Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Biochemistry_of_Alzheimers_disease> ?p ?o }
- Biochemistry_of_Alzheimers_disease abstract "The biochemistry of Alzheimer's disease (AD), one of the most common causes of adult dementia, is as yet not well understood. AD has been identified as a protein misfolding disease due to the accumulation of abnormally folded amyloid beta protein in the brains of Alzheimer's patients. Amyloid beta, also written Aβ, is a short peptide that is an abnormal proteolytic byproduct of the transmembrane protein amyloid precursor protein (APP), whose function is unclear but thought to be involved in neuronal development. The presenilins are components of proteolytic complex involved in APP processing and degradation.Amyloid beta monomers are soluble and contain short regions of beta sheet and polyproline II helix secondary structures in solution, though they are largely alpha helical in membranes; however, at sufficiently high concentration, they undergo a dramatic conformational change to form a beta sheet-rich tertiary structure that aggregates to form amyloid fibrils. These fibrils deposit outside neurons in dense formations known as senile plaques or neuritic plaques, in less dense aggregates as diffuse plaques, and sometimes in the walls of small blood vessels in the brain in a process called amyloid angiopathy or congophilic angiopathy.AD is also considered a tauopathy due to abnormal aggregation of the tau protein, a microtubule-associated protein expressed in neurons that normally acts to stabilize microtubules in the cell cytoskeleton. Like most microtubule-associated proteins, tau is normally regulated by phosphorylation; however, in AD patients, hyperphosphorylated tau accumulates as paired helical filaments that in turn aggregate into masses inside nerve cell bodies known as neurofibrillary tangles and as dystrophic neurites associated with amyloid plaques. Although little is known about the process of filament assembly, it has recently been shown that a depletion of a prolyl isomerase protein in the parvulin family accelerates the accumulation of abnormal tau.Neuroinflammation is also involved in the complex cascade leading to AD pathology and symptoms. Considerable pathological and clinical evidence documents immunological changes associated with AD, including increased pro-inflammatory cytokine concentrations in the blood and cerebrospinal fluid. Whether these changes may be a cause or consequence of AD remains to be fully understood, but inflammation within the brain, including increased reactivity of the resident microglia towards amyloid deposits, has been implicated in the pathogenesis and progression of AD.".
- Biochemistry_of_Alzheimers_disease thumbnail Blausen_0017_AlzheimersDisease.png?width=300.
- Biochemistry_of_Alzheimers_disease wikiPageID "7201415".
- Biochemistry_of_Alzheimers_disease wikiPageLength "33564".
- Biochemistry_of_Alzheimers_disease wikiPageOutDegree "119".
- Biochemistry_of_Alzheimers_disease wikiPageRevisionID "704067363".
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Acetylcholine.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Acetylcholinesterase.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Adenosine_triphosphate.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Alpha_helix.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Alzheimers_disease.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Amyloid.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Amyloid_beta.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Amyloid_precursor_protein.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Antioxidant.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Apolipoprotein_E.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Apoptosis.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Atrophy.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Axon.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Beta_sheet.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Biomarker.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Biomolecular_structure.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Carbohydrate_metabolism.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Casein_kinase_2.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Category:Alzheimers_disease.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Category:Neurology.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Category:Pathology.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Category:Unsolved_problems_in_neuroscience.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Cell_(biology).
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Cerebral_amyloid_angiopathy.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Cerebral_cortex.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Cholesterol.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Cholinergic.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Chromosome_21_(human).
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Cingulate_cortex.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Coenzyme_Q10.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Cognition.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Conformational_change.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Cytoskeleton.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Dementia.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Dendrite.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Dolichol.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Down_syndrome.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Frontal_lobe.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Gene_dosage.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Glutamic_acid.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Glycosylation.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Human_brain.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Lead_compound.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Lipid_peroxidation.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Macroscopic_scale.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Memory.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Microglia.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Microscopy.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Microtubule.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Microtubule-associated_protein.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Monomer.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Neurite.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Neurofibrillary_tangle.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Neuron.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Neurotransmission.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Neurotransmitter.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Norepinephrine.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Oligomer.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Oxidative_stress.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Parietal_lobe.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Parvulin.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Peptide.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Phosphorylation.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Polyprenol.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Polyproline_helix.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Presenilin.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Progeroid_syndromes.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Prolyl_isomerase.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Protein.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Protein_folding.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Proteolysis.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Proteopathy.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Senile_plaques.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Serotonin.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Solagran.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Solubility.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Somatostatin.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Swinburne_University_of_Technology.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Synapse.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Tau_protein.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Tauopathy.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Temporal_lobe.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Terpenoid.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink Transmembrane_protein.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLink File:Blausen_0017_AlzheimersDisease.png.
- Biochemistry_of_Alzheimers_disease wikiPageWikiLinkText "Biochemistry of Alzheimer's disease".
- Biochemistry_of_Alzheimers_disease wikiPageWikiLinkText "amyloid hypothesis".
- Biochemistry_of_Alzheimers_disease wikiPageWikiLinkText "dystrophic neuritis".
- Biochemistry_of_Alzheimers_disease wikiPageWikiLinkText "hypothesized".
- Biochemistry_of_Alzheimers_disease wikiPageUsesTemplate Template:Reflist.
- Biochemistry_of_Alzheimers_disease subject Category:Alzheimers_disease.
- Biochemistry_of_Alzheimers_disease subject Category:Neurology.
- Biochemistry_of_Alzheimers_disease subject Category:Pathology.
- Biochemistry_of_Alzheimers_disease subject Category:Unsolved_problems_in_neuroscience.