Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Bowditch_effect> ?p ?o }
Showing triples 1 to 24 of
24
with 100 triples per page.
- Bowditch_effect abstract "The Bowditch effect is an autoregulation method by which myocardial tension increases with an increase in heart rate. Also known as the Treppe phenomenon, Treppe effect or staircase effect. It was first observed by Henry Pickering Bowditch in 1871.One of the explanations is the inability of the Na+/K+-ATPase to keep up with influx of sodium at higher heart rates. When a higher heart rate occurs, for example due to adrenergic stimulation, the L Type Calcium channel has increased activity. The 3Na+/Ca++ exchanger (which allows 3 Na to flow down its gradient in exchange for 1 Ca++ ion to flow out of the cell) works to decrease the levels of intracellular calcium. As the heart rate becomes more robust and the length of diastole decreases, the Na+/K+-ATPase which removes the Na+ brought into the cell by the Na/Ca exchanger does not keep up with the rate of Na influx. This leads to a less efficient Na/Ca exchange since the gradient is decreasing for sodium and the drive force behind calcium transport is actually the concentration gradient of sodium, therefore Ca++ builds up within the cell. This results in an accumulation of calcium in the myocardial cell via the sodium calcium exchanger. And leads to a greater state of inotropism, a mechanism which is also seen with cardiac glycosides.Alternatively, another mechanism is that the Na+-Ca++ membrane exchanger, which operates continually, has less time to remove the Ca++ that arrives in the cell because of the decreased length of diastole with positive chronotropy. With an increased intracellular Ca++ concentration, there follows a positive inotropy.".
- Bowditch_effect wikiPageID "11634579".
- Bowditch_effect wikiPageLength "1988".
- Bowditch_effect wikiPageOutDegree "6".
- Bowditch_effect wikiPageRevisionID "699130472".
- Bowditch_effect wikiPageWikiLink Category:Cardiovascular_diseases.
- Bowditch_effect wikiPageWikiLink Chronotropic.
- Bowditch_effect wikiPageWikiLink Henry_Pickering_Bowditch.
- Bowditch_effect wikiPageWikiLink Inotrope.
- Bowditch_effect wikiPageWikiLink K+-ATPase.
- Bowditch_effect wikiPageWikiLink Sodium-calcium_exchanger.
- Bowditch_effect wikiPageWikiLinkText "Bowditch effect".
- Bowditch_effect wikiPageUsesTemplate Template:Cardiovascular-stub.
- Bowditch_effect subject Category:Cardiovascular_diseases.
- Bowditch_effect hypernym Method.
- Bowditch_effect type Software.
- Bowditch_effect comment "The Bowditch effect is an autoregulation method by which myocardial tension increases with an increase in heart rate. Also known as the Treppe phenomenon, Treppe effect or staircase effect. It was first observed by Henry Pickering Bowditch in 1871.One of the explanations is the inability of the Na+/K+-ATPase to keep up with influx of sodium at higher heart rates. When a higher heart rate occurs, for example due to adrenergic stimulation, the L Type Calcium channel has increased activity.".
- Bowditch_effect label "Bowditch effect".
- Bowditch_effect sameAs Q4950752.
- Bowditch_effect sameAs تأثير_بوديتش.
- Bowditch_effect sameAs m.02rm843.
- Bowditch_effect sameAs Q4950752.
- Bowditch_effect wasDerivedFrom Bowditch_effect?oldid=699130472.
- Bowditch_effect isPrimaryTopicOf Bowditch_effect.