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- Biobreeding_rat abstract "Biobreeding rat also known as the BB or BBDP rat is an inbred laboratory rat strain that spontaneously develops autoimmune Type 1 Diabetes. Like the NOD mice, BB rats are used as an animal model for Type 1 diabetes. The strain re-capitulates many of the features of human type 1 diabetes, and has contributed greatly to the research of T1D pathogenesis.Two T1D susceptibility genes have been identified in the BB rat. The susceptible MHC class II RT1u haplotype on chromosome 20 and a null mutation in the GIMAP5 gene on chromosome 4. The Gimap5 mutation results in severe T cell lymphopenia in the BB rat and is thought to contribute to T1D pathogenesis through impaired development and function and regulatory T cells. Recently, 8 additional loci on rat chromosomes 1,2,3,6 (2 loci), 12 and 14 have been shown to be linked to Type 1 Diabetes in the BB rat.".
- Biobreeding_rat wikiPageID "12379787".
- Biobreeding_rat wikiPageLength "3087".
- Biobreeding_rat wikiPageOutDegree "16".
- Biobreeding_rat wikiPageRevisionID "665089500".
- Biobreeding_rat wikiPageWikiLink Autoimmunity.
- Biobreeding_rat wikiPageWikiLink Category:Laboratory_rat_strains.
- Biobreeding_rat wikiPageWikiLink Diabetes_mellitus_type_1.
- Biobreeding_rat wikiPageWikiLink GIMAP5.
- Biobreeding_rat wikiPageWikiLink Hyperglycemia.
- Biobreeding_rat wikiPageWikiLink Ketoacidosis.
- Biobreeding_rat wikiPageWikiLink Laboratory_rat.
- Biobreeding_rat wikiPageWikiLink Model_organism.
- Biobreeding_rat wikiPageWikiLink NOD_mice.
- Biobreeding_rat wikiPageWikiLink Rat.
- Biobreeding_rat wikiPageWikiLink Worcester,_Massachusetts.
- Biobreeding_rat wikiPageWikiLinkText "Biobreeding rat".
- Biobreeding_rat wikiPageWikiLinkText "biobreeding rat".
- Biobreeding_rat wikiPageUsesTemplate Template:Reflist.
- Biobreeding_rat subject Category:Laboratory_rat_strains.
- Biobreeding_rat hypernym Strain.
- Biobreeding_rat type Species.
- Biobreeding_rat type Right.
- Biobreeding_rat comment "Biobreeding rat also known as the BB or BBDP rat is an inbred laboratory rat strain that spontaneously develops autoimmune Type 1 Diabetes. Like the NOD mice, BB rats are used as an animal model for Type 1 diabetes. The strain re-capitulates many of the features of human type 1 diabetes, and has contributed greatly to the research of T1D pathogenesis.Two T1D susceptibility genes have been identified in the BB rat.".
- Biobreeding_rat label "Biobreeding rat".
- Biobreeding_rat sameAs Q795497.
- Biobreeding_rat sameAs BB-Ratte.
- Biobreeding_rat sameAs m.02w1_hy.
- Biobreeding_rat sameAs Q795497.
- Biobreeding_rat wasDerivedFrom Biobreeding_rat?oldid=665089500.
- Biobreeding_rat isPrimaryTopicOf Biobreeding_rat.