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- Chemotherapy-induced_peripheral_neuropathy abstract "Chemotherapy-induced peripheral neuropathy (CIPN) is a progressive, enduring, and often irreversible condition featuring pain, numbness, tingling and sensitivity to cold in the hands and feet (sometimes progressing to the arms and legs) that afflicts between 30% and 40% of patients undergoing chemotherapy. Chemotherapy drugs associated with CIPN include thalidomide, the epothilones such as ixabepilone, the vinca alkaloids vincristine and vinblastine, the taxanes paclitaxel and docetaxel, the proteasome inhibitors such as bortezomib, and the platinum-based drugs cisplatin, oxaliplatin and carboplatin. Whether CIPN arises, and to what degree, is determined by the choice of drug, duration of use, the total amount consumed and whether the patient already has peripheral neuropathy. Though the symptoms are mainly sensory – pain, tingling, numbness and temperature sensitivity – in some cases motor nerves are affected, and occasionally, also, the autonomic nervous system.CIPN often follows the first chemotherapy dose and increases in severity as treatment continues, but this progression usually levels off at completion of treatment. The platinum-based drugs are the exception; with these drugs, sensation may continue to deteriorate for several months after the end of treatment. Some CIPN appears to be irreversible. Pain can often be helped with drug or other treatment but the numbness is usually resistant to treatment.CIPN disrupts leisure, work and family relations, and the pain of CIPN is often accompanied by sleep and mood disturbance, fatigue and functional difficulties. A 2007 American study found that most patients did not recall being told to expect CIPN, and doctors monitoring the condition rarely asked how it affects daily living but focused on practical effects such as dexterity and gait. It is not known what causes the condition, but microtubule and mitochondrial damage, and leaky blood vessels near nerve cells are some of the possibilities being explored.".
- Chemotherapy-induced_peripheral_neuropathy wikiPageID "32843140".
- Chemotherapy-induced_peripheral_neuropathy wikiPageLength "11031".
- Chemotherapy-induced_peripheral_neuropathy wikiPageOutDegree "59".
- Chemotherapy-induced_peripheral_neuropathy wikiPageRevisionID "705340417".
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLink Acetylcarnitine.
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLink Anticonvulsant.
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLink Antidepressant.
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLink Autonomic_nervous_system.
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLink Blind_experiment.
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLink Bortezomib.
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLink Calcium.
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLink Carboplatin.
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLink Category:Cancer.
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLink Category:Chemotherapy.
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLink Category:Peripheral_nervous_system_disorders.
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLink Chemotherapy.
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLink Cisplatin.
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLink Diabetic_neuropathy.
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLink Docetaxel.
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLink Duloxetine.
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLink Epothilone.
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLink Glutamine.
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLink Glutathione.
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLink Interleukin_6.
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLink Ixabepilone.
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLink Lipoic_acid.
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLink Magnesium.
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLink Microtubule.
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLink Mitochondrion.
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLink Motor_nerve.
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLink N-acetyl_cysteineas.
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLink National_Cancer_Institute.
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLink Omega-3_fatty_acid.
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLink Oxaliplatin.
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLink Paclitaxel.
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLink Phases_of_clinical_research.
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLink Placebo.
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLink Placebo-controlled_study.
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLink Pre-clinical_development.
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLink Proteasome_inhibitor.
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLink Randomized_controlled_trial.
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLink Randomized_experiment.
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLink Systematic_review.
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLink Taxane.
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLink Thalidomide.
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLink Valproate.
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLink Venlafaxine.
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLink Vinblastine.
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLink Vinca_alkaloid.
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLink Vincristine.
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLink Vitamin_B6.
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLink Vitamin_E.
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLinkText "Chemotherapy-induced peripheral neuropathy".
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLinkText "Chemotherapy-induced_peripheral_neuropathy".
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLinkText "chemotherapy-induced neuropathy".
- Chemotherapy-induced_peripheral_neuropathy wikiPageWikiLinkText "chemotherapy-induced peripheral neuropathy".
- Chemotherapy-induced_peripheral_neuropathy wikiPageUsesTemplate Template:Reflist.
- Chemotherapy-induced_peripheral_neuropathy subject Category:Cancer.
- Chemotherapy-induced_peripheral_neuropathy subject Category:Chemotherapy.
- Chemotherapy-induced_peripheral_neuropathy subject Category:Peripheral_nervous_system_disorders.
- Chemotherapy-induced_peripheral_neuropathy comment "Chemotherapy-induced peripheral neuropathy (CIPN) is a progressive, enduring, and often irreversible condition featuring pain, numbness, tingling and sensitivity to cold in the hands and feet (sometimes progressing to the arms and legs) that afflicts between 30% and 40% of patients undergoing chemotherapy.".
- Chemotherapy-induced_peripheral_neuropathy label "Chemotherapy-induced peripheral neuropathy".
- Chemotherapy-induced_peripheral_neuropathy sameAs Q17153857.
- Chemotherapy-induced_peripheral_neuropathy sameAs m.0wxxrj1.
- Chemotherapy-induced_peripheral_neuropathy sameAs Q17153857.
- Chemotherapy-induced_peripheral_neuropathy wasDerivedFrom Chemotherapy-induced_peripheral_neuropathy?oldid=705340417.
- Chemotherapy-induced_peripheral_neuropathy isPrimaryTopicOf Chemotherapy-induced_peripheral_neuropathy.