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- CLDN16 abstract "Claudin-16 is a protein that in humans is encoded by the CLDN16 gene. It belongs to the group of claudins.Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are composed of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is found primarily in the kidneys, specifically in the thick ascending limb of Henle, where it acts as either an intercellular pore or ion concentration sensor to regulate the paracellular resorption of magnesium ions. Defects in this gene are a cause of primary hypomagnesemia, which is characterized by massive renal magnesium wasting with hypomagnesemia and hypercalciuria, resulting in nephrocalcinosis and renal failure.".
- CLDN16 entrezgene "10686".
- CLDN16 wikiPageID "14820064".
- CLDN16 wikiPageLength "13362".
- CLDN16 wikiPageOutDegree "28".
- CLDN16 wikiPageRevisionID "697166775".
- CLDN16 wikiPageWikiLink Auditory_brainstem_response.
- CLDN16 wikiPageWikiLink Category:Genes_mutated_in_mice.
- CLDN16 wikiPageWikiLink Citrobacter.
- CLDN16 wikiPageWikiLink Claudin.
- CLDN16 wikiPageWikiLink Clinical_chemistry.
- CLDN16 wikiPageWikiLink Dual-energy_X-ray_absorptiometry.
- CLDN16 wikiPageWikiLink Gene.
- CLDN16 wikiPageWikiLink Glucose_tolerance_test.
- CLDN16 wikiPageWikiLink Hematology.
- CLDN16 wikiPageWikiLink Hot_plate_test.
- CLDN16 wikiPageWikiLink Hypercalciuria.
- CLDN16 wikiPageWikiLink Hypomagnesemia.
- CLDN16 wikiPageWikiLink Indirect_calorimetry.
- CLDN16 wikiPageWikiLink International_Knockout_Mouse_Consortium.
- CLDN16 wikiPageWikiLink Knockout_mouse.
- CLDN16 wikiPageWikiLink Micronucleus_test.
- CLDN16 wikiPageWikiLink Model_organism.
- CLDN16 wikiPageWikiLink Mutant.
- CLDN16 wikiPageWikiLink Nephrocalcinosis.
- CLDN16 wikiPageWikiLink Open_Field_(animal_test).
- CLDN16 wikiPageWikiLink Peripheral_blood_lymphocyte.
- CLDN16 wikiPageWikiLink Phenotypic_screening.
- CLDN16 wikiPageWikiLink Protein.
- CLDN16 wikiPageWikiLink Radiography.
- CLDN16 wikiPageWikiLink Salmonella.
- CLDN16 wikiPageWikiLink Teratology.
- CLDN16 wikiPageWikiLink Urolithiasis.
- CLDN16 wikiPageWikiLink Zygosity.
- CLDN16 wikiPageWikiLinkText "CLDN16".
- CLDN16 wikiPageWikiLinkText "Claudin-16".
- CLDN16 requireManualInspection "no".
- CLDN16 summaryText "Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are composed of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is found primarily in the kidneys, specifically in the thick ascending limb of Henle, where it acts as either an intercellular pore or ion concentration sensor to regulate the paracellular resorption of magnesium ions. Defects in this gene are a cause of primary hypomagnesemia, which is characterized by massive renal magnesium wasting with hypomagnesemia and hypercalciuria, resulting in nephrocalcinosis and renal failure.".
- CLDN16 updateCitations "yes".
- CLDN16 updatePage "yes".
- CLDN16 updateProteinBox "yes".
- CLDN16 updateSummary "yes".
- CLDN16 wikiPageUsesTemplate Template:Cite_journal.
- CLDN16 wikiPageUsesTemplate Template:PBB.
- CLDN16 wikiPageUsesTemplate Template:PBB_Controls.
- CLDN16 wikiPageUsesTemplate Template:PBB_Further_reading.
- CLDN16 wikiPageUsesTemplate Template:PBB_Summary.
- CLDN16 wikiPageUsesTemplate Template:Refbegin.
- CLDN16 wikiPageUsesTemplate Template:Refend.
- CLDN16 wikiPageUsesTemplate Template:Reflist.
- CLDN16 subject Category:Genes_mutated_in_mice.
- CLDN16 hypernym Protein.
- CLDN16 type Biomolecule.
- CLDN16 type Protein.
- CLDN16 type Redirect.
- CLDN16 type Thing.
- CLDN16 type Q206229.
- CLDN16 type Q8054.
- CLDN16 comment "Claudin-16 is a protein that in humans is encoded by the CLDN16 gene. It belongs to the group of claudins.Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space.".
- CLDN16 label "CLDN16".
- CLDN16 sameAs Q18035605.
- CLDN16 sameAs m.03gz2wl.
- CLDN16 sameAs Q18035605.
- CLDN16 wasDerivedFrom CLDN16?oldid=697166775.
- CLDN16 isPrimaryTopicOf CLDN16.