Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/CCL20> ?p ?o }
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- CCL20 abstract "Chemokine (C-C motif) ligand 20 (CCL20) or liver activation regulated chemokine (LARC) or Macrophage Inflammatory Protein-3 (MIP3A) is a small cytokine belonging to the CC chemokine family. It is strongly chemotactic for lymphocytes and weakly attracts neutrophils. CCL20 is implicated in the formation and function of mucosal lymphoid tissues via chemoattraction of lymphocytes and dendritic cells towards the epithelial cells surrounding these tissues. CCL20 elicits its effects on its target cells by binding and activating the chemokine receptor CCR6.Gene expression of CCL20 can be induced by microbial factors such as lipopolysaccharide (LPS), and inflammatory cytokines such as tumor necrosis factor and interferon-γ, and down-regulated by IL-10. CCL20 is expressed in several tissues with highest expression observed in peripheral blood lymphocytes, lymph nodes, liver, appendix, and fetal lung and lower levels in thymus, testis, prostate and gut. The gene for CCL20 (scya20) is located on chromosome 2 in humans.Recent research in an animal model of multiple sclerosis known as experimental autoimmune encephalitis (EAE) demonstrated that regional neural activation can create \"gates\" for pathogenic CD4+ T cells to enter the CNS by increasing CCL20 expression, especially at L5. Sensory nerve stimulation, elicited by using muscles in the leg or electrical stimulation as in Arima et al., 2012, activates sympathetic neurons whose axons run through the dorsal root ganglia containing cell bodies of the stimulated afferent sensory nerve. Sympathetic neuronal activity activates IL-6 amplifier resulting in increased regional CCL20 expression and subsequent pathogenic CD4+ T cell accumulation at the same spinal cord level. CCL20 expression was observed to be dependent on IL-6 amplifier activation, which is dependent on NF-κB and STAT3 activation. This research provides evidence for a critical role for CCL20 in autoimmune pathogenesis of the central nervous system.".
- CCL20 entrezgene "6364".
- CCL20 wikiPageID "8472500".
- CCL20 wikiPageLength "15170".
- CCL20 wikiPageOutDegree "27".
- CCL20 wikiPageRevisionID "673170401".
- CCL20 wikiPageWikiLink Appendix_(anatomy).
- CCL20 wikiPageWikiLink CC_chemokine_receptors.
- CCL20 wikiPageWikiLink Category:Cytokines.
- CCL20 wikiPageWikiLink Chemokine.
- CCL20 wikiPageWikiLink Chemokine_receptor.
- CCL20 wikiPageWikiLink Chemotaxis.
- CCL20 wikiPageWikiLink Cytokine.
- CCL20 wikiPageWikiLink Dendritic_cell.
- CCL20 wikiPageWikiLink Epithelium.
- CCL20 wikiPageWikiLink Fetus.
- CCL20 wikiPageWikiLink Gene.
- CCL20 wikiPageWikiLink Interferon.
- CCL20 wikiPageWikiLink Interleukin_10.
- CCL20 wikiPageWikiLink Lipopolysaccharide.
- CCL20 wikiPageWikiLink Liver.
- CCL20 wikiPageWikiLink Lung.
- CCL20 wikiPageWikiLink Lymph_node.
- CCL20 wikiPageWikiLink Lymphatic_system.
- CCL20 wikiPageWikiLink Lymphocyte.
- CCL20 wikiPageWikiLink Microorganism.
- CCL20 wikiPageWikiLink Mucous_membrane.
- CCL20 wikiPageWikiLink NF-κB.
- CCL20 wikiPageWikiLink Neutrophil_granulocyte.
- CCL20 wikiPageWikiLink STAT3.
- CCL20 wikiPageWikiLink Tumor_necrosis_factors.
- CCL20 wikiPageWikiLinkText "CCL20".
- CCL20 requireManualInspection "no".
- CCL20 updateCitations "yes".
- CCL20 updatePage "yes".
- CCL20 updateProteinBox "yes".
- CCL20 updateSummary "no".
- CCL20 wikiPageUsesTemplate Template:Chemokines.
- CCL20 wikiPageUsesTemplate Template:Cite_journal.
- CCL20 wikiPageUsesTemplate Template:PBB.
- CCL20 wikiPageUsesTemplate Template:PBB_Controls.
- CCL20 wikiPageUsesTemplate Template:PBB_Further_reading.
- CCL20 wikiPageUsesTemplate Template:PDB_Gallery.
- CCL20 wikiPageUsesTemplate Template:Refbegin.
- CCL20 wikiPageUsesTemplate Template:Refend.
- CCL20 wikiPageUsesTemplate Template:Reflist.
- CCL20 subject Category:Cytokines.
- CCL20 hypernym Cytokine.
- CCL20 type Biomolecule.
- CCL20 type Protein.
- CCL20 type Thing.
- CCL20 type Q206229.
- CCL20 type Q8054.
- CCL20 comment "Chemokine (C-C motif) ligand 20 (CCL20) or liver activation regulated chemokine (LARC) or Macrophage Inflammatory Protein-3 (MIP3A) is a small cytokine belonging to the CC chemokine family. It is strongly chemotactic for lymphocytes and weakly attracts neutrophils. CCL20 is implicated in the formation and function of mucosal lymphoid tissues via chemoattraction of lymphocytes and dendritic cells towards the epithelial cells surrounding these tissues.".
- CCL20 label "CCL20".
- CCL20 sameAs Q14907657.
- CCL20 sameAs CCL20.
- CCL20 sameAs m.0274qhj.
- CCL20 sameAs CCL20.
- CCL20 sameAs CCL20.
- CCL20 sameAs Q14907657.
- CCL20 wasDerivedFrom CCL20?oldid=673170401.
- CCL20 isPrimaryTopicOf CCL20.