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- CRYAA abstract "Alpha-crystallin A chain is a protein that in humans is encoded by the CRYAA gene.Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Defects in this gene cause autosomal dominant congenital cataract (ADCC).".
- CRYAA entrezgene "1409".
- CRYAA wikiPageID "15787372".
- CRYAA wikiPageLength "8740".
- CRYAA wikiPageOutDegree "7".
- CRYAA wikiPageRevisionID "659859795".
- CRYAA wikiPageWikiLink CRYAB.
- CRYAA wikiPageWikiLink CRYBB2.
- CRYAA wikiPageWikiLink CRYGC.
- CRYAA wikiPageWikiLink Gene.
- CRYAA wikiPageWikiLink Hsp27.
- CRYAA wikiPageWikiLink Protein.
- CRYAA wikiPageWikiLink Protein–protein_interaction.
- CRYAA wikiPageWikiLinkText "CRYAA".
- CRYAA requireManualInspection "no".
- CRYAA summaryText "Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Defects in this gene cause autosomal dominant congenital cataract .".
- CRYAA updateCitations "yes".
- CRYAA updatePage "yes".
- CRYAA updateProteinBox "yes".
- CRYAA updateSummary "yes".
- CRYAA wikiPageUsesTemplate Template:Cite_journal.
- CRYAA wikiPageUsesTemplate Template:Eye_proteins.
- CRYAA wikiPageUsesTemplate Template:Gene-21-stub.
- CRYAA wikiPageUsesTemplate Template:NLM_content.
- CRYAA wikiPageUsesTemplate Template:PBB.
- CRYAA wikiPageUsesTemplate Template:PBB_Controls.
- CRYAA wikiPageUsesTemplate Template:PBB_Further_reading.
- CRYAA wikiPageUsesTemplate Template:PBB_Summary.
- CRYAA wikiPageUsesTemplate Template:Refbegin.
- CRYAA wikiPageUsesTemplate Template:Refend.
- CRYAA wikiPageUsesTemplate Template:Reflist.
- CRYAA hypernym Protein.
- CRYAA type Biomolecule.
- CRYAA type Protein.
- CRYAA type Institute.
- CRYAA type Source.
- CRYAA type Thing.
- CRYAA type Q206229.
- CRYAA type Q8054.
- CRYAA comment "Alpha-crystallin A chain is a protein that in humans is encoded by the CRYAA gene.Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins.".
- CRYAA label "CRYAA".
- CRYAA sameAs Q17909993.
- CRYAA sameAs CRYAA.
- CRYAA sameAs m.03ntq0c.
- CRYAA sameAs Q17909993.
- CRYAA wasDerivedFrom CRYAA?oldid=659859795.
- CRYAA isPrimaryTopicOf CRYAA.