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- CRM_domain abstract "In molecular biology, the CRM domain is an approximately 100-amino acid RNA-binding domain. The name CRM (chloroplast RNA splicing and ribosome maturation) has been suggested to reflect the functions established for four characterised members of the family: Zea mays (Maize) CRS1, CAF1 and CAF2 proteins and the Escherichia coli protein YhbY. Proteins containing the CRM domain are found in eubacteria, archaea, and plants. The CRM domain is represented as a stand-alone protein in archaea and bacteria, and in single- and multi-domain proteins in plants. It has been suggested that prokaryotic CRM proteins existed as ribosome-associated proteins prior to the divergence of archaea and bacteria, and that they were co-opted in the plant lineage as RNA binding modules by incorporation into diverse protein contexts. Plant CRM domains are predicted to reside not only in the chloroplast, but also in the mitochondrion and the nucleo/cytoplasmic compartment. The diversity of the CRM domain family in plants suggests a diverse set of RNA targets.The CRM domain is a compact alpha/beta domain consisting of a four-stranded beta sheet and three alpha helices with an alpha-beta-alpha-beta-alpha-beta-beta topology. The beta sheet face is basic, consistent with a role in RNA binding. Proximal to the basic beta sheet face is another moiety that could contribute to nucleic acid recognition. Connecting strand beta1 and helix alpha2 is a loop with a six amino acid motif, GxxG flanked by large aliphatic residues, within which one 'x' is typically a basic residue.Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly. GFP fused to a single-domain CRM protein from maize localises to the nucleolus, suggesting that an analogous activity may have been retained in plants. A CRM domain containing protein in plant chloroplasts has been shown to function in group I and II intron splicing. In vitro experiments with an isolated maize CRM domain have shown it to have RNA binding activity. These and other results suggest that the CRM domain evolved in the context of ribosome function prior to the divergence of Archaea and Bacteria, that this function has been maintained in extant prokaryotes, and that the domain was recruited to serve as an RNA binding module during the evolution of plant genomes. YhbY has a fold similar to that of the C-terminal domain of translation initiation factor 3 (IF3C), which binds to 16S rRNA in the 30S ribosome.".
- CRM_domain symbol "CRS1_YhbY".
- CRM_domain thumbnail PDB_1rq8_EBI.jpg?width=300.
- CRM_domain wikiPageID "32462783".
- CRM_domain wikiPageLength "5411".
- CRM_domain wikiPageOutDegree "44".
- CRM_domain wikiPageRevisionID "593876599".
- CRM_domain wikiPageWikiLink Aliphatic_compound.
- CRM_domain wikiPageWikiLink Alpha_helix.
- CRM_domain wikiPageWikiLink Amino_acid.
- CRM_domain wikiPageWikiLink Archaea.
- CRM_domain wikiPageWikiLink Bacteria.
- CRM_domain wikiPageWikiLink Base_(chemistry).
- CRM_domain wikiPageWikiLink Beta_sheet.
- CRM_domain wikiPageWikiLink Category:Protein_domains.
- CRM_domain wikiPageWikiLink Chloroplast.
- CRM_domain wikiPageWikiLink Escherichia_coli.
- CRM_domain wikiPageWikiLink Eukaryotic_initiation_factor.
- CRM_domain wikiPageWikiLink Evolution.
- CRM_domain wikiPageWikiLink Genome.
- CRM_domain wikiPageWikiLink Green_fluorescent_protein.
- CRM_domain wikiPageWikiLink Helix.
- CRM_domain wikiPageWikiLink In_vitro.
- CRM_domain wikiPageWikiLink Intron.
- CRM_domain wikiPageWikiLink Maize.
- CRM_domain wikiPageWikiLink Mitochondrion.
- CRM_domain wikiPageWikiLink Molecular_binding.
- CRM_domain wikiPageWikiLink Nucleic_acid.
- CRM_domain wikiPageWikiLink Nucleolus.
- CRM_domain wikiPageWikiLink Plant.
- CRM_domain wikiPageWikiLink Prokaryote.
- CRM_domain wikiPageWikiLink Protein.
- CRM_domain wikiPageWikiLink Protein_domain.
- CRM_domain wikiPageWikiLink Protein_folding.
- CRM_domain wikiPageWikiLink RNA.
- CRM_domain wikiPageWikiLink RNA_splicing.
- CRM_domain wikiPageWikiLink Residue_(chemistry).
- CRM_domain wikiPageWikiLink Ribosome.
- CRM_domain wikiPageWikiLink Translation_(biology).
- CRM_domain wikiPageWikiLink Turn_(biochemistry).
- CRM_domain caption "solution structure of the hypothetical protein sav1595 from staphylococcus aureus, a putative rna binding protein".
- CRM_domain interpro "IPR001890".
- CRM_domain name "CRS1_YhbY".
- CRM_domain pfam "PF01985".
- CRM_domain prosite "PDOC01005".
- CRM_domain scop "1".
- CRM_domain symbol "CRS1_YhbY".
- CRM_domain wikiPageUsesTemplate Template:Infobox_protein_family.
- CRM_domain wikiPageUsesTemplate Template:InterPro_content.
- CRM_domain wikiPageUsesTemplate Template:Orphan.
- CRM_domain wikiPageUsesTemplate Template:Reflist.
- CRM_domain subject Category:Protein_domains.
- CRM_domain type Biomolecule.
- CRM_domain type Protein.
- CRM_domain type Chemical.
- CRM_domain type Domain.
- CRM_domain type Thing.
- CRM_domain type Q206229.
- CRM_domain type Q8054.
- CRM_domain comment "In molecular biology, the CRM domain is an approximately 100-amino acid RNA-binding domain. The name CRM (chloroplast RNA splicing and ribosome maturation) has been suggested to reflect the functions established for four characterised members of the family: Zea mays (Maize) CRS1, CAF1 and CAF2 proteins and the Escherichia coli protein YhbY. Proteins containing the CRM domain are found in eubacteria, archaea, and plants.".
- CRM_domain label "CRM domain".
- CRM_domain sameAs Q5013917.
- CRM_domain sameAs m.0h1gk4v.
- CRM_domain sameAs Q5013917.
- CRM_domain wasDerivedFrom CRM_domain?oldid=593876599.
- CRM_domain depiction PDB_1rq8_EBI.jpg.
- CRM_domain isPrimaryTopicOf CRM_domain.