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- Butyrate abstract "Butyrate (also known as butanoate) is the traditional name for the conjugate base of butyric acid (also known as butanoic acid). The formula of the butyrate ion is C4H7O2−. The name is used as part of the name of esters and salts of butyric acid, a short chain fatty acid. Examples include Cellulose acetate butyrate, an aircraft dope Methyl butyrate Ethyl butyrate Butyl butyrate Pentyl butyrate Sodium butyrate, a HDAC inhibitor used in psychiatryButyrates are important as food for cells lining the mammalian colon (colonocytes). Without butyrates for energy, colon cells undergo autophagy (self digestion) and die.Short-chain fatty acids, which include butyrate, are produced by beneficial colonic bacteria (probiotics) that feed on, or ferment prebiotics, which are plant products that contain adequate amounts of dietary fiber. These short-chain fatty acids benefit the colonocytes (cells of the colon) by increasing energy production and cell proliferation, and may protect against colon cancer.Butyrate is a major metabolite in colonic lumen arising from bacterial fermentation of dietary fiber and has been shown to be a critical mediator of the colonic inflammatory response. Butyrate possesses both preventive and therapeutic potential to counteract inflammation-mediated ulcerative colitis (UC) and colorectal cancer. One mechanism underlying butyrate function in suppression of colonic inflammation is inhibition of the IFN-γ/STAT1 signaling pathways at least partially through acting as a histone deacetylase (HDAC) inhibitor. While transient IFN-γ signaling is generally associated with normal host immune response, chronic IFN-γ signaling is often associated with chronic inflammation. It has been shown that Butyrate inhibits activity of HDAC1 that is bound to the Fas gene promoter in T cells, resulting in hyperacetylation of the Fas promoter and up-regulation of Fas receptor on the T cell surface. It is thus suggested that Butyrate enhances apoptosis of T cells in the colonic tissue and thereby eliminates the source of inflammation (IFN-γ production). Butyrate inhibits angiogenesis by inactivating Sp1 transcription factor activity and down regulating vascular endothelial growth factor gene expression.".
- Butyrate iupacName "butanoate".
- Butyrate thumbnail Butyrate.svg?width=300.
- Butyrate wikiPageID "394368".
- Butyrate wikiPageLength "4943".
- Butyrate wikiPageOutDegree "29".
- Butyrate wikiPageRevisionID "704981769".
- Butyrate wikiPageWikiLink Aircraft_dope.
- Butyrate wikiPageWikiLink Apoptosis.
- Butyrate wikiPageWikiLink Autophagy.
- Butyrate wikiPageWikiLink Butyl_butyrate.
- Butyrate wikiPageWikiLink Butyric_acid.
- Butyrate wikiPageWikiLink Category:Butyrates.
- Butyrate wikiPageWikiLink Category:Carboxylate_anions.
- Butyrate wikiPageWikiLink Cellulose_acetate_butyrate.
- Butyrate wikiPageWikiLink Colorectal_cancer.
- Butyrate wikiPageWikiLink Conjugate_acid.
- Butyrate wikiPageWikiLink Ester.
- Butyrate wikiPageWikiLink Ethyl_butyrate.
- Butyrate wikiPageWikiLink Fas_receptor.
- Butyrate wikiPageWikiLink Gut_flora.
- Butyrate wikiPageWikiLink HDAC1.
- Butyrate wikiPageWikiLink Histone_deacetylase_inhibitor.
- Butyrate wikiPageWikiLink Interferon-gamma.
- Butyrate wikiPageWikiLink Large_intestine.
- Butyrate wikiPageWikiLink Methyl_butyrate.
- Butyrate wikiPageWikiLink Pentyl_butyrate.
- Butyrate wikiPageWikiLink Probiotic.
- Butyrate wikiPageWikiLink STAT1.
- Butyrate wikiPageWikiLink Salt_(chemistry).
- Butyrate wikiPageWikiLink Short-chain_fatty_acid.
- Butyrate wikiPageWikiLink Sodium_butyrate.
- Butyrate wikiPageWikiLink T_cell.
- Butyrate wikiPageWikiLink Ulcerative_colitis.
- Butyrate wikiPageWikiLink Vascular_endothelial_growth_factor.
- Butyrate wikiPageWikiLinkText "Butyrate".
- Butyrate wikiPageWikiLinkText "butyrate".
- Butyrate imagefile "Butyrate.svg".
- Butyrate iupacname "butanoate".
- Butyrate wikiPageUsesTemplate Template:Chembox.
- Butyrate wikiPageUsesTemplate Template:Chembox_Hazards.
- Butyrate wikiPageUsesTemplate Template:Chembox_Identifiers.
- Butyrate wikiPageUsesTemplate Template:Chembox_Properties.
- Butyrate wikiPageUsesTemplate Template:Chemspidercite.
- Butyrate wikiPageUsesTemplate Template:Reflist.
- Butyrate wikiPageUsesTemplate Template:Stdinchicite.
- Butyrate subject Category:Butyrates.
- Butyrate subject Category:Carboxylate_anions.
- Butyrate hypernym Name.
- Butyrate type ChemicalCompound.
- Butyrate type ChemicalSubstance.
- Butyrate type Chemical.
- Butyrate type ChemicalObject.
- Butyrate type Thing.
- Butyrate type Concept.
- Butyrate type Q11173.
- Butyrate comment "Butyrate (also known as butanoate) is the traditional name for the conjugate base of butyric acid (also known as butanoic acid). The formula of the butyrate ion is C4H7O2−. The name is used as part of the name of esters and salts of butyric acid, a short chain fatty acid.".
- Butyrate label "Butyrate".
- Butyrate sameAs Q1018145.
- Butyrate sameAs Бутират.
- Butyrate sameAs Buttersäureester.
- Butyrate sameAs Butyraatti.
- Butyrate sameAs Butanoate.
- Butyrate sameAs Butirāti.
- Butyrate sameAs Butyraat.
- Butyrate sameAs Maślany.
- Butyrate sameAs m.0117ffjz.
- Butyrate sameAs Butirat.
- Butyrate sameAs Butirat.
- Butyrate sameAs Q1018145.
- Butyrate wasDerivedFrom Butyrate?oldid=704981769.
- Butyrate depiction Butyrate.svg.
- Butyrate isPrimaryTopicOf Butyrate.