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- Caroverine abstract "Caroverine (Spasmium, Spadon, Tinnex) is a drug used in Tinnitus treatment improves mechanosensitivity and mechanotransduction phenomenon and otoneuroprotective (inner ear protective) agent in some countries. It acts as an N-type calcium channel blocker, competitive AMPA receptor antagonist, and non-competitive NMDA receptor antagonist. It also has potent antioxidant effects.Caroverine [1-(diethylaminoethyl) -3 – (p-methoxybenzyl) – 1, 2 – hydroquinoxaline-2-one] is a quinoxaline derivative developed in the 1960s. Caroverine, an N-methyl-D-aspartate and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist together with antioxidant activity, has been shown to protect the inner ear from excitotoxicity and to be effective in the treatment of tinnitus, sudden hearing loss and speech discrimination disorders in presbyacusis.In recent years, it is on grounds of its quinoxline-dione structure, glutamate antagonism of him excitatory, afferent synapses of the cochlear inner hair cells and its neuroprotective properties that caroverine has been investigated as a new drug in the pharmacological treatment of tinnitus.Caroverine also acts as a reversible glutamate antagonist in afferent cochlear synapse. Theoretical justification for the introduction of caroverine in the pharmacotherapy of tinnitus is that glutamate, as a key neurotransmitter in the central nervous system, is the most likely transmitter-substance in the afferent cochlear synapse (Ehrenberger-K eta al., 1992; Ehrenberger-K et al., 1995a; Ehrenberger-K et al., 1995b).".
- Caroverine atcPrefix "A03".
- Caroverine atcSuffix "AX11".
- Caroverine casNumber "23465-76-1".
- Caroverine fdaUniiCode "XJ73B0K6KB".
- Caroverine iupacName "1-[2-(diethylamino)ethyl]- 3-(4-methoxybenzyl)quinoxalin- 2(1H)-one".
- Caroverine pubchem "65709".
- Caroverine thumbnail Caroverine.png?width=300.
- Caroverine wikiPageID "20007643".
- Caroverine wikiPageLength "4551".
- Caroverine wikiPageOutDegree "16".
- Caroverine wikiPageRevisionID "707879490".
- Caroverine wikiPageWikiLink AMPA_receptor.
- Caroverine wikiPageWikiLink Antioxidant.
- Caroverine wikiPageWikiLink Calcium_channel_blocker.
- Caroverine wikiPageWikiLink Category:AMPA_receptor_antagonists.
- Caroverine wikiPageWikiLink Category:Lactams.
- Caroverine wikiPageWikiLink Category:NMDA_receptor_antagonists.
- Caroverine wikiPageWikiLink Category:Phenol_ethers.
- Caroverine wikiPageWikiLink Category:Quinoxalines.
- Caroverine wikiPageWikiLink Competitive_inhibition.
- Caroverine wikiPageWikiLink Drug.
- Caroverine wikiPageWikiLink Inner_ear.
- Caroverine wikiPageWikiLink N-type_calcium_channel.
- Caroverine wikiPageWikiLink NMDA_receptor_antagonist.
- Caroverine wikiPageWikiLink Neuroprotection.
- Caroverine wikiPageWikiLink Non-competitive_inhibition.
- Caroverine wikiPageWikiLink Quinoxalinedione.
- Caroverine wikiPageWikiLinkText "Caroverine".
- Caroverine wikiPageWikiLinkText "caroverine".
- Caroverine atcPrefix "A03".
- Caroverine atcSuffix "AX11".
- Caroverine c "22".
- Caroverine casNumber "23465".
- Caroverine chembl "1729803".
- Caroverine chemspiderid "59135".
- Caroverine h "27".
- Caroverine inchi "1".
- Caroverine inchikey "MSPRUJDUTKRMLM-UHFFFAOYAM".
- Caroverine iupacName "1".
- Caroverine legalStatus "Rx-only".
- Caroverine molecularWeight "365.47".
- Caroverine n "3".
- Caroverine o "2".
- Caroverine pubchem "65709".
- Caroverine routesOfAdministration "Oral".
- Caroverine smiles "O=C/1NCCNCC".
- Caroverine stdinchi "1".
- Caroverine stdinchikey "MSPRUJDUTKRMLM-UHFFFAOYSA-N".
- Caroverine unii "XJ73B0K6KB".
- Caroverine verifiedfields "changed".
- Caroverine verifiedrevid "455349170".
- Caroverine wikiPageUsesTemplate Template:Calcium_channel_blockers.
- Caroverine wikiPageUsesTemplate Template:Cascite.
- Caroverine wikiPageUsesTemplate Template:Chemspidercite.
- Caroverine wikiPageUsesTemplate Template:Drugbox.
- Caroverine wikiPageUsesTemplate Template:Ebicite.
- Caroverine wikiPageUsesTemplate Template:Fdacite.
- Caroverine wikiPageUsesTemplate Template:Glutamatergics.
- Caroverine wikiPageUsesTemplate Template:Muscle_relaxants.
- Caroverine wikiPageUsesTemplate Template:Reflist.
- Caroverine wikiPageUsesTemplate Template:Stdinchicite.
- Caroverine subject Category:AMPA_receptor_antagonists.
- Caroverine subject Category:Lactams.
- Caroverine subject Category:NMDA_receptor_antagonists.
- Caroverine subject Category:Phenol_ethers.
- Caroverine subject Category:Quinoxalines.
- Caroverine hypernym Drug.
- Caroverine type ChemicalSubstance.
- Caroverine type Drug.
- Caroverine type Amide.
- Caroverine type Drug.
- Caroverine type Ether.
- Caroverine type Heterocycle.
- Caroverine type Lactam.
- Caroverine type Redirect.
- Caroverine type ChemicalObject.
- Caroverine type Thing.
- Caroverine type Q8386.
- Caroverine comment "Caroverine (Spasmium, Spadon, Tinnex) is a drug used in Tinnitus treatment improves mechanosensitivity and mechanotransduction phenomenon and otoneuroprotective (inner ear protective) agent in some countries. It acts as an N-type calcium channel blocker, competitive AMPA receptor antagonist, and non-competitive NMDA receptor antagonist.".
- Caroverine label "Caroverine".
- Caroverine sameAs Q5045575.
- Caroverine sameAs m.04ybr0z.
- Caroverine sameAs Karoverin.
- Caroverine sameAs Karoverin.
- Caroverine sameAs Q5045575.
- Caroverine wasDerivedFrom Caroverine?oldid=707879490.
- Caroverine depiction Caroverine.png.
- Caroverine isPrimaryTopicOf Caroverine.