Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Cancer_systems_biology> ?p ?o }
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- Cancer_systems_biology abstract "Cancer systems biology encompasses the application of systems biology approaches to cancer research, in order to study the disease as a complex adaptive system with emerging properties at multiple biological scales. More explicitly, because cancer spans multiple biological, spatial and temporal scales, communication and feedback mechanisms across the scales create a highly complex dynamic system. The relationships between scales is not simple or necessarily direct, and sometimes become combinatorial, so that systems approaches are essential to evaluate these relationships quantitatively and qualitatively.Cancer systems biology therefore adopts a holistic view of cancer aimed at integrating its many biological scales, including genetics, signaling networks, epigenetics, cellular behavior, histology, (pre)clinical manifestations and epidemiology. Ultimately, cancer properties at one scale, e.g., histology, are explained by properties at a scale below, e.g., cell behavior. Likewise, a higher scale, e.g., epidemiology, can encroach on a lower scale, e.g., genetics. The fundamental concept is that percolation of properties across scales must be measured and taken into account in order to fully understand etiology, progression and dynamics of cancer. The systems biology approach relies heavily on the successes of decades of reductionism, which has clarified the component parts and mechanistic principles of living organisms, as well as their key alterations in cancer, especially at the genetic/genomic scale, to deep detail. Basic researchers and clinicians have progressively recognized the complexity of cancer and of its interaction with the micro- and macro-environment, since putting together the components to provide a cohesive view of the disease has been challenging and hampered progress. Cancer Systems Biology transcends the “reductionist” approach to cancer that typically produces causative explanations focused on a single gene or mutation, with little emphasis on inter-scale relationships.Cancer systems biology merges traditional basic and clinical cancer research with “exact” sciences, such as applied mathematics, engineering, and physics. It incorporates a spectrum of “omics” technologies (genomics, proteomics, epigenomics, etc.) and molecular imaging, to generate computational algorithms and quantitative models that shed light on mechanisms underlying the cancer process and predict response to intervention.".
- Cancer_systems_biology wikiPageID "39198919".
- Cancer_systems_biology wikiPageLength "9580".
- Cancer_systems_biology wikiPageOutDegree "27".
- Cancer_systems_biology wikiPageRevisionID "688037315".
- Cancer_systems_biology wikiPageWikiLink Adaptive_system.
- Cancer_systems_biology wikiPageWikiLink Bioconductor.
- Cancer_systems_biology wikiPageWikiLink Cancer.
- Cancer_systems_biology wikiPageWikiLink Category:Cancer.
- Cancer_systems_biology wikiPageWikiLink Category:Systems_biology.
- Cancer_systems_biology wikiPageWikiLink Cell_signaling.
- Cancer_systems_biology wikiPageWikiLink Combinatorics.
- Cancer_systems_biology wikiPageWikiLink Emergence.
- Cancer_systems_biology wikiPageWikiLink Engineering.
- Cancer_systems_biology wikiPageWikiLink Epidemiology.
- Cancer_systems_biology wikiPageWikiLink Epigenetics.
- Cancer_systems_biology wikiPageWikiLink Epigenomics.
- Cancer_systems_biology wikiPageWikiLink Etiology.
- Cancer_systems_biology wikiPageWikiLink Feedback.
- Cancer_systems_biology wikiPageWikiLink Genetics.
- Cancer_systems_biology wikiPageWikiLink Genomics.
- Cancer_systems_biology wikiPageWikiLink Holism.
- Cancer_systems_biology wikiPageWikiLink List_of_systems_biology_research_groups.
- Cancer_systems_biology wikiPageWikiLink Mathematics.
- Cancer_systems_biology wikiPageWikiLink Molecular_imaging.
- Cancer_systems_biology wikiPageWikiLink Physics.
- Cancer_systems_biology wikiPageWikiLink Proteomics.
- Cancer_systems_biology wikiPageWikiLink Reductionism.
- Cancer_systems_biology wikiPageWikiLink Systems_biology.
- Cancer_systems_biology wikiPageWikiLink The_Cancer_Genome_Atlas.
- Cancer_systems_biology wikiPageWikiLinkText "Cancer gene networks".
- Cancer_systems_biology wikiPageWikiLinkText "Cancer systems biology".
- Cancer_systems_biology wikiPageUsesTemplate Template:Essay-like.
- Cancer_systems_biology wikiPageUsesTemplate Template:Lead_rewrite.
- Cancer_systems_biology wikiPageUsesTemplate Template:Multiple_issues.
- Cancer_systems_biology wikiPageUsesTemplate Template:Notability.
- Cancer_systems_biology wikiPageUsesTemplate Template:Reflist.
- Cancer_systems_biology subject Category:Cancer.
- Cancer_systems_biology subject Category:Systems_biology.
- Cancer_systems_biology comment "Cancer systems biology encompasses the application of systems biology approaches to cancer research, in order to study the disease as a complex adaptive system with emerging properties at multiple biological scales. More explicitly, because cancer spans multiple biological, spatial and temporal scales, communication and feedback mechanisms across the scales create a highly complex dynamic system.".
- Cancer_systems_biology label "Cancer systems biology".
- Cancer_systems_biology sameAs Q16247115.
- Cancer_systems_biology sameAs m.0v3gvgd.
- Cancer_systems_biology sameAs Q16247115.
- Cancer_systems_biology wasDerivedFrom Cancer_systems_biology?oldid=688037315.
- Cancer_systems_biology isPrimaryTopicOf Cancer_systems_biology.