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- Biological_functions_of_carbon_monoxide abstract "Carbon monoxide is produced naturally by the human body as a signaling molecule. Thus, carbon monoxide may have a physiological role in the body, such as a neurotransmitter or a blood vessel relaxant. Because of carbon monoxide's role in the body, abnormalities in its metabolism have been linked to a variety of diseases, including neurodegenerations, hypertension, heart failure, and inflammation.Functional Summary CO functions as an endogenous signaling molecule. CO modulates functions of the cardiovascular system. CO inhibits blood platelet aggregation and adhesion. CO may play a role as potential therapeutic agent.In mammals, carbon monoxide is naturally produced by the action of heme oxygenase 1 and 2 on the heme from hemoglobin breakdown. This process produces a certain amount of carboxyhemoglobin in normal persons, even if they do not breathe any carbon monoxide.Following the first report that carbon monoxide is a normal neurotransmitter in 1993, as well as one of three gases that naturally modulate inflammatory responses in the body (the other two being nitric oxide and hydrogen sulfide), carbon monoxide has received a great deal of clinical attention as a biological regulator. In many tissues, all three gases are known to act as anti-inflammatories, vasodilators, and encouragers of neovascular growth. However, the issues are complex, as neovascular growth is not always beneficial, since it plays a role in tumor growth, and also the damage from wet macular degeneration, a disease for which smoking (a major source of carbon monoxide in the blood, several times more than natural production) increases the risk from 4 to 6 times.There is a theory that, in some nerve cell synapses, when long-term memories are being laid down, the receiving cell makes carbon monoxide, which back-transmits to the transmitting cell, telling it to transmit more readily in future. Some such nerve cells have been shown to contain guanylate cyclase, an enzyme that is activated by carbon monoxide.Studies involving carbon monoxide have been conducted in many laboratories throughout the world for its anti-inflammatory and cytoprotective properties. These properties have potential to be used to prevent the development of a series of pathological conditions including ischemia reperfusion injury, transplant rejection, atherosclerosis, severe sepsis, severe malaria, or autoimmunity. Clinical tests involving humans have been performed, however the results have not yet been released.".
- Biological_functions_of_carbon_monoxide wikiPageID "45637911".
- Biological_functions_of_carbon_monoxide wikiPageLength "4890".
- Biological_functions_of_carbon_monoxide wikiPageOutDegree "17".
- Biological_functions_of_carbon_monoxide wikiPageRevisionID "651073283".
- Biological_functions_of_carbon_monoxide wikiPageWikiLink Anti-inflammatory.
- Biological_functions_of_carbon_monoxide wikiPageWikiLink Category:Gaseous_signaling_molecules.
- Biological_functions_of_carbon_monoxide wikiPageWikiLink Cell_signaling.
- Biological_functions_of_carbon_monoxide wikiPageWikiLink Enzyme.
- Biological_functions_of_carbon_monoxide wikiPageWikiLink Guanylyl_cyclase.
- Biological_functions_of_carbon_monoxide wikiPageWikiLink Heme.
- Biological_functions_of_carbon_monoxide wikiPageWikiLink Heme_oxygenase.
- Biological_functions_of_carbon_monoxide wikiPageWikiLink Hemoglobin.
- Biological_functions_of_carbon_monoxide wikiPageWikiLink Hydrogen_sulfide.
- Biological_functions_of_carbon_monoxide wikiPageWikiLink Long-term_memory.
- Biological_functions_of_carbon_monoxide wikiPageWikiLink Macular_degeneration.
- Biological_functions_of_carbon_monoxide wikiPageWikiLink Neovascularization.
- Biological_functions_of_carbon_monoxide wikiPageWikiLink Neurotransmitter.
- Biological_functions_of_carbon_monoxide wikiPageWikiLink Nitric_oxide.
- Biological_functions_of_carbon_monoxide wikiPageWikiLink Synapse.
- Biological_functions_of_carbon_monoxide wikiPageWikiLink Vasodilation.
- Biological_functions_of_carbon_monoxide wikiPageUsesTemplate Template:Reflist.
- Biological_functions_of_carbon_monoxide subject Category:Gaseous_signaling_molecules.
- Biological_functions_of_carbon_monoxide comment "Carbon monoxide is produced naturally by the human body as a signaling molecule. Thus, carbon monoxide may have a physiological role in the body, such as a neurotransmitter or a blood vessel relaxant. Because of carbon monoxide's role in the body, abnormalities in its metabolism have been linked to a variety of diseases, including neurodegenerations, hypertension, heart failure, and inflammation.Functional Summary CO functions as an endogenous signaling molecule.".
- Biological_functions_of_carbon_monoxide label "Biological functions of carbon monoxide".
- Biological_functions_of_carbon_monoxide sameAs Q19546691.
- Biological_functions_of_carbon_monoxide sameAs m.012zwbq5.
- Biological_functions_of_carbon_monoxide sameAs Биологическая_роль_эндогенного_моноксида_углерода.
- Biological_functions_of_carbon_monoxide sameAs Q19546691.
- Biological_functions_of_carbon_monoxide wasDerivedFrom Biological_functions_of_carbon_monoxide?oldid=651073283.
- Biological_functions_of_carbon_monoxide isPrimaryTopicOf Biological_functions_of_carbon_monoxide.