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- Biopterin-dependent_aromatic_amino_acid_hydroxylase abstract "In molecular biology, the biopterin-dependent aromatic amino acid hydroxylases (abbreviated AAAH) constitute a family of aromatic amino acid hydroxylases, including phenylalanine 4-hydroxylase (EC 1.14.16.1), tyrosine 3-hydroxylase (EC 1.14.16.2), and tryptophan 5-hydroxylase (EC 1.14.16.4). These enzymes primarily hydroxylate phenylalanine, tyrosine, and tryptophan, respectively. These enzymes are all rate-limiting catalysts for important metabolic pathways. The proteins are structurally and functionally related, each containing iron, and catalysing ring hydroxylation of aromatic amino acids, using tetrahydrobiopterin (BH4) as a substrate. All are regulated by phosphorylation at serines in their N-termini. It has been suggested that the proteins each contain a conserved C-terminal catalytic (C) domain and an unrelated N-terminal regulatory (R) domain. It is possible that the R domains arose from genes that were recruited from different sources to combine with the common gene for the catalytic core. Thus, by combining with the same C domain, the proteins acquired the unique regulatory properties of the separate R domains.In humans, phenylalanine hydroxylase deficiency can cause of phenylketonuria, the most common inborn error of amino acid metabolism, Tryptophan hydroxylase catalyzes the rate-limiting step in serotonin biosynthesis: the conversion of tryptophan to 5-hydroxy-L-tryptophan and tyrosine hydroxylase catalyzes the rate limiting step in catecholamine biosynthesis: the conversion of tyrosine to L-DOPA.".
- Biopterin-dependent_aromatic_amino_acid_hydroxylase symbol "Biopterin_H".
- Biopterin-dependent_aromatic_amino_acid_hydroxylase thumbnail PDB_1mmt_EBI.jpg?width=300.
- Biopterin-dependent_aromatic_amino_acid_hydroxylase wikiPageID "32160985".
- Biopterin-dependent_aromatic_amino_acid_hydroxylase wikiPageLength "3361".
- Biopterin-dependent_aromatic_amino_acid_hydroxylase wikiPageOutDegree "38".
- Biopterin-dependent_aromatic_amino_acid_hydroxylase wikiPageRevisionID "684301906".
- Biopterin-dependent_aromatic_amino_acid_hydroxylase wikiPageWikiLink 5-Hydroxytryptophan.
- Biopterin-dependent_aromatic_amino_acid_hydroxylase wikiPageWikiLink Amino_acid.
- Biopterin-dependent_aromatic_amino_acid_hydroxylase wikiPageWikiLink Catalysis.
- Biopterin-dependent_aromatic_amino_acid_hydroxylase wikiPageWikiLink Catecholamine.
- Biopterin-dependent_aromatic_amino_acid_hydroxylase wikiPageWikiLink Category:Protein_domains.
- Biopterin-dependent_aromatic_amino_acid_hydroxylase wikiPageWikiLink Conserved_sequence.
- Biopterin-dependent_aromatic_amino_acid_hydroxylase wikiPageWikiLink Gene.
- Biopterin-dependent_aromatic_amino_acid_hydroxylase wikiPageWikiLink Hydroxylation.
- Biopterin-dependent_aromatic_amino_acid_hydroxylase wikiPageWikiLink L-DOPA.
- Biopterin-dependent_aromatic_amino_acid_hydroxylase wikiPageWikiLink Metabolism.
- Biopterin-dependent_aromatic_amino_acid_hydroxylase wikiPageWikiLink Phenylalanine.
- Biopterin-dependent_aromatic_amino_acid_hydroxylase wikiPageWikiLink Phenylalanine_hydroxylase.
- Biopterin-dependent_aromatic_amino_acid_hydroxylase wikiPageWikiLink Phenylketonuria.
- Biopterin-dependent_aromatic_amino_acid_hydroxylase wikiPageWikiLink Phosphorylation.
- Biopterin-dependent_aromatic_amino_acid_hydroxylase wikiPageWikiLink Protein.
- Biopterin-dependent_aromatic_amino_acid_hydroxylase wikiPageWikiLink Protein_domain.
- Biopterin-dependent_aromatic_amino_acid_hydroxylase wikiPageWikiLink Rate-determining_step.
- Biopterin-dependent_aromatic_amino_acid_hydroxylase wikiPageWikiLink Reaction_rate.
- Biopterin-dependent_aromatic_amino_acid_hydroxylase wikiPageWikiLink Regulation_of_gene_expression.
- Biopterin-dependent_aromatic_amino_acid_hydroxylase wikiPageWikiLink Serine.
- Biopterin-dependent_aromatic_amino_acid_hydroxylase wikiPageWikiLink Serotonin.
- Biopterin-dependent_aromatic_amino_acid_hydroxylase wikiPageWikiLink Structure.
- Biopterin-dependent_aromatic_amino_acid_hydroxylase wikiPageWikiLink Substrate_(chemistry).
- Biopterin-dependent_aromatic_amino_acid_hydroxylase wikiPageWikiLink Tetrahydrobiopterin.
- Biopterin-dependent_aromatic_amino_acid_hydroxylase wikiPageWikiLink Tryptophan.
- Biopterin-dependent_aromatic_amino_acid_hydroxylase wikiPageWikiLink Tryptophan_hydroxylase.
- Biopterin-dependent_aromatic_amino_acid_hydroxylase wikiPageWikiLink Tyrosine.
- Biopterin-dependent_aromatic_amino_acid_hydroxylase wikiPageWikiLink Tyrosine_hydroxylase.
- Biopterin-dependent_aromatic_amino_acid_hydroxylase wikiPageWikiLinkText "Biopterin-dependent aromatic amino acid hydroxylase".
- Biopterin-dependent_aromatic_amino_acid_hydroxylase wikiPageWikiLinkText "aromatic amino acid hydroxylases".
- Biopterin-dependent_aromatic_amino_acid_hydroxylase caption "crystal structure of ternary complex of the catalytic domain of human phenylalanine hydroxylase complexed with tetrahydrobiopterin and norleucine".
- Biopterin-dependent_aromatic_amino_acid_hydroxylase cdd "cd00361".
- Biopterin-dependent_aromatic_amino_acid_hydroxylase interpro "IPR019774".
- Biopterin-dependent_aromatic_amino_acid_hydroxylase name "Biopterin_H".
- Biopterin-dependent_aromatic_amino_acid_hydroxylase pfam "PF00351".
- Biopterin-dependent_aromatic_amino_acid_hydroxylase prosite "PDOC00316".
- Biopterin-dependent_aromatic_amino_acid_hydroxylase scop "1".
- Biopterin-dependent_aromatic_amino_acid_hydroxylase symbol "Biopterin_H".
- Biopterin-dependent_aromatic_amino_acid_hydroxylase wikiPageUsesTemplate Template:EC_number.
- Biopterin-dependent_aromatic_amino_acid_hydroxylase wikiPageUsesTemplate Template:Infobox_protein_family.
- Biopterin-dependent_aromatic_amino_acid_hydroxylase wikiPageUsesTemplate Template:InterPro_content.
- Biopterin-dependent_aromatic_amino_acid_hydroxylase wikiPageUsesTemplate Template:Phenylalanine_biosynthesis.
- Biopterin-dependent_aromatic_amino_acid_hydroxylase wikiPageUsesTemplate Template:Reflist.
- Biopterin-dependent_aromatic_amino_acid_hydroxylase subject Category:Protein_domains.
- Biopterin-dependent_aromatic_amino_acid_hydroxylase type Biomolecule.
- Biopterin-dependent_aromatic_amino_acid_hydroxylase type Protein.
- Biopterin-dependent_aromatic_amino_acid_hydroxylase type Chemical.
- Biopterin-dependent_aromatic_amino_acid_hydroxylase type Domain.
- Biopterin-dependent_aromatic_amino_acid_hydroxylase type Thing.
- Biopterin-dependent_aromatic_amino_acid_hydroxylase type Q206229.
- Biopterin-dependent_aromatic_amino_acid_hydroxylase type Q8054.
- Biopterin-dependent_aromatic_amino_acid_hydroxylase comment "In molecular biology, the biopterin-dependent aromatic amino acid hydroxylases (abbreviated AAAH) constitute a family of aromatic amino acid hydroxylases, including phenylalanine 4-hydroxylase (EC 1.14.16.1), tyrosine 3-hydroxylase (EC 1.14.16.2), and tryptophan 5-hydroxylase (EC 1.14.16.4). These enzymes primarily hydroxylate phenylalanine, tyrosine, and tryptophan, respectively. These enzymes are all rate-limiting catalysts for important metabolic pathways.".
- Biopterin-dependent_aromatic_amino_acid_hydroxylase label "Biopterin-dependent aromatic amino acid hydroxylase".
- Biopterin-dependent_aromatic_amino_acid_hydroxylase sameAs Q4915225.
- Biopterin-dependent_aromatic_amino_acid_hydroxylase sameAs m.0gwz3ml.
- Biopterin-dependent_aromatic_amino_acid_hydroxylase sameAs Q4915225.
- Biopterin-dependent_aromatic_amino_acid_hydroxylase wasDerivedFrom Biopterin-dependent_aromatic_amino_acid_hydroxylase?oldid=684301906.
- Biopterin-dependent_aromatic_amino_acid_hydroxylase depiction PDB_1mmt_EBI.jpg.
- Biopterin-dependent_aromatic_amino_acid_hydroxylase isPrimaryTopicOf Biopterin-dependent_aromatic_amino_acid_hydroxylase.
