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- Bicifadine abstract "Bicifadine (DOV-220,075) is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) discovered at American Cyanamid as an analgesic drug candidate, and licensed to DOV Pharmaceutical in 1998 after American Cyanamid was acquired by Wyeth.In January 2007, Dov licensed the rights to bicifadine to XTL Biopharmaceuticals after bicifadine failed in a Phase III clinical trial for chronic lower back pain. XTL ran a PhaseIIb clinical trial for pain caused by diabetic neuropathy, which failed in 2008; XTL terminated the agreement in 2010. In 2010 Dov was acquired by Euthymics Bioscience which intended to continue development of other candidates from Dov's portfolio.Bicifadine has a non-opioid, non-NSAID mechanism for the treatment of pain, which should have less abuse potential than opioid drugs and less propensity to cause gastric ulcers than NSAID drugs. While the drug is purported to be a serotonin (SERT) and noradrenaline transporter (NET) inhibitor, it also has effects at the dopamine transporter (DAT), effectively making it a broad-spectrum monoamine transporter inhibitor or \"triple reuptake inhibitor.\"".
- Bicifadine atcPrefix "none".
- Bicifadine casNumber "71195-57-8".
- Bicifadine fdaUniiCode "B0SV3N7J3H".
- Bicifadine iupacName "1-(4-Methylphenyl)-3-azabicyclo[3.1.0]hexane".
- Bicifadine pubchem "47953".
- Bicifadine thumbnail Bicifadine.svg?width=300.
- Bicifadine wikiPageExternalLink drawFiling.asp?docKey=137-000114420413017126-72672IPVQ4UFBUKR6AA4FI0HPE&docFormat=HTM&formType=6-K.
- Bicifadine wikiPageID "14724536".
- Bicifadine wikiPageLength "5992".
- Bicifadine wikiPageOutDegree "19".
- Bicifadine wikiPageRevisionID "693769309".
- Bicifadine wikiPageWikiLink American_Cyanamid.
- Bicifadine wikiPageWikiLink Analgesic.
- Bicifadine wikiPageWikiLink Category:Abandoned_drugs.
- Bicifadine wikiPageWikiLink Category:Analgesics.
- Bicifadine wikiPageWikiLink Category:Cyclopropanes.
- Bicifadine wikiPageWikiLink Category:Imides.
- Bicifadine wikiPageWikiLink Category:Serotonin-norepinephrine_reuptake_inhibitors.
- Bicifadine wikiPageWikiLink DOV-216,303.
- Bicifadine wikiPageWikiLink DOV_Pharmaceutical.
- Bicifadine wikiPageWikiLink Diabetic_neuropathy.
- Bicifadine wikiPageWikiLink Dopamine_transporter.
- Bicifadine wikiPageWikiLink Mechanism_of_action.
- Bicifadine wikiPageWikiLink Nonsteroidal_anti-inflammatory_drug.
- Bicifadine wikiPageWikiLink Norepinephrine_transporter.
- Bicifadine wikiPageWikiLink Opioid.
- Bicifadine wikiPageWikiLink Serotonin_transporter.
- Bicifadine wikiPageWikiLink Serotonin–norepinephrine–dopamine_reuptake_inhibitor.
- Bicifadine wikiPageWikiLink Wyeth.
- Bicifadine wikiPageWikiLinkText "Bicifadine".
- Bicifadine wikiPageWikiLinkText "bicifadine".
- Bicifadine atcPrefix "none".
- Bicifadine c "12".
- Bicifadine casNumber "71195".
- Bicifadine chembl "511099".
- Bicifadine chemspiderid "9889978".
- Bicifadine eliminationHalfLife "5760.0".
- Bicifadine excretion "renal".
- Bicifadine h "15".
- Bicifadine inchi "1".
- Bicifadine inchikey "OFYVIGTWSQPCLF-NWDGAFQWBL".
- Bicifadine iupacName "1".
- Bicifadine legalUs "Unscheduled".
- Bicifadine molecularWeight "173.25".
- Bicifadine n "1".
- Bicifadine pubchem "47953".
- Bicifadine routesOfAdministration "Oral".
- Bicifadine smiles "c1cc[C@]32CNC[C@@H]2C3".
- Bicifadine stdinchi "1".
- Bicifadine stdinchikey "OFYVIGTWSQPCLF-NWDGAFQWSA-N".
- Bicifadine unii "B0SV3N7J3H".
- Bicifadine verifiedfields "changed".
- Bicifadine verifiedrevid "462798006".
- Bicifadine watchedfields "changed".
- Bicifadine width "170".
- Bicifadine wikiPageUsesTemplate Template:Adrenergics.
- Bicifadine wikiPageUsesTemplate Template:Analgesics.
- Bicifadine wikiPageUsesTemplate Template:Antidepressants.
- Bicifadine wikiPageUsesTemplate Template:Cascite.
- Bicifadine wikiPageUsesTemplate Template:Chemspidercite.
- Bicifadine wikiPageUsesTemplate Template:Dopaminergics.
- Bicifadine wikiPageUsesTemplate Template:Drugbox.
- Bicifadine wikiPageUsesTemplate Template:Ebicite.
- Bicifadine wikiPageUsesTemplate Template:Fdacite.
- Bicifadine wikiPageUsesTemplate Template:Reflist.
- Bicifadine wikiPageUsesTemplate Template:Serotonergics.
- Bicifadine wikiPageUsesTemplate Template:Stdinchicite.
- Bicifadine subject Category:Abandoned_drugs.
- Bicifadine subject Category:Analgesics.
- Bicifadine subject Category:Cyclopropanes.
- Bicifadine subject Category:Imides.
- Bicifadine subject Category:Serotonin-norepinephrine_reuptake_inhibitors.
- Bicifadine hypernym Inhibitor.
- Bicifadine type ChemicalSubstance.
- Bicifadine type Drug.
- Bicifadine type Analgesic.
- Bicifadine type Antidepressant.
- Bicifadine type Drug.
- Bicifadine type Heterocycle.
- Bicifadine type Inhibitor.
- Bicifadine type Page.
- Bicifadine type ChemicalObject.
- Bicifadine type Thing.
- Bicifadine type Q8386.
- Bicifadine comment "Bicifadine (DOV-220,075) is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) discovered at American Cyanamid as an analgesic drug candidate, and licensed to DOV Pharmaceutical in 1998 after American Cyanamid was acquired by Wyeth.In January 2007, Dov licensed the rights to bicifadine to XTL Biopharmaceuticals after bicifadine failed in a Phase III clinical trial for chronic lower back pain.".
- Bicifadine label "Bicifadine".
- Bicifadine sameAs Q4903628.
- Bicifadine sameAs m.03gvmsh.
- Bicifadine sameAs Bicifadin.
- Bicifadine sameAs Bicifadin.
- Bicifadine sameAs Q4903628.
- Bicifadine wasDerivedFrom Bicifadine?oldid=693769309.
- Bicifadine depiction Bicifadine.svg.
- Bicifadine isPrimaryTopicOf Bicifadine.