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- Bivalirudin abstract "Bivalirudin (Angiomax or Angiox, manufactured by The Medicines Company) is a specific and reversible direct thrombin inhibitor (DTI).Chemically, it is a synthetic congener of the naturally occurring drug hirudin (found in the saliva of the medicinal leech Hirudo medicinalis).Bivalirudin is a DTI that overcomes many limitations seen with indirect thrombin inhibitors, such as heparin. Bivalirudin is a short, synthetic peptide that is potent, highly specific, and a reversible inhibitor of thrombin. It inhibits both circulating and clot-bound thrombin, while also inhibiting thrombin-mediated platelet activation and aggregation. Bivalirudin has a quick onset of action and a short half-life. It does not bind to plasma proteins (other than thrombin) or to red blood cells. Therefore, it has a predictable antithrombotic response. There is no risk for Heparin Induced Thrombocytopenia/Heparin Induced Thrombosis-Thrombocytopenia Syndrome (HIT/HITTS). It does not require a binding cofactor such as antithrombin and does not activate platelets. These characteristics make bivalirudin an ideal alternative to heparin.Bivalirudin clinical studies demonstrated consistent positive outcomes in patients with stable angina, unstable angina (UA), non-ST segment elevation myocardial infarction (NSTEMI), and ST-segment elevation myocardial infarction (STEMI) undergoing PCI in 7 major randomized trials. Patients receiving bivalirudin had fewer adverse events compared to patients that received heparin.".
- Bivalirudin atcPrefix "B01".
- Bivalirudin atcSuffix "AE06".
- Bivalirudin casNumber "128270-60-0".
- Bivalirudin chEBI "59173".
- Bivalirudin drugbank "DB00006".
- Bivalirudin fdaUniiCode "TN9BEX005G".
- Bivalirudin pubchem "16129704".
- Bivalirudin thumbnail Bivalirudin.png?width=300.
- Bivalirudin wikiPageExternalLink heparin-more-effective-bivalirudin-treating-patients-during-pci.
- Bivalirudin wikiPageID "5787206".
- Bivalirudin wikiPageLength "35435".
- Bivalirudin wikiPageOutDegree "11".
- Bivalirudin wikiPageRevisionID "705017589".
- Bivalirudin wikiPageWikiLink Angina_pectoris.
- Bivalirudin wikiPageWikiLink Category:Direct_thrombin_inhibitors.
- Bivalirudin wikiPageWikiLink Category:Peptides.
- Bivalirudin wikiPageWikiLink Congener_(chemistry).
- Bivalirudin wikiPageWikiLink Direct_thrombin_inhibitor.
- Bivalirudin wikiPageWikiLink Discovery_and_development_of_direct_thrombin_inhibitors.
- Bivalirudin wikiPageWikiLink Heparin.
- Bivalirudin wikiPageWikiLink Heparin-induced_thrombocytopenia.
- Bivalirudin wikiPageWikiLink Hirudin.
- Bivalirudin wikiPageWikiLink Intravenous_therapy.
- Bivalirudin wikiPageWikiLink Thrombin.
- Bivalirudin wikiPageWikiLinkText "Bivalirudin".
- Bivalirudin wikiPageWikiLinkText "bivalirudin".
- Bivalirudin atcPrefix "B01".
- Bivalirudin atcSuffix "AE06".
- Bivalirudin bioavailability "N/A".
- Bivalirudin c "98".
- Bivalirudin casNumber "128270".
- Bivalirudin chebi "59173".
- Bivalirudin chembl "1201455".
- Bivalirudin chemspiderid "10482069".
- Bivalirudin drugbank "DB00006".
- Bivalirudin eliminationHalfLife "1500.0".
- Bivalirudin h "138".
- Bivalirudin inchi "1".
- Bivalirudin inchikey "OIRCOABEOLEUMC-GEJPAHFPBI".
- Bivalirudin iupharLigand "6470".
- Bivalirudin legalStatus "Rx-only. Not a controlled substance.".
- Bivalirudin metabolism "Angiomax is cleared from plasma by a combination of renal mechanisms and proteolytic cleavage".
- Bivalirudin molecularWeight "2180.29".
- Bivalirudin n "24".
- Bivalirudin o "33".
- Bivalirudin pregnancyUs "B".
- Bivalirudin pubchem "16129704".
- Bivalirudin routesOfAdministration "Intravenous injection/infusion only".
- Bivalirudin smiles "CC[C@H][C@@H]NC[C@H]NC[C@H]NC[C@H]NC[C@H]NCCNC[C@H]NCCNCCNCCNCCNC[C@@H]4CCCN4C[C@H]NC[C@@H]5CCCN5C[C@@H]N".
- Bivalirudin stdinchi "1".
- Bivalirudin stdinchikey "OIRCOABEOLEUMC-GEJPAHFPSA-N".
- Bivalirudin synonyms "-l-alpha-aspartyl-l-phenylalanyl".
- Bivalirudin synonyms "-l-alpha-glutamyl-l-alpha-glutamyl-l-isoleucyl".
- Bivalirudin synonyms "-l-prolyl-l-alpha-glutamyl-l-alpha-glutamyl".
- Bivalirudin synonyms "-l-prolylglycylglycylglycylglycyl-l-asparaginylglycyl".
- Bivalirudin synonyms "-l-tyrosyl-l-leucine".
- Bivalirudin synonyms "d-Phenylalanyl-l-prolyl-l-arginyl".
- Bivalirudin tradename "Angiomax".
- Bivalirudin unii "TN9BEX005G".
- Bivalirudin verifiedfields "changed".
- Bivalirudin verifiedrevid "459980478".
- Bivalirudin watchedfields "changed".
- Bivalirudin wikiPageUsesTemplate Template:Antithrombotics.
- Bivalirudin wikiPageUsesTemplate Template:Cascite.
- Bivalirudin wikiPageUsesTemplate Template:Chemspidercite.
- Bivalirudin wikiPageUsesTemplate Template:Drugbankcite.
- Bivalirudin wikiPageUsesTemplate Template:Drugbox.
- Bivalirudin wikiPageUsesTemplate Template:Drugs.com.
- Bivalirudin wikiPageUsesTemplate Template:Ebicite.
- Bivalirudin wikiPageUsesTemplate Template:Fdacite.
- Bivalirudin wikiPageUsesTemplate Template:Stdinchicite.
- Bivalirudin subject Category:Direct_thrombin_inhibitors.
- Bivalirudin subject Category:Peptides.
- Bivalirudin hypernym Inhibitor.
- Bivalirudin type ChemicalSubstance.
- Bivalirudin type Drug.
- Bivalirudin type Anticoagulant.
- Bivalirudin type Chemical.
- Bivalirudin type Inhibitor.
- Bivalirudin type Redirect.
- Bivalirudin type ChemicalObject.
- Bivalirudin type Thing.
- Bivalirudin type Q8386.
- Bivalirudin comment "Bivalirudin (Angiomax or Angiox, manufactured by The Medicines Company) is a specific and reversible direct thrombin inhibitor (DTI).Chemically, it is a synthetic congener of the naturally occurring drug hirudin (found in the saliva of the medicinal leech Hirudo medicinalis).Bivalirudin is a DTI that overcomes many limitations seen with indirect thrombin inhibitors, such as heparin.".
- Bivalirudin label "Bivalirudin".
- Bivalirudin sameAs Q4919218.
- Bivalirudin sameAs Bivalirudin.
- Bivalirudin sameAs Bivalirudine.
- Bivalirudin sameAs Bivalirudina.
- Bivalirudin sameAs Biwalirudyna.
- Bivalirudin sameAs Bivalirudina.
- Bivalirudin sameAs m.0f4k3z.
- Bivalirudin sameAs Bivalirudin.
- Bivalirudin sameAs Bivalirudin.
- Bivalirudin sameAs Q4919218.
- Bivalirudin wasDerivedFrom Bivalirudin?oldid=705017589.
- Bivalirudin depiction Bivalirudin.png.
- Bivalirudin isPrimaryTopicOf Bivalirudin.