Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Bupropion> ?p ?o }
- Bupropion abstract "Bupropion or bupropion hydrochloride, also known formerly as amfebutamone, is a medication primarily used as an antidepressant and smoking cessation aid. It is marketed as Wellbutrin and Zyban among other trade names. It is one of the most frequently prescribed antidepressants in the United States and Canada, although in many English-speaking countries, including the United Kingdom, Australia and New Zealand, this is an off-label use. Bupropion is taken in tablet form and is available only by prescription in most countries. Chemically, bupropion is in the aminoketone family.Bupropion serves as an atypical antidepressant different from most commonly prescribed antidepressants such as selective serotonin reuptake inhibitors (SSRIs). It is an effective antidepressant on its own, but is also popular as an add-on medication in cases of incomplete response to first-line SSRI antidepressants. In comparison to many other antidepressants, it does not cause as much weight gain or sexual dysfunction. The most important side effect is an increase in risk for epileptic seizures, which caused the drug to be withdrawn from the market for some time and then caused the recommended dosage to be reduced.Bupropion is known to affect several different biological targets, and its mechanism of action is only partly understood. It has been widely described in the literature as a norepinephrine-dopamine reuptake inhibitor (NDRI), and is also a nicotinic antagonist. However, the picture may be more complicated than this, as bupropion does not appear to have significant dopaminergic actions in humans under normal clinical circumstances. Chemically, bupropion belongs to the class of aminoketones and is similar in structure to stimulants such as cathinone and amfepramone, and to phenethylamines in general.Bupropion was synthesized by Nariman Mehta and patented by Burroughs Wellcome in 1969, which later became part of what is now GlaxoSmithKline. It was first approved for clinical use in the United States in 1989. It was originally called by the generic name amfebutamone, before being renamed in 2000. Its chemical name is 3-chloro-N-tert-butyl-β-ketoamphetamine. It is a substituted cathinone (β-ketoamphetamine), and by extension, a substituted amphetamine.".
- Bupropion atcPrefix "N06".
- Bupropion atcSuffix "AX12".
- Bupropion casNumber "34841-39-9".
- Bupropion chEBI "3219".
- Bupropion drugbank "DB01156".
- Bupropion fdaUniiCode "01ZG3TPX31".
- Bupropion iupacName "(±)-2-(tert-Butylamino)-1-(3-chlorophenyl)propan-1-one".
- Bupropion pubchem "444".
- Bupropion thumbnail Bupropion_1.svg?width=300.
- Bupropion wikiPageExternalLink bupropion.html.
- Bupropion wikiPageExternalLink www.wellbutrin-xl.com.
- Bupropion wikiPageID "378579".
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- Bupropion wikiPageOutDegree "199".
- Bupropion wikiPageRevisionID "706840353".
- Bupropion wikiPageWikiLink 11β-hydroxysteroid_dehydrogenase_type_1.
- Bupropion wikiPageWikiLink Active_metabolite.
- Bupropion wikiPageWikiLink Alpha-1_adrenergic_receptor.
- Bupropion wikiPageWikiLink Alpha-3_beta-2_nicotinic_receptor.
- Bupropion wikiPageWikiLink Alpha-3_beta-4_nicotinic_receptor.
- Bupropion wikiPageWikiLink Alpha-4_beta-2_nicotinic_receptor.
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- Bupropion wikiPageWikiLink Aminoketone.
- Bupropion wikiPageWikiLink Anorexia_nervosa.
- Bupropion wikiPageWikiLink Antidepressant.
- Bupropion wikiPageWikiLink Area_under_the_curve_(pharmacokinetics).
- Bupropion wikiPageWikiLink Atomoxetine.
- Bupropion wikiPageWikiLink Attention_deficit_hyperactivity_disorder.
- Bupropion wikiPageWikiLink Benzodiazepine.
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- Bupropion wikiPageWikiLink naltrexone.
- Bupropion wikiPageWikiLink CYP1A2.
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- Bupropion wikiPageWikiLink CYP3A4.
- Bupropion wikiPageWikiLink Canada.
- Bupropion wikiPageWikiLink Carbamazepine.
- Bupropion wikiPageWikiLink Carbapenem.
- Bupropion wikiPageWikiLink Category:Anorectics.
- Bupropion wikiPageWikiLink Category:Antidepressants.
- Bupropion wikiPageWikiLink Category:Antiobesity_drugs.
- Bupropion wikiPageWikiLink Category:Cathinones.
- Bupropion wikiPageWikiLink Category:Chloroarenes.
- Bupropion wikiPageWikiLink Category:Nicotinic_antagonists.
- Bupropion wikiPageWikiLink Category:Norepinephrine-dopamine_reuptake_inhibitors.
- Bupropion wikiPageWikiLink Category:Prodrugs.
- Bupropion wikiPageWikiLink Category:Sexual_dysfunction_drugs.
- Bupropion wikiPageWikiLink Category:Smoking_cessation.
- Bupropion wikiPageWikiLink Category:Stimulants.
- Bupropion wikiPageWikiLink Cathinone.
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- Bupropion wikiPageWikiLink Chloroquine.
- Bupropion wikiPageWikiLink Cholinergic.
- Bupropion wikiPageWikiLink Clomipramine.
- Bupropion wikiPageWikiLink Clopidogrel.
- Bupropion wikiPageWikiLink Clotrimazole.
- Bupropion wikiPageWikiLink Cocaine.
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- Bupropion wikiPageWikiLink Corticosteroid.
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- Bupropion wikiPageWikiLink Dissociation_constant.
- Bupropion wikiPageWikiLink Dopamine.
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- Bupropion wikiPageWikiLink Dopaminergic.
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- Bupropion wikiPageWikiLink Duloxetine.
- Bupropion wikiPageWikiLink Dystonia.
- Bupropion wikiPageWikiLink Enzyme_induction_and_inhibition.
- Bupropion wikiPageWikiLink Epilepsy.
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- Bupropion wikiPageWikiLink Erythrohydrobupropion.
- Bupropion wikiPageWikiLink Escitalopram.
- Bupropion wikiPageWikiLink Ethanol.
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- Bupropion wikiPageWikiLink File:Bupropion_metabolism.png.
- Bupropion wikiPageWikiLink First_pass_effect.
- Bupropion wikiPageWikiLink Fluoxetine.
- Bupropion wikiPageWikiLink Food_and_Drug_Administration.
- Bupropion wikiPageWikiLink Generic_drug.
- Bupropion wikiPageWikiLink GlaxoSmithKline.
- Bupropion wikiPageWikiLink Health_care_in_Australia.
- Bupropion wikiPageWikiLink Health_care_in_New_Zealand.
- Bupropion wikiPageWikiLink Healthcare_in_the_United_Kingdom.
- Bupropion wikiPageWikiLink Histamine_H1_receptor.
- Bupropion wikiPageWikiLink Hydrochloric_acid.
- Bupropion wikiPageWikiLink Hydroxybupropion.