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- CAMP_receptor_protein abstract "cAMP receptor protein (CRP; also known as catabolite activator protein, CAP) is a regulatory protein in bacteria. CRP protein binds cAMP, which causes a conformational change that allows CRP to bind tightly to a specific DNA site in the promoters of the genes it controls. CRP then activates transcription through direct protein-protein interactions with RNA polymerase.The genes regulated by CRP are mostly involved in energy metabolism, such as galactose, citrate, or the PEP group translocation system. In Escherichia coli, cyclic AMP receptor protein (CRP) can regulate the transcription of more than 100 genes. The signal to activate CRP is the binding of cyclic AMP. Binding of cAMP to CRP leads to a long-distance signal transduction from the N-terminal cAMP-binding domain to the C-terminal domain of the protein, which is responsible for interaction with specific sequences of DNA.At \"Class I\" CRP-dependent promoters, CRP binds to a DNA site located upstream of core promoter elements and activates transcription through protein-protein interactions between \"activating region 1\" of CRP and the C-terminal domain of RNA polymerase alpha subunit. At \"Class II\" CRP-dependent promoters, CRP binds to a DNA site that overlaps the promoter -35 element and activates transcription through two sets of protein-protein interactions: (1) an interaction between \"activating region 1\" of CRP and the C-terminal domain of RNA polymerase alpha subunit, and (2) an interaction between \"activating region 2\" of CRP and the N-terminal domain of RNA polymerase alpha subunit. At \"Class III\" CRP-dependent promoters, CRP functions together with one or more \"co-activator\" proteins.At most CRP-dependent promoters, CRP activates transcription primarily or exclusively through a \"recruitment\" mechanism, in which protein-protein interactions between CRP and RNA polymerase assist binding of RNA polymerase to the promoter.".
- CAMP_receptor_protein entrezgene "947867".
- CAMP_receptor_protein pdb "1I5Z".
- CAMP_receptor_protein refseq "NP_417816.1".
- CAMP_receptor_protein symbol "CAP".
- CAMP_receptor_protein symbol "CRP".
- CAMP_receptor_protein thumbnail 1i5z.jpg?width=300.
- CAMP_receptor_protein uniprot "P0ACJ8".
- CAMP_receptor_protein wikiPageID "9589505".
- CAMP_receptor_protein wikiPageLength "4785".
- CAMP_receptor_protein wikiPageOutDegree "18".
- CAMP_receptor_protein wikiPageRevisionID "679027323".
- CAMP_receptor_protein wikiPageWikiLink Bacteria.
- CAMP_receptor_protein wikiPageWikiLink Catabolite_activator_protein.
- CAMP_receptor_protein wikiPageWikiLink Category:Bacterial_proteins.
- CAMP_receptor_protein wikiPageWikiLink Citric_acid.
- CAMP_receptor_protein wikiPageWikiLink Coactivator_(genetics).
- CAMP_receptor_protein wikiPageWikiLink Cyclic_adenosine_monophosphate.
- CAMP_receptor_protein wikiPageWikiLink Escherichia_coli.
- CAMP_receptor_protein wikiPageWikiLink Galactose.
- CAMP_receptor_protein wikiPageWikiLink PEP_group_translocation.
- CAMP_receptor_protein wikiPageWikiLink Promoter_(genetics).
- CAMP_receptor_protein wikiPageWikiLink Protein.
- CAMP_receptor_protein wikiPageWikiLink RNA_polymerase.
- CAMP_receptor_protein wikiPageWikiLink Regulation_of_gene_expression.
- CAMP_receptor_protein wikiPageWikiLinkText "AMP-CRP".
- CAMP_receptor_protein wikiPageWikiLinkText "CAMP receptor protein".
- CAMP_receptor_protein wikiPageWikiLinkText "CRP".
- CAMP_receptor_protein wikiPageWikiLinkText "cAMP Receptor Protein".
- CAMP_receptor_protein wikiPageWikiLinkText "cAMP receptor family".
- CAMP_receptor_protein wikiPageWikiLinkText "cAMP receptor protein".
- CAMP_receptor_protein altsymbols "CAP".
- CAMP_receptor_protein caption "Structure of the E. coli Cyclic AMP Receptor Protein.".
- CAMP_receptor_protein entrezgene "947867".
- CAMP_receptor_protein name "CAMP receptor protein".
- CAMP_receptor_protein pdb "1".
- CAMP_receptor_protein refseq "NP_417816.1".
- CAMP_receptor_protein symbol "CRP".
- CAMP_receptor_protein uniprot "P0ACJ8".
- CAMP_receptor_protein wikiPageUsesTemplate Template:Lowercase.
- CAMP_receptor_protein wikiPageUsesTemplate Template:Protein.
- CAMP_receptor_protein wikiPageUsesTemplate Template:Reflist.
- CAMP_receptor_protein subject Category:Bacterial_proteins.
- CAMP_receptor_protein hypernym Protein.
- CAMP_receptor_protein type Biomolecule.
- CAMP_receptor_protein type Protein.
- CAMP_receptor_protein type Chemical.
- CAMP_receptor_protein type Thing.
- CAMP_receptor_protein type Q206229.
- CAMP_receptor_protein type Q8054.
- CAMP_receptor_protein comment "cAMP receptor protein (CRP; also known as catabolite activator protein, CAP) is a regulatory protein in bacteria. CRP protein binds cAMP, which causes a conformational change that allows CRP to bind tightly to a specific DNA site in the promoters of the genes it controls.".
- CAMP_receptor_protein label "CAMP receptor protein".
- CAMP_receptor_protein sameAs Q5008668.
- CAMP_receptor_protein sameAs m.02pl0wg.
- CAMP_receptor_protein sameAs Q5008668.
- CAMP_receptor_protein sameAs CAMP受体蛋白.
- CAMP_receptor_protein wasDerivedFrom CAMP_receptor_protein?oldid=679027323.
- CAMP_receptor_protein depiction 1i5z.jpg.
- CAMP_receptor_protein isPrimaryTopicOf CAMP_receptor_protein.
- CAMP_receptor_protein name "CAMP receptor protein".