wikiPageWikiLink Route_of_administration.
- Chlorotrianisene wikiPageWikiLink Selective_estrogen_receptor_modulator.
- Chlorotrianisene wikiPageWikiLink Stilbestrol.
- Chlorotrianisene wikiPageWikiLink Tamoxifen.
- Chlorotrianisene wikiPageWikiLink Triphenylethylene.
- Chlorotrianisene wikiPageWikiLink United_States.
- Chlorotrianisene wikiPageWikiLink United_States_Adopted_Name.
- Chlorotrianisene wikiPageWikiLinkText "Chlorotrianisene".
- Chlorotrianisene wikiPageWikiLinkText "chlorotrianisene".
- Chlorotrianisene atcPrefix "G03".
- Chlorotrianisene atcSuffix "CA06".
- Chlorotrianisene c "23".
- Chlorotrianisene casNumber "569".
- Chlorotrianisene chebi "3641".
- Chlorotrianisene chembl "1200761".
- Chlorotrianisene chemspiderid "10815".
- Chlorotrianisene cl "1".
- Chlorotrianisene drugbank "DB00269".
- Chlorotrianisene h "21".
- Chlorotrianisene inchi "1".
- Chlorotrianisene inchikey "BFPSDSIWYFKGBC-UHFFFAOYAB".
- Chlorotrianisene iupacName "660.0".
- Chlorotrianisene iupharLigand "7146".
- Chlorotrianisene kegg "D00269".
- Chlorotrianisene legalStatus "Discontinued".
- Chlorotrianisene molecularWeight "380.864".
- Chlorotrianisene o "3".
- Chlorotrianisene pregnancyUs "X".
- Chlorotrianisene proteinBound "50".
- Chlorotrianisene pubchem "11289".
- Chlorotrianisene routesOfAdministration Oral_administration.
- Chlorotrianisene smiles "Cl/C=Cc3ccccc3".
- Chlorotrianisene stdinchi "1".
- Chlorotrianisene stdinchikey "BFPSDSIWYFKGBC-UHFFFAOYSA-N".
- Chlorotrianisene synonyms "NSC-10108".
- Chlorotrianisene tradename "Tace".
- Chlorotrianisene unii "6".
- Chlorotrianisene verifiedfields "changed".
- Chlorotrianisene verifiedrevid "460033186".
- Chlorotrianisene watchedfields "changed".
- Chlorotrianisene wikiPageUsesTemplate Template:Cascite.
- Chlorotrianisene wikiPageUsesTemplate Template:Chemspidercite.
- Chlorotrianisene wikiPageUsesTemplate Template:Drugbankcite.
- Chlorotrianisene wikiPageUsesTemplate Template:Drugbox.
- Chlorotrianisene wikiPageUsesTemplate Template:Drugs.com.
- Chlorotrianisene wikiPageUsesTemplate Template:Ebicite.
- Chlorotrianisene wikiPageUsesTemplate Template:Estrogenics.
- Chlorotrianisene wikiPageUsesTemplate Template:Estrogens.
- Chlorotrianisene wikiPageUsesTemplate Template:Fdacite.
- Chlorotrianisene wikiPageUsesTemplate Template:Genito-urinary-drug-stub.
- Chlorotrianisene wikiPageUsesTemplate Template:Keggcite.
- Chlorotrianisene wikiPageUsesTemplate Template:Reflist.