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- Cellular_cardiomyoplasty abstract "Death rates due to heart failure continue to rise steadily in the western world despite better strategies designed to salvage damaged or dying myocardium after myocardial infarction. In the United States alone, it is estimated that 5 million people have congestive heart failure presently and 500,000 more are diagnosed each year. The most prominent cause of myocardial infarction (MI) and subsequent myocardial cell death is undiagnosed coronary artery disease resulting in plaque rupture or dislodgement and myocardial cell ischemia. After an MI, myocardial cells that die or are damaged are replaced by collagen and fibroblasts in a healing process that remodels the heart, most typically the left ventricle. This tissue is non-functioning scar tissue and often leads to a permanent decrease in the efficiency of the myocardium.Cellular cardiomyoplasty, or cell-based cardiac repair, is a new potential therapeutic modality in which progenitor cells are used to repair regions of damaged or necrotic myocardium. The ability of transplanted progenitor cells to improve function within the failing heart has been shown in experimental animal models and in some human clinical trials. In November 2011, a large group of collaborators at Minneapolis Heart Institute Foundation at Abbott Northwestern found no significant difference in left ventricular ejection fraction (LVEF) or other markers, between a group of patients treated with cellular cardiomyoplasty and a group of control patients. In this study, all patients were post MI, post percutaneous coronary intervention (PCI) and that infusion of progenitor cells occurred 2–3 weeks after intervention. In a study that is currently underway (February 2012), however, more positive results were being reported: In the SCIPIO trial, patients treated with autologous cardiac stem cells post MI have been reported to be showing statistically significant increases in LVEF and reduction in infarct size over the control group at four months after implant. Positive results at the one-year mark are even more pronounced.Yet the SCIPIO trial \"was recently called into question\". Harvard University is \"now investigating the integrity of some of the data\". The Lancet recently published an non-specific ‘Expression of concern’ about the paper.Subsequently another preclinical study also raised doubts on the rational behind using this special kind of cells, as it was found that the special cells only have a minimal ability in generating new cardiomyocytes. Some specialists therefore now raise concerns to continue.".
- Cellular_cardiomyoplasty wikiPageID "31535716".
- Cellular_cardiomyoplasty wikiPageLength "15032".
- Cellular_cardiomyoplasty wikiPageOutDegree "27".
- Cellular_cardiomyoplasty wikiPageRevisionID "706188297".
- Cellular_cardiomyoplasty wikiPageWikiLink Adult_stem_cell.
- Cellular_cardiomyoplasty wikiPageWikiLink Autotransplantation.
- Cellular_cardiomyoplasty wikiPageWikiLink Cardiac_muscle.
- Cellular_cardiomyoplasty wikiPageWikiLink Category:Cardiac_procedures.
- Cellular_cardiomyoplasty wikiPageWikiLink Category:Regenerative_biomedicine.
- Cellular_cardiomyoplasty wikiPageWikiLink Cellular_differentiation.
- Cellular_cardiomyoplasty wikiPageWikiLink Collagen.
- Cellular_cardiomyoplasty wikiPageWikiLink Coronary_artery_disease.
- Cellular_cardiomyoplasty wikiPageWikiLink Cytokine.
- Cellular_cardiomyoplasty wikiPageWikiLink DNA.
- Cellular_cardiomyoplasty wikiPageWikiLink Ejection_fraction.
- Cellular_cardiomyoplasty wikiPageWikiLink Endothelium.
- Cellular_cardiomyoplasty wikiPageWikiLink Fibroblast.
- Cellular_cardiomyoplasty wikiPageWikiLink Growth_factor.
- Cellular_cardiomyoplasty wikiPageWikiLink Heart_failure.
- Cellular_cardiomyoplasty wikiPageWikiLink Homogeneity_and_heterogeneity.
- Cellular_cardiomyoplasty wikiPageWikiLink Immunogenicity.
- Cellular_cardiomyoplasty wikiPageWikiLink Ischemia.
- Cellular_cardiomyoplasty wikiPageWikiLink Myocardial_infarction.
- Cellular_cardiomyoplasty wikiPageWikiLink Myocyte.
- Cellular_cardiomyoplasty wikiPageWikiLink Notch_signaling_pathway.
- Cellular_cardiomyoplasty wikiPageWikiLink Percutaneous_coronary_intervention.
- Cellular_cardiomyoplasty wikiPageWikiLink Progenitor_cell.
- Cellular_cardiomyoplasty wikiPageWikiLink Somatic_cell.
- Cellular_cardiomyoplasty wikiPageWikiLink Teratology.
- Cellular_cardiomyoplasty wikiPageWikiLink Teratoma.
- Cellular_cardiomyoplasty wikiPageWikiLink Transcription_factor.
- Cellular_cardiomyoplasty wikiPageUsesTemplate Template:Citation_needed.
- Cellular_cardiomyoplasty wikiPageUsesTemplate Template:Clarify.
- Cellular_cardiomyoplasty wikiPageUsesTemplate Template:Orphan.
- Cellular_cardiomyoplasty wikiPageUsesTemplate Template:Reflist.
- Cellular_cardiomyoplasty subject Category:Cardiac_procedures.
- Cellular_cardiomyoplasty subject Category:Regenerative_biomedicine.
- Cellular_cardiomyoplasty comment "Death rates due to heart failure continue to rise steadily in the western world despite better strategies designed to salvage damaged or dying myocardium after myocardial infarction. In the United States alone, it is estimated that 5 million people have congestive heart failure presently and 500,000 more are diagnosed each year.".
- Cellular_cardiomyoplasty label "Cellular cardiomyoplasty".
- Cellular_cardiomyoplasty sameAs Q5058353.
- Cellular_cardiomyoplasty sameAs m.0glsf20.
- Cellular_cardiomyoplasty sameAs Q5058353.
- Cellular_cardiomyoplasty wasDerivedFrom Cellular_cardiomyoplasty?oldid=706188297.
- Cellular_cardiomyoplasty isPrimaryTopicOf Cellular_cardiomyoplasty.