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- Chloramphenicol_acetyltransferase abstract "Chloramphenicol acetyltransferase (or CAT) is a bacterial enzyme (EC 2.3.1.28) that detoxifies the antibiotic chloramphenicol and is responsible for chloramphenicol resistance in bacteria. This enzyme covalently attaches an acetyl group from acetyl-CoA to chloramphenicol, which prevents chloramphenicol from binding to ribosomes. A histidine residue, located in the C-terminal section of the enzyme, plays a central role in its catalytic mechanism.The crystal structure of the type III enzyme from Escherichia coli with chloramphenicol bound has been determined. CAT is a trimer of identical subunits (monomer Mr 25,000) and the trimeric structure is stabilised by a number of hydrogen bonds, some of which result in the extension of a beta-sheet across the subunit interface. Chloramphenicol binds in a deep pocket located at the boundary between adjacent subunits of the trimer, such that the majority of residues forming the binding pocket belong to one subunit while the catalytically essential histidine belongs to the adjacent subunit. His195 is appropriately positioned to act as a general base catalyst in the reaction, and the required tautomeric stabilisation is provided by an unusual interaction with a main-chain carbonyl oxygen.".
- Chloramphenicol_acetyltransferase symbol "CAT".
- Chloramphenicol_acetyltransferase thumbnail Chloramphenicol_acetyltransferase_3CLA_transparent.png?width=300.
- Chloramphenicol_acetyltransferase wikiPageID "2440667".
- Chloramphenicol_acetyltransferase wikiPageLength "4087".
- Chloramphenicol_acetyltransferase wikiPageOutDegree "12".
- Chloramphenicol_acetyltransferase wikiPageRevisionID "699057248".
- Chloramphenicol_acetyltransferase wikiPageWikiLink Acetyl.
- Chloramphenicol_acetyltransferase wikiPageWikiLink Acetyl-CoA.
- Chloramphenicol_acetyltransferase wikiPageWikiLink Antibiotics.
- Chloramphenicol_acetyltransferase wikiPageWikiLink Bacteria.
- Chloramphenicol_acetyltransferase wikiPageWikiLink Category:Bacterial_enzymes.
- Chloramphenicol_acetyltransferase wikiPageWikiLink Category:EC_2.3.1.
- Chloramphenicol_acetyltransferase wikiPageWikiLink Chloramphenicol.
- Chloramphenicol_acetyltransferase wikiPageWikiLink Enzyme.
- Chloramphenicol_acetyltransferase wikiPageWikiLink Escherichia_coli.
- Chloramphenicol_acetyltransferase wikiPageWikiLink Protein_trimer.
- Chloramphenicol_acetyltransferase wikiPageWikiLink Ribosome.
- Chloramphenicol_acetyltransferase wikiPageWikiLink Thin-layer_chromatography.
- Chloramphenicol_acetyltransferase wikiPageWikiLinkText "CAT assay".
- Chloramphenicol_acetyltransferase wikiPageWikiLinkText "Chloramphenicol acetyltransferase".
- Chloramphenicol_acetyltransferase wikiPageWikiLinkText "chloramphenicol acetyltransferase".
- Chloramphenicol_acetyltransferase caption "Ribbon diagram of the chloramphenicol acetyltransferase trimer with chloramphenicol bound. From .".
- Chloramphenicol_acetyltransferase casNumber "9040-07-07".
- Chloramphenicol_acetyltransferase ecNumber "2.3".
- Chloramphenicol_acetyltransferase goCode "16740".
- Chloramphenicol_acetyltransferase interpro "IPR001707".
- Chloramphenicol_acetyltransferase name "Chloramphenicol acetyltransferase".
- Chloramphenicol_acetyltransferase pdb "G:6-209 A:6-209 B:6-209 :1-205 :1-205 :1-205 :1-205 :1-205 :1-205".
- Chloramphenicol_acetyltransferase pfam "PF00302".
- Chloramphenicol_acetyltransferase prosite "PDOC00093".
- Chloramphenicol_acetyltransferase scop "3".
- Chloramphenicol_acetyltransferase symbol "CAT".
- Chloramphenicol_acetyltransferase wikiPageUsesTemplate Template:Acyltransferases.
- Chloramphenicol_acetyltransferase wikiPageUsesTemplate Template:EC_number.
- Chloramphenicol_acetyltransferase wikiPageUsesTemplate Template:Enzyme.
- Chloramphenicol_acetyltransferase wikiPageUsesTemplate Template:Enzymes.
- Chloramphenicol_acetyltransferase wikiPageUsesTemplate Template:InterPro_content.
- Chloramphenicol_acetyltransferase wikiPageUsesTemplate Template:PDB.
- Chloramphenicol_acetyltransferase wikiPageUsesTemplate Template:PDB3.
- Chloramphenicol_acetyltransferase wikiPageUsesTemplate Template:Pfam_box.
- Chloramphenicol_acetyltransferase wikiPageUsesTemplate Template:Portal_bar.
- Chloramphenicol_acetyltransferase wikiPageUsesTemplate Template:Reflist.
- Chloramphenicol_acetyltransferase subject Category:Bacterial_enzymes.
- Chloramphenicol_acetyltransferase subject Category:EC_2.3.1.
- Chloramphenicol_acetyltransferase hypernym Enzyme.
- Chloramphenicol_acetyltransferase type Biomolecule.
- Chloramphenicol_acetyltransferase type Protein.
- Chloramphenicol_acetyltransferase type Chemical.
- Chloramphenicol_acetyltransferase type Thing.
- Chloramphenicol_acetyltransferase type Q206229.
- Chloramphenicol_acetyltransferase type Q8054.
- Chloramphenicol_acetyltransferase comment "Chloramphenicol acetyltransferase (or CAT) is a bacterial enzyme (EC 2.3.1.28) that detoxifies the antibiotic chloramphenicol and is responsible for chloramphenicol resistance in bacteria. This enzyme covalently attaches an acetyl group from acetyl-CoA to chloramphenicol, which prevents chloramphenicol from binding to ribosomes.".
- Chloramphenicol_acetyltransferase label "Chloramphenicol acetyltransferase".
- Chloramphenicol_acetyltransferase sameAs Q2964079.
- Chloramphenicol_acetyltransferase sameAs Chloramphenicol-Acetyltransferase.
- Chloramphenicol_acetyltransferase sameAs Chloramphénicol_acétyltransférase.
- Chloramphenicol_acetyltransferase sameAs Cloramfenicolo_O-acetiltransferasi.
- Chloramphenicol_acetyltransferase sameAs m.07d6hk.
- Chloramphenicol_acetyltransferase sameAs Hloramfenikol_O-acetiltransferaza.
- Chloramphenicol_acetyltransferase sameAs Hloramfenikol_O-acetiltransferaza.
- Chloramphenicol_acetyltransferase sameAs Q2964079.
- Chloramphenicol_acetyltransferase wasDerivedFrom Chloramphenicol_acetyltransferase?oldid=699057248.
- Chloramphenicol_acetyltransferase depiction Chloramphenicol_acetyltransferase_3CLA_transparent.png.
- Chloramphenicol_acetyltransferase isPrimaryTopicOf Chloramphenicol_acetyltransferase.