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- CUL1 abstract "Cullin 1, also known as CUL1, is a human protein and gene from cullin family.This protein plays an important role in protein degradation and protein ubiquitination.This is an essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, it serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme.This protein is a part of a SCF complex consisting of CUL1, RBX1, SKP1 and SKP2. It also interacts with RNF7. Part of a complex with TIP120A/CAND1 and RBX1. The unneddylated form interacts with TIP120A/CAND1 and the interaction negatively regulates the association with SKP1 in the SCF complex. Interacts with COPS2.It is expressed in lung fibroblasts.The protein is neddylated, which enhances the ubiquitination activity of SCF. Deneddylated via its interaction with the COP9 signalosome (CSN) complex.".
- CUL1 entrezgene "8454".
- CUL1 wikiPageID "14143884".
- CUL1 wikiPageLength "8157".
- CUL1 wikiPageOutDegree "26".
- CUL1 wikiPageRevisionID "659860413".
- CUL1 wikiPageWikiLink 2003_United_Nations_Climate_Change_Conference.
- CUL1 wikiPageWikiLink CAND1.
- CUL1 wikiPageWikiLink COPS2.
- CUL1 wikiPageWikiLink Cell_cycle.
- CUL1 wikiPageWikiLink Cullin.
- CUL1 wikiPageWikiLink F-box_protein.
- CUL1 wikiPageWikiLink Fibroblast.
- CUL1 wikiPageWikiLink Gene.
- CUL1 wikiPageWikiLink Neddylation.
- CUL1 wikiPageWikiLink Proteolysis.
- CUL1 wikiPageWikiLink RBX1.
- CUL1 wikiPageWikiLink RNF7.
- CUL1 wikiPageWikiLink SCF_complex.
- CUL1 wikiPageWikiLink SKP2.
- CUL1 wikiPageWikiLink Signal_transduction.
- CUL1 wikiPageWikiLink Skp1.
- CUL1 wikiPageWikiLink TIP120A.
- CUL1 wikiPageWikiLink Transcription_(genetics).
- CUL1 wikiPageWikiLink Ubiquitin.
- CUL1 wikiPageWikiLink Ubiquitin-conjugating_enzyme.
- CUL1 wikiPageWikiLink Ubiquitin_ligase.
- CUL1 wikiPageWikiLinkText "CUL1".
- CUL1 requireManualInspection "no".
- CUL1 updateCitations "yes".
- CUL1 updatePage "yes".
- CUL1 updateProteinBox "yes".
- CUL1 updateSummary "yes".
- CUL1 wikiPageUsesTemplate Template:Cite_journal.
- CUL1 wikiPageUsesTemplate Template:Gene-7-stub.
- CUL1 wikiPageUsesTemplate Template:PBB.
- CUL1 wikiPageUsesTemplate Template:PBB_Controls.
- CUL1 wikiPageUsesTemplate Template:PBB_Further_reading.
- CUL1 wikiPageUsesTemplate Template:PBB_Summary.
- CUL1 wikiPageUsesTemplate Template:PDB_Gallery.
- CUL1 wikiPageUsesTemplate Template:Refbegin.
- CUL1 wikiPageUsesTemplate Template:Refend.
- CUL1 hypernym Protein.
- CUL1 type Biomolecule.
- CUL1 type Protein.
- CUL1 type Redirect.
- CUL1 type Thing.
- CUL1 type Q206229.
- CUL1 type Q8054.
- CUL1 comment "Cullin 1, also known as CUL1, is a human protein and gene from cullin family.This protein plays an important role in protein degradation and protein ubiquitination.This is an essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, it serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits.".
- CUL1 label "CUL1".
- CUL1 sameAs Q18032946.
- CUL1 sameAs m.03cvytn.
- CUL1 sameAs Куллин_1.
- CUL1 sameAs Q18032946.
- CUL1 wasDerivedFrom CUL1?oldid=659860413.
- CUL1 isPrimaryTopicOf CUL1.