Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Bifeprunox> ?p ?o }
Showing triples 1 to 88 of
88
with 100 triples per page.
- Bifeprunox abstract "Bifeprunox (INN) (code name DU-127,090) is an atypical antipsychotic which, similarly to aripiprazole, combines minimal D2 receptor agonism with serotonin receptor agonism. It was under development for the treatment of schizophrenia but has since been abandoned.Bifeprunox has a novel mechanism of action. Conventional antipsychotics are classed into typical and atypical. The typical antipsychotics, such as chlorpromazine and haloperidol, are potent D2 receptor antagonists. The atypical antipsychotics started with clozapine, these are classified as multireceptor interacting compounds, acting as an agonist towards 5-HT1A and an antagonist towards D2 receptors among other 5-HT and DA receptors. Bifeprunox and other novel atypical antipsychotics will instead of antagonizing D2 receptors, will act as partial agonists, as well as partial agonists towards 5-HT1A receptors.In a multi-center, placebo-controlled study, 20 mg of bifeprunox was found to be significantly more effective than placebo at reducing symptoms of schizophrenia, with a low incidence of side effects.An NDA for Bifeprunox was filed with the U.S. Food and Drug Administration in January 2007. The FDA rejected the application in August 2007. In June 2009, Solvay and Lundbeck decided to cease development because \"efficacy data did not support pursuing the existing development strategy of stabilisation of non-acute patients with schizophrenia.\"".
- Bifeprunox atcPrefix "none".
- Bifeprunox casNumber "350992-10-8".
- Bifeprunox fdaUniiCode "AP69E83Z79".
- Bifeprunox iupacName "7-[4-(biphenyl-3-ylmethyl)piperazin-1-yl]-1,3-benzoxazol-2(3H)-one".
- Bifeprunox pubchem "208951".
- Bifeprunox thumbnail Bifeprunox.png?width=300.
- Bifeprunox wikiPageID "11881741".
- Bifeprunox wikiPageLength "5532".
- Bifeprunox wikiPageOutDegree "22".
- Bifeprunox wikiPageRevisionID "668899150".
- Bifeprunox wikiPageWikiLink 5-HT_receptor.
- Bifeprunox wikiPageWikiLink Agonist.
- Bifeprunox wikiPageWikiLink Aripiprazole.
- Bifeprunox wikiPageWikiLink Atypical_antipsychotic.
- Bifeprunox wikiPageWikiLink Category:Atypical_antipsychotics.
- Bifeprunox wikiPageWikiLink Category:Benzoxazoles.
- Bifeprunox wikiPageWikiLink Category:Carbamates.
- Bifeprunox wikiPageWikiLink Category:Piperazines.
- Bifeprunox wikiPageWikiLink Chlorpromazine.
- Bifeprunox wikiPageWikiLink Clozapine.
- Bifeprunox wikiPageWikiLink Dopamine_receptor_D2.
- Bifeprunox wikiPageWikiLink Food_and_Drug_Administration.
- Bifeprunox wikiPageWikiLink Haloperidol.
- Bifeprunox wikiPageWikiLink International_nonproprietary_name.
- Bifeprunox wikiPageWikiLink Pardoprunox.
- Bifeprunox wikiPageWikiLink Partial_agonist.
- Bifeprunox wikiPageWikiLink Receptor_antagonist.
- Bifeprunox wikiPageWikiLink Schizophrenia.
- Bifeprunox wikiPageWikiLink Typical_antipsychotic.
- Bifeprunox wikiPageWikiLink File:Bifeprunox_synth.png.
- Bifeprunox wikiPageWikiLinkText "Bifeprunox".
- Bifeprunox wikiPageWikiLinkText "bifeprunox".
- Bifeprunox atcPrefix "none".
- Bifeprunox c "24".
- Bifeprunox casNumber "350992".
- Bifeprunox chembl "218166".
- Bifeprunox chemspiderid "181044".
- Bifeprunox h "23".
- Bifeprunox inchi "1".
- Bifeprunox inchikey "CYGODHVAJQTCBG-UHFFFAOYAL".
- Bifeprunox iupacName "7".
- Bifeprunox molecularWeight "385.458".
- Bifeprunox n "3".
- Bifeprunox o "2".
- Bifeprunox pubchem "208951".
- Bifeprunox smiles "O=C2Oc1cN5CCNCC5".
- Bifeprunox stdinchi "1".
- Bifeprunox stdinchikey "CYGODHVAJQTCBG-UHFFFAOYSA-N".
- Bifeprunox unii "AP69E83Z79".
- Bifeprunox verifiedfields "changed".
- Bifeprunox verifiedrevid "459978705".
- Bifeprunox wikiPageUsesTemplate Template:Antipsychotics.
- Bifeprunox wikiPageUsesTemplate Template:Cascite.
- Bifeprunox wikiPageUsesTemplate Template:Chemspidercite.
- Bifeprunox wikiPageUsesTemplate Template:Dopaminergics.
- Bifeprunox wikiPageUsesTemplate Template:Drugbox.
- Bifeprunox wikiPageUsesTemplate Template:Ebicite.
- Bifeprunox wikiPageUsesTemplate Template:Fdacite.
- Bifeprunox wikiPageUsesTemplate Template:Piperazines.
- Bifeprunox wikiPageUsesTemplate Template:Reflist.
- Bifeprunox wikiPageUsesTemplate Template:Serotonergics.
- Bifeprunox wikiPageUsesTemplate Template:Stdinchicite.
- Bifeprunox subject Category:Atypical_antipsychotics.
- Bifeprunox subject Category:Benzoxazoles.
- Bifeprunox subject Category:Carbamates.
- Bifeprunox subject Category:Piperazines.
- Bifeprunox type ChemicalSubstance.
- Bifeprunox type Drug.
- Bifeprunox type Amide.
- Bifeprunox type Antagonist.
- Bifeprunox type Carbamate.
- Bifeprunox type Drug.
- Bifeprunox type Ester.
- Bifeprunox type Heterocycle.
- Bifeprunox type ChemicalObject.
- Bifeprunox type Thing.
- Bifeprunox type Q8386.
- Bifeprunox comment "Bifeprunox (INN) (code name DU-127,090) is an atypical antipsychotic which, similarly to aripiprazole, combines minimal D2 receptor agonism with serotonin receptor agonism. It was under development for the treatment of schizophrenia but has since been abandoned.Bifeprunox has a novel mechanism of action. Conventional antipsychotics are classed into typical and atypical. The typical antipsychotics, such as chlorpromazine and haloperidol, are potent D2 receptor antagonists.".
- Bifeprunox label "Bifeprunox".
- Bifeprunox sameAs Q4904729.
- Bifeprunox sameAs m.02rwmqh.
- Bifeprunox sameAs Bifeprunoks.
- Bifeprunox sameAs Bifeprunoks.
- Bifeprunox sameAs Q4904729.
- Bifeprunox wasDerivedFrom Bifeprunox?oldid=668899150.
- Bifeprunox depiction Bifeprunox.png.
- Bifeprunox isPrimaryTopicOf Bifeprunox.