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- Buprenorphine-3-glucuronide abstract "Buprenorphine-3-glucuronide (B3G) is a major active metabolite of the opioid modulator buprenorphine. It has affinity for the μ-opioid receptor (Ki = 4.9 (± 2.7) pM), δ-opioid receptor (Ki = 270 nM), and nociceptin receptor (Ki = 36 μM), but not for the κ-opioid receptor. Whether B3G acts as an agonist or antagonist of each of the former three respective sites has yet to be determined. In rats, at the doses assayed, B3G has been found to produce a small degree of antinociception, and similarly to buprenorphine in these assays, has not been found to produce sedation, reduce locomotion, or decrease respiratory rate. Of all of the active metabolites of buprenorphine, B3G is thought to be the most similar to the parent drug. Unlike norbuprenorphine, but similarly to buprenorphine (and norbuprenorphine-3-glucuronide), B3G is not a substrate for P-glycoprotein, and hence may cross the blood-brain-barrier significantly.".
- Buprenorphine-3-glucuronide atcPrefix "None".
- Buprenorphine-3-glucuronide casNumber "101224-22-0".
- Buprenorphine-3-glucuronide iupacName "(5α,6β,14β,18R)-17-(Cyclopropylmethyl)-18-[(2S)-2-hydroxy-3,3-dimethyl-2-butanyl]-6-methoxy-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-2-yl β-D-glucopyranosiduronic acid".
- Buprenorphine-3-glucuronide pubchem "127780".
- Buprenorphine-3-glucuronide thumbnail Buprenorphine-3-glucuronide.svg?width=300.
- Buprenorphine-3-glucuronide wikiPageID "44622703".
- Buprenorphine-3-glucuronide wikiPageLength "4502".
- Buprenorphine-3-glucuronide wikiPageOutDegree "27".
- Buprenorphine-3-glucuronide wikiPageRevisionID "696937458".
- Buprenorphine-3-glucuronide wikiPageWikiLink Active_metabolite.
- Buprenorphine-3-glucuronide wikiPageWikiLink Agonist.
- Buprenorphine-3-glucuronide wikiPageWikiLink Analgesic.
- Buprenorphine-3-glucuronide wikiPageWikiLink Animal_locomotion.
- Buprenorphine-3-glucuronide wikiPageWikiLink Blood–brain_barrier.
- Buprenorphine-3-glucuronide wikiPageWikiLink Buprenorphine.
- Buprenorphine-3-glucuronide wikiPageWikiLink Category:Alcohols.
- Buprenorphine-3-glucuronide wikiPageWikiLink Category:Ethers.
- Buprenorphine-3-glucuronide wikiPageWikiLink Category:Glucuronides.
- Buprenorphine-3-glucuronide wikiPageWikiLink Category:Morphinans.
- Buprenorphine-3-glucuronide wikiPageWikiLink Category:Opioid_metabolites.
- Buprenorphine-3-glucuronide wikiPageWikiLink Category:Oripavines.
- Buprenorphine-3-glucuronide wikiPageWikiLink Category:Phenols.
- Buprenorphine-3-glucuronide wikiPageWikiLink Ligand_(biochemistry).
- Buprenorphine-3-glucuronide wikiPageWikiLink Morphine-3-glucuronide.
- Buprenorphine-3-glucuronide wikiPageWikiLink Nociceptin_receptor.
- Buprenorphine-3-glucuronide wikiPageWikiLink Norbuprenorphine.
- Buprenorphine-3-glucuronide wikiPageWikiLink Norbuprenorphine-3-glucuronide.
- Buprenorphine-3-glucuronide wikiPageWikiLink Opioid_modulator.
- Buprenorphine-3-glucuronide wikiPageWikiLink P-glycoprotein.
- Buprenorphine-3-glucuronide wikiPageWikiLink Receptor_antagonist.
- Buprenorphine-3-glucuronide wikiPageWikiLink Respiratory_rate.
- Buprenorphine-3-glucuronide wikiPageWikiLink Sedation.
- Buprenorphine-3-glucuronide wikiPageWikiLink Substrate_(chemistry).
- Buprenorphine-3-glucuronide wikiPageWikiLink Δ-opioid_receptor.
- Buprenorphine-3-glucuronide wikiPageWikiLink Κ-opioid_receptor.
- Buprenorphine-3-glucuronide wikiPageWikiLink Μ-opioid_receptor.
- Buprenorphine-3-glucuronide wikiPageWikiLinkText "Buprenorphine-3-glucuronide".
- Buprenorphine-3-glucuronide wikiPageWikiLinkText "buprenorphine-3-glucuronide".
- Buprenorphine-3-glucuronide atcPrefix "None".
- Buprenorphine-3-glucuronide c "35".
- Buprenorphine-3-glucuronide casNumber "101224".
- Buprenorphine-3-glucuronide chemspiderid "113341".
- Buprenorphine-3-glucuronide h "49".
- Buprenorphine-3-glucuronide inchi "1".
- Buprenorphine-3-glucuronide inchikey "CZULHKGIAJASAA-WWIHBJMFBG".
- Buprenorphine-3-glucuronide iupacName "-17".
- Buprenorphine-3-glucuronide molecularWeight "643.764".
- Buprenorphine-3-glucuronide n "1".
- Buprenorphine-3-glucuronide o "10".
- Buprenorphine-3-glucuronide pubchem "127780".
- Buprenorphine-3-glucuronide smiles "C[C@]O".
- Buprenorphine-3-glucuronide stdinchi "1".
- Buprenorphine-3-glucuronide stdinchikey "CZULHKGIAJASAA-WWIHBJMFSA-N".
- Buprenorphine-3-glucuronide wikiPageUsesTemplate Template:Drugbox.
- Buprenorphine-3-glucuronide wikiPageUsesTemplate Template:Nervous-system-drug-stub.
- Buprenorphine-3-glucuronide wikiPageUsesTemplate Template:Opioidergics.
- Buprenorphine-3-glucuronide wikiPageUsesTemplate Template:Reflist.
- Buprenorphine-3-glucuronide subject Category:Alcohols.
- Buprenorphine-3-glucuronide subject Category:Ethers.
- Buprenorphine-3-glucuronide subject Category:Glucuronides.
- Buprenorphine-3-glucuronide subject Category:Morphinans.
- Buprenorphine-3-glucuronide subject Category:Opioid_metabolites.
- Buprenorphine-3-glucuronide subject Category:Oripavines.
- Buprenorphine-3-glucuronide subject Category:Phenols.
- Buprenorphine-3-glucuronide hypernym Metabolite.
- Buprenorphine-3-glucuronide type ChemicalCompound.
- Buprenorphine-3-glucuronide type ChemicalSubstance.
- Buprenorphine-3-glucuronide type Drug.
- Buprenorphine-3-glucuronide type ChemicalObject.
- Buprenorphine-3-glucuronide type Thing.
- Buprenorphine-3-glucuronide type Q8386.
- Buprenorphine-3-glucuronide comment "Buprenorphine-3-glucuronide (B3G) is a major active metabolite of the opioid modulator buprenorphine. It has affinity for the μ-opioid receptor (Ki = 4.9 (± 2.7) pM), δ-opioid receptor (Ki = 270 nM), and nociceptin receptor (Ki = 36 μM), but not for the κ-opioid receptor. Whether B3G acts as an agonist or antagonist of each of the former three respective sites has yet to be determined.".
- Buprenorphine-3-glucuronide label "Buprenorphine-3-glucuronide".
- Buprenorphine-3-glucuronide sameAs Q19596211.
- Buprenorphine-3-glucuronide sameAs m.012fxjpw.
- Buprenorphine-3-glucuronide sameAs Q19596211.
- Buprenorphine-3-glucuronide wasDerivedFrom Buprenorphine-3-glucuronide?oldid=696937458.
- Buprenorphine-3-glucuronide depiction Buprenorphine-3-glucuronide.svg.
- Buprenorphine-3-glucuronide isPrimaryTopicOf Buprenorphine-3-glucuronide.