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- C3b abstract "C3b is the larger of two elements formed by the cleavage of complement component 3, and is considered an important part of the innate immune system. C3b is potent in opsonization:tagging pathogens, immune complexes (antigen-antibody), and apoptotic cells for phagocytosis. Additionally, C3b plays a role in forming a C3 convertase when bound to Factor B (C3bBb complex), or a C5 convertase when bound to C4b and C2a (C4b2a3b complex) or when an additional C3b molecule binds to the C3bBb complex (C3bBb3b complex).C3b's ability to perform these important functions derives from its ability to covalently bind to the surface of invading pathogens within an organism's body. The cleavage of C3 leaves C3b with an exposed thioester bond, allowing C3b to effectively coat and tag foreign cells by covalently binding to hydroxyl (-OH) and amine (-NH2) groups on foreign cell surfaces.This cleavage can occur via three mechanisms (classical pathway, alternative pathway and mannose binding lectin) that ultimately lead to the formation of a C3 convertase. Formation of a C3 convertase functions as a positive feedback loop, so as more C3b is cleaved, more C3 convertases are formed, further amplifying the signal on the surface the microbial invader. This amplification of signal serves as a powerful tool for the immune system in effective clearance of the invading pathogen.".
- C3b thumbnail Complement_pathway.svg?width=300.
- C3b wikiPageExternalLink ch163d.html.
- C3b wikiPageID "10406621".
- C3b wikiPageLength "9095".
- C3b wikiPageOutDegree "31".
- C3b wikiPageRevisionID "707863085".
- C3b wikiPageWikiLink Alternative_complement_pathway.
- C3b wikiPageWikiLink Antibody.
- C3b wikiPageWikiLink Antigen.
- C3b wikiPageWikiLink Apoptosis.
- C3b wikiPageWikiLink B_cell.
- C3b wikiPageWikiLink C3-convertase.
- C3b wikiPageWikiLink C5-convertase.
- C3b wikiPageWikiLink C8_complex.
- C3b wikiPageWikiLink Category:Complement_system.
- C3b wikiPageWikiLink Classical_complement_pathway.
- C3b wikiPageWikiLink Complement_component_2.
- C3b wikiPageWikiLink Complement_component_3.
- C3b wikiPageWikiLink Complement_component_4.
- C3b wikiPageWikiLink Complement_component_6.
- C3b wikiPageWikiLink Complement_component_7.
- C3b wikiPageWikiLink Complement_component_9.
- C3b wikiPageWikiLink Complement_factor_B.
- C3b wikiPageWikiLink Complement_receptor_1.
- C3b wikiPageWikiLink Covalent_bond.
- C3b wikiPageWikiLink Factor_D.
- C3b wikiPageWikiLink Immune_complex.
- C3b wikiPageWikiLink Immunoglobulin_G.
- C3b wikiPageWikiLink Immunoglobulin_M.
- C3b wikiPageWikiLink Macrophage.
- C3b wikiPageWikiLink Mannan-binding_lectin.
- C3b wikiPageWikiLink Mononuclear_phagocyte_system.
- C3b wikiPageWikiLink Neutrophil_granulocyte.
- C3b wikiPageWikiLink Opsonin.
- C3b wikiPageWikiLink Phagocytosis.
- C3b wikiPageWikiLink Properdin.
- C3b wikiPageWikiLink File:Complement_pathway.svg.
- C3b wikiPageWikiLinkText "C3b".
- C3b wikiPageUsesTemplate Template:Complement_system.
- C3b wikiPageUsesTemplate Template:Reflist.
- C3b subject Category:Complement_system.
- C3b comment "C3b is the larger of two elements formed by the cleavage of complement component 3, and is considered an important part of the innate immune system. C3b is potent in opsonization:tagging pathogens, immune complexes (antigen-antibody), and apoptotic cells for phagocytosis.".
- C3b label "C3b".
- C3b sameAs Q5008164.
- C3b sameAs C3b.
- C3b sameAs m.043ttf_.
- C3b sameAs Q5008164.
- C3b wasDerivedFrom C3b?oldid=707863085.
- C3b depiction Complement_pathway.svg.
- C3b isPrimaryTopicOf C3b.
