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- CX-546 abstract "CX-546 is an ampakine drug developed by Cortex Pharmaceuticals.It has been proposed as a treatment for schizophrenia. CX-546 was the second drug of note to come out of the Cortex research program, after CX-516, but while it was an improvement over its predecessor in some respects, it still has problems with limited oral bioavailability.However CX-546 still represented a significant advance that led on to the development of newer compounds such as CX-614 and CX-717 with superior properties over the earlier drugs. CX-546 itself has been investigated for other applications, and most notably has been found to show significant efficacy in reversing the respiratory depression produced by sedative drugs such as opioids and barbiturates.No effective respiratory stimulants are currently marketed for this application, with CX-546 being only the third drug discovered (after BIMU-8 and BW373U86) that effectively relieves the respiratory depression induced by fentanyl without reducing the analgesic effects. CX-546 could be developed for this purpose, although it is more likely Cortex will use newer and more potent analogues such as CX-1739 or CX-1763 which are likely to be more suitable for commercial development.[1]".
- CX-546 casNumber "215923-54-9".
- CX-546 fdaUniiCode "PV6YEC8983".
- CX-546 iupacName "2,3-dihydro-1,4-benzodioxin-7-yl-(1-piperidyl)methanone".
- CX-546 pubchem "2890".
- CX-546 thumbnail CX546.png?width=300.
- CX-546 wikiPageExternalLink 940011-26.html.
- CX-546 wikiPageID "13839587".
- CX-546 wikiPageLength "3692".
- CX-546 wikiPageOutDegree "18".
- CX-546 wikiPageRevisionID "705632138".
- CX-546 wikiPageWikiLink Ampakine.
- CX-546 wikiPageWikiLink BIMU8.
- CX-546 wikiPageWikiLink BW373U86.
- CX-546 wikiPageWikiLink Barbiturate.
- CX-546 wikiPageWikiLink CX-516.
- CX-546 wikiPageWikiLink CX614.
- CX-546 wikiPageWikiLink CX717.
- CX-546 wikiPageWikiLink Category:AMPA_receptor_agonists.
- CX-546 wikiPageWikiLink Category:Ampakines.
- CX-546 wikiPageWikiLink Category:Benzamides.
- CX-546 wikiPageWikiLink Category:Benzodioxins.
- CX-546 wikiPageWikiLink Category:Piperidines.
- CX-546 wikiPageWikiLink Category:Respiratory_agents.
- CX-546 wikiPageWikiLink Cortex_Pharmaceuticals.
- CX-546 wikiPageWikiLink Fentanyl.
- CX-546 wikiPageWikiLink Hypoventilation.
- CX-546 wikiPageWikiLink Opioid.
- CX-546 wikiPageWikiLink Schizophrenia.
- CX-546 wikiPageWikiLinkText "CX-546".
- CX-546 c "14".
- CX-546 casNumber "215923".
- CX-546 chemspiderid "2787".
- CX-546 h "17".
- CX-546 inchi "1".
- CX-546 inchikey "LJUNPHMOGNFFOS-UHFFFAOYAJ".
- CX-546 iupacName "23".
- CX-546 iupharLigand "4166".
- CX-546 legalStatus "Investigational New Medicine".
- CX-546 molecularWeight "247.28968".
- CX-546 n "1".
- CX-546 o "3".
- CX-546 pubchem "2890".
- CX-546 smiles "C1CCNCC2=CC3=COCCO3".
- CX-546 stdinchi "1".
- CX-546 stdinchikey "LJUNPHMOGNFFOS-UHFFFAOYSA-N".
- CX-546 synonyms "CX-546".
- CX-546 unii "PV6YEC8983".
- CX-546 verifiedrevid "443493909".
- CX-546 width "180".
- CX-546 wikiPageUsesTemplate Template:Cascite.
- CX-546 wikiPageUsesTemplate Template:Drugbankcite.
- CX-546 wikiPageUsesTemplate Template:Drugbox.
- CX-546 wikiPageUsesTemplate Template:Fdacite.
- CX-546 wikiPageUsesTemplate Template:Glutamatergics.
- CX-546 wikiPageUsesTemplate Template:Nervous-system-drug-stub.
- CX-546 wikiPageUsesTemplate Template:Nootropics.
- CX-546 wikiPageUsesTemplate Template:Other_respiratory_system_products.
- CX-546 wikiPageUsesTemplate Template:Respiratory-system-drug-stub.
- CX-546 subject Category:AMPA_receptor_agonists.
- CX-546 subject Category:Ampakines.
- CX-546 subject Category:Benzamides.
- CX-546 subject Category:Benzodioxins.
- CX-546 subject Category:Piperidines.
- CX-546 subject Category:Respiratory_agents.
- CX-546 hypernym Drug.
- CX-546 type ChemicalSubstance.
- CX-546 type Drug.
- CX-546 type Carboxamide.
- CX-546 type Chemical.
- CX-546 type Drug.
- CX-546 type Heterocycle.
- CX-546 type Modulator.
- CX-546 type Nootropic.
- CX-546 type Redirect.
- CX-546 type ChemicalObject.
- CX-546 type Thing.
- CX-546 type Q8386.
- CX-546 comment "CX-546 is an ampakine drug developed by Cortex Pharmaceuticals.It has been proposed as a treatment for schizophrenia.".
- CX-546 label "CX-546".
- CX-546 sameAs Q5014874.
- CX-546 sameAs CX-546.
- CX-546 sameAs m.03ckxln.
- CX-546 sameAs CX-546.
- CX-546 sameAs CX-546.
- CX-546 sameAs Q5014874.
- CX-546 wasDerivedFrom CX-546?oldid=705632138.
- CX-546 depiction CX546.png.
- CX-546 isPrimaryTopicOf CX-546.