Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Butriptyline> ?p ?o }
- Butriptyline abstract "Butriptyline (Evadene, Evadyne, Evasidol, Centrolese) is a tricyclic antidepressant (TCA) which has been used in Europe since 1974. It is the isobutyl side chain homologue of amitriptyline and produces similar effects to it, but with less marked side effects like sedation and interactions with adrenergic drugs.In vitro, butriptyline is a strong antihistamine and anticholinergic, moderate 5-HT2 and α1-adrenergic receptor antagonist, and weak serotonin reuptake inhibitor, with negligible affinity for the norepinephrine and dopamine transporters. These actions appear to confer a profile similar to that of iprindole and trimipramine with serotonin-blocking effects as the predominant mediator of mood-lifting efficacy.However, in clinical trials, using similar doses, butriptyline was found to be even more effective than amitriptyline as an antidepressant, despite the fact that amitriptyline is far stronger as both a 5-HT2 antagonist and serotonin-norepinephrine reuptake inhibitor. As a result, it may be that butriptyline, in vivo, functions as a prodrug to a metabolite with more appreciable pharmacodynamics.".
- Butriptyline atcPrefix "N06".
- Butriptyline atcSuffix "AA15".
- Butriptyline casNumber "35941-65-2".
- Butriptyline drugbank "DB09016".
- Butriptyline fdaUniiCode "Z22441975X".
- Butriptyline iupacName "(±)-3-(10,11-dihydro-5H-dibenzo[a,d]cycloheptene-5-yl)-N,N,2-trimethylpropan-1-amine".
- Butriptyline pubchem "21772".
- Butriptyline thumbnail Butriptyline.svg?width=300.
- Butriptyline wikiPageID "5900878".
- Butriptyline wikiPageLength "8197".
- Butriptyline wikiPageOutDegree "33".
- Butriptyline wikiPageRevisionID "707072162".
- Butriptyline wikiPageWikiLink 5-HT2_receptor.
- Butriptyline wikiPageWikiLink Adrenergic.
- Butriptyline wikiPageWikiLink Alpha-1_adrenergic_receptor.
- Butriptyline wikiPageWikiLink Amitriptyline.
- Butriptyline wikiPageWikiLink Anticholinergic.
- Butriptyline wikiPageWikiLink Antihistamine.
- Butriptyline wikiPageWikiLink Butyl.
- Butriptyline wikiPageWikiLink Category:Dibenzocycloheptenes.
- Butriptyline wikiPageWikiLink Category:Tricyclic_antidepressants.
- Butriptyline wikiPageWikiLink Clinical_trial.
- Butriptyline wikiPageWikiLink Dopamine_transporter.
- Butriptyline wikiPageWikiLink Drug_interaction.
- Butriptyline wikiPageWikiLink Europe.
- Butriptyline wikiPageWikiLink Homology_(chemistry).
- Butriptyline wikiPageWikiLink In_vitro.
- Butriptyline wikiPageWikiLink In_vivo.
- Butriptyline wikiPageWikiLink Iprindole.
- Butriptyline wikiPageWikiLink Ligand_(biochemistry).
- Butriptyline wikiPageWikiLink Metabolite.
- Butriptyline wikiPageWikiLink Norepinephrine_transporter.
- Butriptyline wikiPageWikiLink Pharmacodynamics.
- Butriptyline wikiPageWikiLink Prodrug.
- Butriptyline wikiPageWikiLink Racemic_mixture.
- Butriptyline wikiPageWikiLink Receptor_antagonist.
- Butriptyline wikiPageWikiLink Sedation.
- Butriptyline wikiPageWikiLink Serotonin.
- Butriptyline wikiPageWikiLink Serotonin_reuptake_inhibitor.
- Butriptyline wikiPageWikiLink Serotonin–norepinephrine_reuptake_inhibitor.
- Butriptyline wikiPageWikiLink Side_chain.
- Butriptyline wikiPageWikiLink Side_effect.
- Butriptyline wikiPageWikiLink Tricyclic_antidepressant.
- Butriptyline wikiPageWikiLink Trimipramine.
- Butriptyline wikiPageWikiLinkText "Butriptyline".
- Butriptyline wikiPageWikiLinkText "butriptyline".
- Butriptyline atcPrefix "N06".
- Butriptyline atcSuffix "AA15".
- Butriptyline c "21".
- Butriptyline casNumber "35941".
- Butriptyline chembl "2110816".
- Butriptyline chemspiderid "20462".
- Butriptyline chirality Racemic_mixture.
- Butriptyline drugbank "DB09016".
- Butriptyline eliminationHalfLife "72000.0".
- Butriptyline h "27".
- Butriptyline inchi "1".
- Butriptyline inchikey "ALELTFCQZDXAMQ-UHFFFAOYAG".
- Butriptyline iupacName "-3".
- Butriptyline kegg "D07601".
- Butriptyline legalStatus "Rx-only".
- Butriptyline molecularWeight "293.446".
- Butriptyline n "1".
- Butriptyline pubchem "21772".
- Butriptyline routesOfAdministration "Oral".
- Butriptyline smiles "c1cc3cCCc2cC3CCCNC".
- Butriptyline stdinchi "1".
- Butriptyline stdinchikey "ALELTFCQZDXAMQ-UHFFFAOYSA-N".
- Butriptyline unii "Z22441975X".
- Butriptyline verifiedfields "changed".
- Butriptyline verifiedrevid "447573132".
- Butriptyline wikiPageUsesTemplate Template:Adrenergics.
- Butriptyline wikiPageUsesTemplate Template:Antidepressants.
- Butriptyline wikiPageUsesTemplate Template:Cascite.
- Butriptyline wikiPageUsesTemplate Template:Chemspidercite.
- Butriptyline wikiPageUsesTemplate Template:Cholinergics.
- Butriptyline wikiPageUsesTemplate Template:Drugbankcite.
- Butriptyline wikiPageUsesTemplate Template:Drugbox.
- Butriptyline wikiPageUsesTemplate Template:Ebicite.
- Butriptyline wikiPageUsesTemplate Template:Fdacite.
- Butriptyline wikiPageUsesTemplate Template:Histaminergics.
- Butriptyline wikiPageUsesTemplate Template:Keggcite.
- Butriptyline wikiPageUsesTemplate Template:Nervous-system-drug-stub.
- Butriptyline wikiPageUsesTemplate Template:Reflist.
- Butriptyline wikiPageUsesTemplate Template:Serotonergics.
- Butriptyline wikiPageUsesTemplate Template:Stdinchicite.
- Butriptyline wikiPageUsesTemplate Template:Tricyclics.
- Butriptyline subject Category:Dibenzocycloheptenes.
- Butriptyline subject Category:Tricyclic_antidepressants.
- Butriptyline hypernym Antidepressant.
- Butriptyline type ChemicalSubstance.
- Butriptyline type Drug.
- Butriptyline type Antidepressant.
- Butriptyline type Drug.
- Butriptyline type Hydrocarbon.
- Butriptyline type Inhibitor.
- Butriptyline type Redirect.
- Butriptyline type ChemicalObject.
- Butriptyline type Thing.